Non-sedative antihistamines: ▾ terfenadine and ▾ astemizole

1984 ◽  
Vol 22 (6) ◽  
pp. 21-23
Keyword(s):  
Allergic Rhinitis ◽  
Histamine Release ◽  
Cns Effects

Terfenadine (Triludan - Merrell) and astemizole (Hismanal - Janssen) are two chemically unrelated oral H1-receptor antihistamines marketed recently for the relief of allergic rhinitis, conjunctivitis and other manifestations of histamine release, such as urticaria. Both are claimed to be free of the usual anticholinergic and CNS effects, especially sedation, which limit the use of other H1 antihistamines. If this major claim justified?

Substance P induced histamine release from nasal mucosa of subjects with and without allergic rhinitis

2000 ◽  
Vol 49 (10) ◽  
pp. 520-523 ◽  
Author(s):  
G. Hanf ◽  
K. Schierhorn ◽  
T. Brunnée ◽  
O. Noga ◽  
D. Verges ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Substance P ◽  
Histamine Release ◽  
Nasal Mucosa

Enhanced basophil histamine release to concanavalin A in allergic rhinitis

1986 ◽  
Vol 78 (1) ◽  
pp. 90-97 ◽  
Author(s):  
W BUSSE ◽  
C SWENSON ◽  
G SHARPE ◽  
M KOSCHAT
Keyword(s):  
Allergic Rhinitis ◽  
Histamine Release ◽  
Concanavalin A

Comparison of histamine assay methods in measuring in vitro-induced histamine release in patients with allergic rhinitis

Allergy ◽  
1989 ◽  
Vol 44 (3) ◽  
pp. 235-239 ◽  
Author(s):  
R. J. Harvima ◽  
I. T. Harvima ◽  
L. Tuomisto ◽  
M. Horsmanheimo ◽  
J. E. Fräki
Keyword(s):  
Allergic Rhinitis ◽  
Histamine Release ◽  
Assay Methods

scholarly journals Effectiveness of histamine release test in the diagnosis of allergic rhinitis

2015 ◽  
Vol 33 (4) ◽  
pp. 215-219
Author(s):  
Kazuya Kurakami ◽  
Nobuo Ohta ◽  
Yusuke Suzuki ◽  
Yuichi Takahashi ◽  
Atsushi Yuta ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Histamine Release ◽  
Release Test

Loratadine: A Potent, Nonsedating, and Long-Acting H1 Antagonist

1987 ◽  
Vol 1 (2) ◽  
pp. 95-99 ◽  
Author(s):  
Harold M. Friedman
Keyword(s):  
Clinical Trials ◽  
Allergic Rhinitis ◽  
Receptor Antagonist ◽  
Preclinical Studies ◽  
Duration Of Action ◽  
Once Daily ◽  
Long Acting ◽  
H1 Antagonist ◽  
Cns Effects

Loratadine, a nonclassical selective, peripheral H1-receptor antagonist has undergone extensive preclinical studies and clinical trials in over 6,000 patients. In the treatment of allergic rhinitis, loratadine has efficacy equivalent to clemastine, terfenadine, astemizole, and mequitazine. Its duration of action is 18–24 hours making once daily dosing practical. Loratadine is virtually devoid of sedating or other CNS effects.

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