Regulation of human basophil activationIII. Impairment of the inhibitory effect of Na+ on IgE-mediated histamine release in patients with allergic rhinitis

1992 ◽  
Vol 90 (1) ◽  
pp. 52-58 ◽  
Author(s):  
F BEAUVAIS ◽  
C HIEBLOT ◽  
C BURTIN ◽  
J BENVENISTE
Keyword(s):  
Allergic Rhinitis ◽  
Histamine Release ◽  
Inhibitory Effect ◽  
Human Basophil ◽  
Ige Mediated

Aqueous Extract of Mosla chinensis Inhibits Mast Cell-Mediated Allergic Inflammation

2012 ◽  
Vol 40 (06) ◽  
pp. 1257-1270 ◽  
Author(s):  
Hui-Hun Kim ◽  
Jin-Su Yoo ◽  
Tae-Yong Shin ◽  
Sang-Hyun Kim
Keyword(s):  
Mast Cell ◽  
Mast Cells ◽  
Histamine Release ◽  
Aqueous Extract ◽  
Proinflammatory Cytokines ◽  
Immunoglobulin E ◽  
Inflammatory Diseases ◽  
Allergic Inflammation ◽  
Inhibitory Effect ◽  
Ige Mediated

Allergic inflammatory diseases such as food allergy, asthma, sinusitis, and atopic dermatitis are increasing worldwide. In this study, we investigated the effects of aqueous extract of Mosla chinensis Max. (AMC) on mast cell-mediated allergic inflammation and studied the possible mechanism of this action. AMC inhibited compound 48/80-induced systemic and immunoglobulin E (IgE)-mediated local anaphylaxis. AMC reduced intracellular calcium levels and downstream histamine release from rat peritoneal mast cells activated by compound 48/80 or IgE. In addition, AMC decreased gene expression and secretion of proinflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-6 and IL-8 in human mast cells. The inhibitory effect of AMC on cytokine expression was nuclear factor (NF)-κB dependent. Our results indicate that AMC inhibits mast cell-mediated allergic inflammatory reaction by suppressing histamine release and expression of proinflammatory cytokines and the involvement of calcium and NF-κB in these effects. AMC might be a possible therapeutic candidate for allergic inflammatory disorders.

Inhibition of IgE- and non-IgE-mediated histamine release from human basophil leukocytes in vitro by a histamine H1-antagonist, desethoxycarbonyl-loratadine

1994 ◽  
Vol 93 (2) ◽  
pp. 494-500 ◽  
Author(s):  
Jörg Kleine-Tebbe ◽  
Christa Josties ◽  
Gabriel Frank ◽  
Dirk Stalleicken ◽  
Armin Buschauer ◽  
...  
Keyword(s):  
Histamine Release ◽  
Human Basophil ◽  
Ige Mediated ◽  
H1 Antagonist

scholarly journals Effects of in vivo administration of interleukin-2 (IL-2) and IL-4, alone and in combination, on ex vivo human basophil histamine release

Blood ◽  
1992 ◽  
Vol 79 (6) ◽  
pp. 1491-1495 ◽  
Author(s):  
MV White ◽  
Y Igarashi ◽  
BE Emery ◽  
MT Lotze ◽  
MA Kaliner
Keyword(s):  
Histamine Release ◽  
Ex Vivo ◽  
Interleukin 2 ◽  
Calcium Ionophore ◽  
Calcium Ionophore A23187 ◽  
Human Basophil ◽  
Control Group ◽  
Ionophore A23187 ◽  
Ige Mediated

Abstract Human basophils possess receptors for interleukin-2 (IL-2) and IL-4. The effect of 3 days of intravenous administration of IL-2 and/or IL-4 on basophil histamine release was examined in three groups of patients receiving IL-2, IL-4, or the combination of agents as part of a protocol to treat malignant melanoma or renal cell carcinoma. Because all patients received ranitidine for control of side effects, a control group of patients receiving ranitidine for Zollinger-Ellison's syndrome was also studied. IL-4 significantly inhibited IgE-mediated histamine release, while there was a trend for enhancement of IgE-mediated histamine release by IL-2. Administration of the combination of IL-2 and IL-4 did not alter IgE-mediated basophil histamine release. Both IL- 2 and IL-4, alone and in combination, enhanced basophil histamine release induced by histamine releasing factors in human nasal washings. The effect of IL-2 alone was significantly greater than that of IL-4 alone or the combination of IL-2 plus IL-4. Taken together, the data suggest that when coadministered, IL-4 may inhibit the effects of IL-2 on basophils. Neither cytokine exerted any effect on basophil histamine release induced by the calcium ionophore A23187, nor did ranitidine cause any effects on histamine release induced by any of the stimulants. Thus, human basophil reactivity can be affected by IL-2 and by IL-4. The role that these two cytokines play in basophil function in vivo is likely to be complex.

Clonidine inhibits IgE-mediated and IgE-independent in vitro histamine release from human basophil leukocytes

1989 ◽  
Vol 11 (5) ◽  
pp. 473-477 ◽  
Author(s):  
A. Miadonna ◽  
A. Tedeschi ◽  
E. Leggieri ◽  
P. Parravicini ◽  
M. Lorini ◽  
...  
Keyword(s):  
Histamine Release ◽  
Human Basophil ◽  
Ige Mediated

scholarly journals Effects of in vivo administration of interleukin-2 (IL-2) and IL-4, alone and in combination, on ex vivo human basophil histamine release

Blood ◽  
1992 ◽  
Vol 79 (6) ◽  
pp. 1491-1495
Author(s):  
MV White ◽  
Y Igarashi ◽  
BE Emery ◽  
MT Lotze ◽  
MA Kaliner
Keyword(s):  
Histamine Release ◽  
Ex Vivo ◽  
Interleukin 2 ◽  
Calcium Ionophore ◽  
Calcium Ionophore A23187 ◽  
Human Basophil ◽  
Control Group ◽  
Ionophore A23187 ◽  
Ige Mediated

Human basophils possess receptors for interleukin-2 (IL-2) and IL-4. The effect of 3 days of intravenous administration of IL-2 and/or IL-4 on basophil histamine release was examined in three groups of patients receiving IL-2, IL-4, or the combination of agents as part of a protocol to treat malignant melanoma or renal cell carcinoma. Because all patients received ranitidine for control of side effects, a control group of patients receiving ranitidine for Zollinger-Ellison's syndrome was also studied. IL-4 significantly inhibited IgE-mediated histamine release, while there was a trend for enhancement of IgE-mediated histamine release by IL-2. Administration of the combination of IL-2 and IL-4 did not alter IgE-mediated basophil histamine release. Both IL- 2 and IL-4, alone and in combination, enhanced basophil histamine release induced by histamine releasing factors in human nasal washings. The effect of IL-2 alone was significantly greater than that of IL-4 alone or the combination of IL-2 plus IL-4. Taken together, the data suggest that when coadministered, IL-4 may inhibit the effects of IL-2 on basophils. Neither cytokine exerted any effect on basophil histamine release induced by the calcium ionophore A23187, nor did ranitidine cause any effects on histamine release induced by any of the stimulants. Thus, human basophil reactivity can be affected by IL-2 and by IL-4. The role that these two cytokines play in basophil function in vivo is likely to be complex.

Influenza A virus enhances IgE-mediated histamine release from human basophil leukocytes. Examination of the effect of viral neuraminidase and haemagglutinin

1989 ◽  
Vol 27 (1-2) ◽  
pp. 58-61 ◽  
Author(s):  
P. Clementsen ◽  
A. R. Douglas ◽  
J. J. Skehel ◽  
C. Hannoun ◽  
N. Bach-Mortensen ◽  
...  
Keyword(s):  
Histamine Release ◽  
Influenza A Virus ◽  
Influenza A ◽  
Human Basophil ◽  
Ige Mediated
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