Integrative parameter of platelet aggregation in intensive care of COVID-19 patients

Objective. To conduct a comparative analysis of changes in platelet aggregation parameters in COVID-19 patients which are related to anticoagulant therapy and to determine the effectiveness of the integrative parameter of platelet aggregation.Materials and methods. 34 patients with confirmed COVID-19 (group 1) were included into the study. To compare the obtained results, healthy females were included into group 2 (n = 30). The following parameters of aggregation were determined: degree, time, rate and area of aggregation (until its maximum degree).Results. The area of aggregation is the best among all the parameters of platelet aggregation to diagnose COVID-19 in patients according to the Hosmer-Lemeshow test: with an ADP inducer — 0.3 μg/ml (Chi-square = 9.481, p = 0.303); ADP — 1.25 μg/ml (Chi square = 12.577, p = 0.127); ADP — 2.5 μg/ml (Chi-square = 6.226, p = 0.622); adrenaline — 2.5 μM (Chi-square = 7.367, p = 0.498); adrenaline — 5 μM (Chi-square = 6.824, p = 0.556).Conclusion. The area of aggregation is an informative integrative parameter that allows to quantify the degree of aggregation in the treatment of hypercoagulation syndrome in COVID-19 patients.

Pengaruh Respon Time Perawat Terhadap Tingkat Kepuasan Pasien Dalam Pelayanan Pasien di Ruang IGD Rumah Sakit Aminah Kota Tangerang

ABSTRACT : EFFECT OF NURSE'S RESPONSE TIME ON SATISFACTION LEVEL PATIENTS IN PATIENT SERVICES IN THE EMERGENCY ROOM OFTHE HOSPITAL AMINAH TANGERANG CITY Introduction : Response time is the speed in handling patients, calculated from the time the patient arrives until there is a response from the nurse, the response time of the nurse will affect the satisfaction of the patient's and patient's family based on meeting or exceeding the expectations of the patient and family. Purpose: This study aims to identify the effect of the nurse's response time on the level of patient satisfaction in patient service in the emergency room at Aminah Hospital, Tangerang City.), Method: the sampling technique uses Systematic random sampling. Researchers collected data using instruments about patient satisfaction in this study using a standardized questionnaire, namely the questionnaire of the gap model of the Supriyanto questionnaire (2015). Meanwhile, the response time instrument used the first emergency service observation sheet or emergency response time rate. statistical test using the Spearman Rank statistical test. Result : Based on the research results obtained with a value of p = 0.000. Because the p value = 0.000 or <0.05. Conclusion : there is a significant relationship between the response time of the nurse to the level of patient satisfaction in patient service in the emergency room at Aminah Hospital, Tangerang City. Keyword: Nurse's Response and Satisfaction Level INTISARI: PENGARUH RESPON TIME PERAWAT TERHADAP TINGKAT KEPUASAN PASIEN DALAM PELAYANAN PASIEN DI RUANG IGD RUMAH SAKIT AMINAH KOTA TANGERANG Latar Belakang : Response time merupakan kecepatan dalam penanganan pasien, dihitung sejak pasien datang sampai adanya tanggapan dari perawat, respon time perawat akan berpengaruh terhadap Kepuasan keluarga pasien dan pasien didasarkan pada terpenuhi atau terlampauinya harapan pasien dan keluarga.Tujuan : Penelitian ini bertujuan mengidentifikasi Pengaruh Respon Time Perawat Terhadap Tingkat Kepuasan Pasien Dalam Pelayanaan Pasien di Ruang IGD Rumah Sakit Aminah Kota Tangerang Tahun 2021, terdapat 90 pasien di Ruang IGD berpartisipasi dalam penelitian ini.Metode penelitian : Jenis penelitian korelasional, dengan metode kuantitatif Eksperimen semu (Quasy experimental),teknik pengambilan sampel menggunakan Systematic random sampling. Peneliti melakukan pengumpulan data dengan menggunakan Instrumen tentang kepuasan pasien pada penelitian ini menggunakan kuisioner yang sudah baku yaitu kuisioner model kesenjangan kuisioner Supriyanto (2015) Sedangkan untuk intrumen Respon Time menggunakan lembar observasi pelayanan pertama gawat darurat atau emergency respon time rate. uji statistik menggunakan uji statistik Spearman RankHasil : Berdasarkan hasil penelitian didapatkan dengan nilai p= 0,000. Karena nilai p value = 0,000 atau <0,05.Kesimpulan : terdapat hubungan yang signifikan antara Respon Time Perawat Terhadap Tingkat Kepuasan Pasien Dalam Pelayanaan Pasien di Ruang IGD Rumah Sakit Aminah Kota Tangerang Kata kunci: Respon Perawat dan Tingkat Kepuasan

Physics-based secular variation candidate models for the IGRF

Each International Geomagnetic Reference Field (IGRF) model released under the auspices of the International Association of Geomagnetism and Aeronomy comprises a secular variation component that describes the evolution of the main magnetic field anticipated for the 5 years to come. Every Gauss coefficient, up to spherical harmonic degree and order 8, is assumed to undergo its own independent linear evolution. With a mathematical model of the core magnetic field and its time rate of change constructed from geomagnetic observations at hand, a standard prediction of the secular variation (SV) consists of taking the time rate of change of each Gauss coefficient at the final time of analysis as the predicted rate of change. The last three generations of the IGRF have additionally witnessed a growing number of candidate SV models relying upon physics-based forecasts. This surge is motivated by satellite data that now span more than two decades and by the concurrent progress in the numerical modelling of Earth’s core dynamics. Satellite data reveal rapid (interannual) geomagnetic features whose imprint can be detrimental to the quality of the IGRF prediction. This calls for forecasting frameworks able to incorporate at least part of the processes responsible for short-term geomagnetic variations. In this letter, we perform a retrospective analysis of the performance of past IGRF SV models and candidates over the past 35 years; we emphasize that over the satellite era, the quality of the 5-year forecasts worsens at times of rapid geomagnetic changes. After the definition of the time scales that are relevant for the IGRF prediction exercise, we cover the strategies followed by past physics-based candidates, which we categorize into a “‘core–surface flow” family and a “dynamo” family, noting that both strategies resort to “input” models of the main field and its secular variation constructed from observations. We next review practical lessons learned from our previous attempts. Finally, we discuss possible improvements on the current state of affairs in two directions: the feasibility of incorporating rapid physical processes into the analysis on the one hand, and the accuracy and quantification of the uncertainty impacting input models on the other hand.

Efficacy of Acid-treated Sawdust in Decolourization of Tanning Wastewater

Colour removal from dye-bearing effluent is a serious challenge due to the difficulty in treating such wastewater by conventional treatment methods. The present investigation explores the decolourization of contaminated wastewater using acid-activated sawdust as an adsorbent. The physicochemical properties of wastewater samples labelled A, B, and C vizaverage temperature; pH; electrical conductivity; and total dissolved solids were determined using standard methods to be 302.63; 6.1; 284.47 µS/cm;35116.66 mg/L respectively. Colour removal efficiency of the adsorbent was studied under variable conditions (contact time, rate of agitation,loading). Experimental results demonstrated that the sawdust adsorbent has a significant capacity for colour removal from tannery effluent. There was significant variation in the absorbance of the treated samples. Adsorbent dose, stirring rate, and contact time were found to be directly proportional to colour removal while pH variation of the samples show that the effluents became less alkaline (slightly acidic) after decolourization.

Efficacy of Acid-Modified Sawdust in Decolourization of Tanning Waste Water

Colour removal from dye-bearing effluent is a serious challenge due to the difficulty in treating such wastewater by conventional treatment methods. The present investigation explores the decolourization of contaminated wastewater using saw dust as an adsorbent. The physicochemical properties of waste water samples labelled A, B and C viz average temperature; pH; electrical conductivity; and total dissolved solids were 302.63; 6.1; 284.47 µS/cm; 35116.66 mg/L respectively. Colour removal efficiency of the adsorbent was studied under variable conditions (contact time, rate of agitation, loading). Experimental results demonstrated that the sawdust adsorbent has a significant capacity for colour removal from tannery effluent. There was significant variation in the absorbance of the treated samples. Adsorbent dose, stirring rate and contact time showed significant effects in colour removal.

Growth & Determinants of Fertilizer Consumption in India: Application of Demand and Supply Side Models

This paper estimated the growth of fertilizer consumption in India and forecasted it upto the year 2030 and both supply side and demand side factors which influences it. The results indicated that consumption of fertilizers had been increased at the rate of 4.16 per cent. The demand side determinants like area under irrigation reflected at the rate of 1.42 per cent growth, average minimum support prices showed a growth rate of 7 per cent and a short term institutional credit registered a growth rate of 17 per cent. Area under irrigation and sum of average MSP encourages the fertilizer consumption substantially. The supply side factors viz., production, import and subsidy were influencing the fertilizer consumption significantly. The total fertilizer demand is expected to reach at 57 million tons by 2030 and at the same time, rate of consumption might enhanced to 277 kg per hectare. It is concluded that import is unavoidable to meet the gap between domestic production and total demand.

Quantitative Analysis of the QMS for Pharmaceutical Manufacturing

Purpose To propose a statistical methodology for quantitative analysis of the quality management system (QMS) of pharmaceutical manufacturing. Methods (1) Based on the manufacturing data from two established active pharmaceutical ingredient (API) manufacturers in China from 2010 to 2019, the linear regression with Pearson correlation coefficient is used to find the correlations between the proposed QMS operation indicators and performance indicators. (2) A stepwise multiple linear regression is used to identify the independent operation indicators with the biggest impact on a given performance indicator. (3) The Akaike Information Criterion is used to predict the performance indicators based on the operation indicators. Results (1) Correlation: the right-first-time rate correlates strongly with various changes and deviations; the customer complaints correlate with changes, deviations, and CAPAs; the deficiency rate of foreign inspections correlates with deviations and CAPAs; and the CAPA on-time completion rate correlates with changes, deviations, and the ratio of employees in quality. (2) Impact: the right-first-time rate and the customer complaints are mostly impacted by the total deviations; the deficiency rate of foreign inspections is mostly impacted by deviations in equipment and instrument, and deviations due to human error; the CAPA on-time completion rate is mainly impacted by deviations in facility and utilities. (3) Predictability: the right-first-time rate, the customer complaints, the deficiency rate of foreign inspections, and the CAPA on-time completion rate can all be predicted based on the existing data with statistical significance. Conclusions Deviations emerge as a key leading indicator for the performance of QMS. The proposed statistical methodology provides a basis for the data-driven quality management and regulation, whose visibility and predictability are likely to progress as the data accumulates.

ABLATIVE PRESSURE PULSE

<div> We examine herein a simple model for the evolution in time of the pressure which a suddenly vaporized, ablating layer exerts upon the subjacent body. The model invokes a plausible construct of surface material instantaneously thrust into a gaseous regime governed by a Maxwell-Boltzmann phase space distribution. The surface pressure <i>per se</i> is gotten by computing the time rate of change of the momentum per unit area which the retrograde molecules, and only those, transfer through impact/reflection to the unvaporized body below. An explicit pressure formula, one alluding to the variable gas temperature within the vaporized layer, is obtained as a single quadrature requiring numerical integra- tion at finite times past the onset of impact. Limiting, null pressure values, both close-in and in pulse aftermath, can nevertheless be extracted in analytic terms, confirming in particular the indispensable asymptotic evanescence. A universal formula in dimensionless variables is given for pressure versus time, both suitably normalized.</div>

ABLATIVE PRESSURE PULSE

<div> We examine herein a simple model for the evolution in time of the pressure which a suddenly vaporized, ablating layer exerts upon the subjacent body. The model invokes a plausible construct of surface material instantaneously thrust into a gaseous regime governed by a Maxwell-Boltzmann phase space distribution. The surface pressure <i>per se</i> is gotten by computing the time rate of change of the momentum per unit area which the retrograde molecules, and only those, transfer through impact/reflection to the unvaporized body below. An explicit pressure formula, one alluding to the variable gas temperature within the vaporized layer, is obtained as a single quadrature requiring numerical integra- tion at finite times past the onset of impact. Limiting, null pressure values, both close-in and in pulse aftermath, can nevertheless be extracted in analytic terms, confirming in particular the indispensable asymptotic evanescence. A universal formula in dimensionless variables is given for pressure versus time, both suitably normalized.</div>