Effect of VIP antagonist on VIP-, PGE2-, and acid-stimulated duodenal bicarbonate secretion

1989 ◽  
Vol 256 (5) ◽  
pp. G833-G836 ◽  
Author(s):  
M. C. Algazi ◽  
H. S. Chen ◽  
M. A. Koss ◽  
D. L. Hogan ◽  
J. Steinbach ◽  
...  
Keyword(s):  
Prostaglandin E2 ◽  
Vasoactive Intestinal Peptide ◽  
Bicarbonate Secretion ◽  
Anesthetized Rats ◽  
Duodenal Bicarbonate Secretion ◽  
Presence And Absence

Vasoactive intestinal peptide (VIP), prostaglandin E2 (PGE2), and luminal acidification are each potent stimulants of duodenal mucosal bicarbonate secretion. The present experiments were performed to determine whether the recently described VIP antagonist, [4Cl-D-Phe6,Leu17]VIP, suppresses VIP-stimulated duodenal mucosal bicarbonate secretion and to determine whether VIP serves as a mediator of bicarbonate secretion stimulated by acid or PGE2. In anesthetized rats, the effects of intravenous VIP, intraluminal PGE2, and intraluminal HCl on duodenal mucosal bicarbonate secretion both in the presence and absence of [4Cl-D-Phe6,Leu17]VIP were measured. The VIP antagonist inhibited duodenal bicarbonate secretion stimulated by both intravenous VIP and luminal acidification but not luminal PGE2. These findings suggest that VIP could be one mediator of acid-induced duodenal bicarbonate secretion and that the mechanism of PGE2-stimulated bicarbonate secretion is independent of VIP.

Basal and PGE2-stimulated duodenal bicarbonate secretion in the rat in vivo

1988 ◽  
Vol 255 (4) ◽  
pp. G470-G475 ◽  
Author(s):  
J. R. Heylings ◽  
M. Feldman
Keyword(s):  
Prostaglandin E2 ◽  
Intravenous Administration ◽  
Concentration Gradient ◽  
Bicarbonate Secretion ◽  
Dependent Process ◽  
Duodenal Bicarbonate Secretion ◽  
Presence And Absence ◽  
Energy Dependent

We studied basal and prostaglandin E2 (PGE2)-stimulated duodenal HCO3- transport in the rat in vivo both in the presence and absence of a concentration gradient for HCO3- from blood to lumen. Basal HCO3- transport was not reduced when the luminal solution was changed from one containing 0 mM HCO3- to one containing 22 mM HCO3- either at pH 9.0 or 7.5. Thus basal duodenal HCO3- transport in rats is independent of a blood-to-lumen HCO3- concentration gradient, which indicates an energy-dependent process with little passive flux of HCO3-. Luminal or intravenous administration of PGE2 significantly (P less than 0.01) increased HCO3- secretion into a HCO3(-)-free luminal solution but had no effect on HCO3- secretion into luminal solutions containing 22 mM HCO3-, either at pH 9.0 or 7.5. Therefore prostaglandins may act by increasing passive flux of HCO3- rather than by stimulating energy-dependent duodenal HCO3- transport.

The Effect of Vasoactive Intestinal Peptide, Secretin, and Glucagon on Human Duodenal Bicarbonate Secretion

1989 ◽  
Vol 24 (2) ◽  
pp. 151-157 ◽  
Author(s):  
J. D. Wolosin ◽  
F. J. Thomas ◽  
D. L. Hogan ◽  
M. A. Koss ◽  
T. M. O'dorisio ◽  
...  
Keyword(s):  
Vasoactive Intestinal Peptide ◽  
Bicarbonate Secretion ◽  
Duodenal Bicarbonate Secretion

The role of SLC26A6 and CFTR in acid-induced and prostaglandin E2-stimulated duodenal bicarbonate secretion in vivo

2007 ◽  
Vol 45 (08) ◽  
Author(s):  
A Singh ◽  
M Sjöblom ◽  
A Krabbenhöft ◽  
B Riederer ◽  
MP Manns ◽  
...  
Keyword(s):  
Prostaglandin E2 ◽  
Bicarbonate Secretion ◽  
Duodenal Bicarbonate Secretion

scholarly journals The role of cGMP-cGKI-signaling for duodenal bicarbonate secretion

2009 ◽  
Vol 9 (S1) ◽  
Author(s):  
Beate Spiessberger ◽  
Pascal Weinmeister ◽  
Franz Hofmann ◽  
Claudia Werner ◽  
Dieter Saur ◽  
...  
Keyword(s):  
Bicarbonate Secretion ◽  
Duodenal Bicarbonate Secretion

Neuronal cGMP kinase I is essential for stimulation of duodenal bicarbonate secretion by luminal acid

2012 ◽  
Vol 26 (4) ◽  
pp. 1745-1754 ◽  
Author(s):  
Anurag Kumar Singh ◽  
Beate Spieβberger ◽  
Wen Zheng ◽  
Fang Xiao ◽  
Robert Lukowski ◽  
...  
Keyword(s):  
Bicarbonate Secretion ◽  
Duodenal Bicarbonate Secretion ◽  
Stimulation Of
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