Redox regulation of stem cell mobilizationThis article is one of a selection of papers published in a special issue on Advances in Cardiovascular Research.

2009 ◽  
Vol 87 (12) ◽  
pp. 989-995 ◽  
Author(s):  
Istvan Lekli ◽  
Narasimman Gurusamy ◽  
Diptarka Ray ◽  
Arpad Tosaki ◽  
Dipak K. Das

A growing body of evidence supports the role of redox signaling in the mechanisms of hematopoietic stem cell mobilization and homing. Cytokines and adhesion molecules control stem cell mobilization through a redox-regulated process. The FoxO–SirT network appears to be intimately involved in redox-regulated stem cell homeostasis, whereas the process of stem cell differentiation is regulated by redox effector factor-1 (Ref-1) protein. Lack of oxygen (hypoxia), specifically controlled hypoxia, can stimulate the growth of the stem cells in their niche, and hypoxia-inducible factor (HIF)-1α appears to play a significant role in their maintenance and homing mechanism.

2013 ◽  
Vol 19 (3) ◽  
pp. 8-16 ◽  
Author(s):  
Fakhredin Saba ◽  
Masoud Soleimani ◽  
Amir Atashi ◽  
Esmaeil Mortaz ◽  
Mohammad Shahjahani ◽  
...  

2017 ◽  
Vol 36 (4) ◽  
pp. 399-409 ◽  
Author(s):  
Pantelis Tsirkinidis ◽  
Evangelos Terpos ◽  
Georgios Boutsikas ◽  
Athanasios Papatheodorou ◽  
Konstantinos Anargyrou ◽  
...  

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