scholarly journals Effect of Active and Passive Smoking on Retinal Nerve Fibre Layer and Ganglion Cell Complex

2017 ◽  
Vol 2017 ◽  
pp. 1-6 ◽  
Author(s):  
Amany Abd El-Fattah El-Shazly ◽  
Yousra Ahmed Thabet Farweez ◽  
Lamia Salah Elewa ◽  
Yasser Abdelmageuid Elzankalony ◽  
Botheina Ahmed Thabet Farweez
Keyword(s):  
Ganglion Cell ◽  
Nerve Fibre ◽  
Retinal Nerve Fibre Layer ◽  
Cell Complex ◽  
Ganglion Cell Complex ◽  
Urinary Cotinine ◽  
Fibre Layer ◽  
Significant Difference ◽  
Nerve Fibre Layer ◽  
Sd Oct

Aim.To evaluate the possible structural and functional changes in the retinal nerve fibre layer (RNFL) and the ganglion cell complex (GCC) of chronic smokers and compare them with those of passive healthy smokers using spectral domain optical coherence tomography (SD-OCT) and pattern electroretinogram (PERG).Materials and Methods. We include 80 active chronic smokers and 80 age- and sex-matched healthy passive smokers. After a full ophthalmological examination, SD-OCT and PERG were tested for all participants. Urinary levels of cotinine and creatinine with subsequent calculation of the cotinine creatinine ratio (CCR).Results. Inferior and superior quadrants of RNFL were thinner in group I, but nasal and temporal quadrants did not show significant difference between the groups. There were no significant differences of GCC values between the two groups. There was no significant difference of PERG-P50 amplitude and latency; however, PERG-N95 showed significant difference between the two groups. Multiple regression analyses demonstrated that the number of cigarettes/day, urinary cotinine, and PERG-N95 amplitude are the most important determinants for both superior and inferior RNFL thicknesses.Conclusion. RNFL thickness decreases in chronic, healthy, heavy cigarette smokers, and this thinning is related to the number of cigarettes/day, urinary cotinine, and PERG-N95 latency and amplitude.

scholarly journals Retinal nerve fibre layer and ganglion cell complex thickness in patients with keratoconus

2018 ◽  
Vol 77 (1) ◽  
Author(s):  
Prianka Cuppusamy ◽  
Nokwanda Makhanya ◽  
Mbekezeli Methula ◽  
Kausar M. Essop ◽  
Duduzile Sibisi ◽  
...  
Keyword(s):  
Ganglion Cell ◽  
Nerve Fibre ◽  
Retinal Nerve Fibre Layer ◽  
Cell Complex ◽  
Control Group ◽  
Ganglion Cell Complex ◽  
Equal Distribution ◽  
Fibre Layer ◽  
The Mean ◽  
Nerve Fibre Layer

Background: Keratoconus, a corneal ectasia, is associated with corneal thinning and altered optical media. Consequently, assessment of the visual field, optic nerve head and intraocular pressure measurements may be challenging in patients with keratoconus. Few studies have investigated posterior segment variables including the retinal nerve fibre layer (RNFL) and ganglion cell complex (GCC) thickness in patients with keratoconus.Aim: To investigate RNFL and GCC thickness in patients with keratoconus.Methods: A comparative quantitative research design was used. The sample consisted of 56 participants (28 with mild, moderate or severe keratoconus, and 28 controls) who accessed the optometry clinic at the University of KwaZulu-Natal. There was an equal distribution of male (n = 14) and female (n = 14) participants in the keratoconus and control groups. Most participants were black (n = 34) or Indian (n = 18). Corneal power and refractive error were assessed with the Oculus Keratograph and subjective refraction respectively. The iVue-100 optical coherence topography device was used to measure RNFL and GCC thickness. Data were analysed by descriptive and inferential statistics.Results: The mean global RNFL thickness was slightly higher in the control group than the keratoconus group for the right (106 µm vs. 99 µm) and left (103 µm vs. 98 µm) eyes but these differences were not significant (p ≥ 0.057). For all RNFL quadrants, slightly lower mean RNFL measurements were found in the keratoconus group. The mean GCC thicknesses were marginally higher (3 µm – 6 µm) in the control group.Conclusion: The RNFL and GCC thickness differences between patients with keratoconus and controls are not clinically significant. Therefore, abnormally reduced RNFL and GCC thickness measurements in patients with keratoconus warrant further investigation for other pathologies specifically glaucoma.

Comparison of retinal ganglion cell-related layer asymmetry between early glaucoma eyes with superior and inferior hemiretina damage

2019 ◽  
Vol 104 (5) ◽  
pp. 655-659 ◽  
Author(s):  
Hitomi Saito ◽  
Aiko Iwase ◽  
Makoto Araie
Keyword(s):  
Ganglion Cell ◽  
Layer Thickness ◽  
Nerve Fibre ◽  
Retinal Ganglion Cell ◽  
Retinal Nerve Fibre Layer ◽  
Retinal Ganglion ◽  
Fibre Layer ◽  
Significant Difference ◽  
Nerve Fibre Layer ◽  
Normal Controls

AimTo compare retinal ganglion cell (RGC)-related layer thickness asymmetry between early open-angle glaucoma (EG) eyes with superior and inferior hemiretina damage.MethodsThis was a retrospective study including 95 EG eyes (mean deviation >−2 dB, including 43 preperimetric glaucoma eyes) with photographically determined glaucomatous retinal nerve fibre layer defect and disc change confined to one hemiretina, and 93 age, sex and refraction matched normal subjects as controls. Ganglion cell complex, ganglion cell layer+inner plexiform layer and circumpapillary retinal nerve fibre layer thickness measured by spectral domain optical coherence imaging were compared between the affected and unaffected hemiretinae within each glaucoma eye as well as to those of the corresponding hemiretina of normal control eyes.ResultsIntraeye comparison revealed that there was no significant difference in all parameters between the affected and unaffected hemiretinae in eyes with superior hemiretina damage (p=0.110~0.343) while all parameters were thinner in the affected inferior hemiretina compared with the unaffected superior hemiretina in eyes with inferior hemiretina damage (p<0.001). The affected hemiretina of both groups were thinner compared with normal controls (p<0.001). All parameters of the unaffected hemiretina of eyes with superior hemiretina damage were thinner than normal controls (p<0.001), while eyes with inferior hemiretina damage showed no significant difference compared with those of their corresponding hemiretina of normal eyes (p=0.086~0.924).ConclusionThe pattern of RGC damage in early stage glaucoma may differ depending on which horizontal hemiretina is affected first.

SD-OCT peripapillary nerve fibre layer and ganglion cell complex parameters in glaucoma: principal component analysis

2020 ◽  
pp. bjophthalmol-2020-316296
Author(s):  
Marta Pazos ◽  
Marc Biarnés ◽  
Andrés Blasco-Alberto ◽  
Agnieszka Dyrda ◽  
Miguel Ángel Luque-Fernández ◽  
...  
Keyword(s):  
Principal Component Analysis ◽  
Ganglion Cell ◽  
Nerve Fibre ◽  
Principal Component ◽  
Component Analysis ◽  
Cell Complex ◽  
Ganglion Cell Complex ◽  
Discriminative Ability ◽  
Nerve Fibre Layer ◽  
Sd Oct

Background/aimsTo identify objective glaucoma-related structural features based on peripapillary (p) and macular (m) spectral domain optical coherence tomography (SD-OCT) parameters and assess their discriminative ability between healthy and glaucoma patients.MethodsTwo hundred and sixty eyes (91 controls and 169 glaucoma) were included in this prospective study. After a complete examination, all participants underwent the posterior pole and the peripapillary retinal nerve fibre layer (pRNFL) protocols of the Spectralis SD-OCT. Principal component analysis (PCA), a data reduction method, was applied to identify and characterise the main information provided by the ganglion cell complex (GCC). The discriminative ability between healthy and glaucomatous eyes of the first principal components (PCs) was compared with that of conventional SD-OCT parameters (pRNFL, macular RNFL (mRNFL), macular ganglion cell layer (mGCL)and macular inner plexiform layer (mIPL)) using 10-fold cross-validated areas under the curve (AUC).ResultsThe first PC explained 58% of the total information contained in the GCC and the pRNFL parameters and was the result of a general combination of almost all variables studied (diffuse distribution). Other PCs were driven mainly by pRNFL and mRNFL measurements. PCs and pRNFL had similar AUC (0.95 vs 0.96, p=0.88), and outperformed the other structural measurements: mRNFL (0.91, p=0.002), mGCL (0.92, p=0.02) and mIPL (0.92, p=0.0001).ConclusionsPCA identified a diffuse representation of the papillary and macular SD-OCT parameters as the most important PC to summarise structural data in healthy and glaucomatous eyes. PCs and pRNFL parameters showed the greatest discriminative ability between healthy and glaucoma cases.

scholarly journals Retinal nerve fibre layer, ganglion cell layer and choroid thinning in migraine with aura

2014 ◽  
Vol 14 (1) ◽  
Author(s):  
Metin Ekinci ◽  
Erdinç Ceylan ◽  
Halil Hüseyin Çağatay ◽  
Sadullah Keleş ◽  
Nergiz Hüseyinoğlu ◽  
...  
Keyword(s):  
Ganglion Cell ◽  
Nerve Fibre ◽  
Migraine With Aura ◽  
Ganglion Cell Layer ◽  
Cell Layer ◽  
Retinal Nerve Fibre Layer ◽  
Fibre Layer ◽  
Nerve Fibre Layer

scholarly journals Comparison of a commercial spectral-domain OCT and swept-source OCT based on an angiography scan for measuring circumpapillary retinal nerve fibre layer thickness

2019 ◽  
Vol 104 (7) ◽  
pp. 974-979 ◽  
Author(s):  
Bingyao Tan ◽  
Jacqueline Chua ◽  
Thiyagrajan Harish ◽  
Amanda Lau ◽  
Alfred Tau Liang Gan ◽  
...  
Keyword(s):  
Nerve Fibre ◽  
Excellent Agreement ◽  
Retinal Nerve Fibre Layer ◽  
Spectral Domain ◽  
Wide Field ◽  
Swept Source ◽  
Rnfl Thickness ◽  
Fibre Layer ◽  
Nerve Fibre Layer ◽  
Sd Oct

Background/aimsTo assess the agreement in measuring retinal nerve fibre layer (RNFL) thickness between spectral-domain (SD; Cirrus HD, Carl Zeiss Meditec, USA) optical coherence tomography (OCT) and swept-source (SS; Plex Elite 9000, Carl Zeiss Meditec) OCT using an OCT angiography (OCTA) scanning protocol.Methods57 participants (12 glaucomatous, 8 ocular hypertensive and 74 normal eyes) were scanned with two OCT instruments by a single experienced operator on the same day. Circumpapillary RNFL thicknesses were automatically segmented for SD-OCT and manually segmented for SS-OCTA scans. Agreement of global RNFL thickness, as well as average thickness in four quadrants was assessed using intraclass correlation coefficients (ICCs).ResultsThere was excellent agreement in the inferior and superior quadrants and the global (all ICC >0.90), followed by good agreement in the temporal (ICC=0.79) and nasal (ICC=0.73) quadrants. The ICC values were similar in the subgroups except within the ocular hypertension group, where the nasal quadrant was less agreeable (ICC=0.31). SS-OCTA-derived RNFL thickness was on average 3 µm thicker than SD-OCT, particularly in the nasal (69.7±11.5 µm vs 66.3±9.3 µm; p<0.001) and temporal (75.6±13.7 µm vs 67.9±12.3 µm; p<0.001) quadrants.ConclusionsRNFL measurements taken with SS-OCTA have good-to-excellent agreement with SD-OCT, which suggests that the RNFL thickness can be sufficiently extracted from wide-field OCTA scans.

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