<div>This paper describes recent
improvements made to the BCL::Conf rotamer generation algorithm and comparison
of its performance against other freely available and commercial conformer
generation software. We demonstrate that BCL::Conf, with the use of
rotamers derived from the COD, more effectively recovers crystallographic
ligand-binding conformations seen in the PDB than other commercial and freely
available software. BCL::Conf is now distributed with the COD-derived rotamer
library, free for academic use. The BCL can be downloaded at <a href="http://meilerlab.org/index.php/bclcommons/show/b_apps_id/1">http://meilerlab.org/
bclcommons</a> for Windows, Linux, or Apple operating systems.<br></div>
