Heart rate during exercise with leg vascular occlusion in spinal cord-injured humans

1999 ◽  
Vol 86 (3) ◽  
pp. 806-811 ◽  
Author(s):  
M. Kjær ◽  
F. Pott ◽  
T. Mohr ◽  
P. Linkis ◽  
P. Tornøe ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Spinal Cord ◽  
Heart Rate ◽  
Oxygen Uptake ◽  
Heart Rate Response ◽  
Vascular Occlusion ◽  
Voluntary Exercise ◽  
Feedback Mechanisms ◽  
Cord Injury ◽  
Neural Feedback

Feed-forward and feedback mechanisms are both important for control of the heart rate response to muscular exercise, but their origin and relative importance remain inadequately understood. To evaluate whether humoral mechanisms are of importance, the heart rate response to electrically induced cycling was studied in participants with spinal cord injury (SCI) and compared with that elicited during volitional cycling in able-bodied persons (C). During voluntary exercise at an oxygen uptake of ∼1 l/min, heart rate increased from 66 ± 4 to 86 ± 4 (SE) beats/min in seven C, and during electrically induced exercise at a similar oxygen uptake in SCI it increased from 73 ± 3 to 110 ± 8 beats/min. In contrast, blood pressure increased only in C (from 88 ± 3 to 99 ± 4 mmHg), confirming that, during exercise, blood pressure control is dominated by peripheral neural feedback mechanisms. With vascular occlusion of the legs, the exercise-induced increase in heart rate was reduced or even eliminated in the electrically stimulated SCI. For C, heart rate tended to be lower than during exercise with free circulation to the legs. Release of the cuff elevated heart rate only in SCI. These data suggest that humoral feedback is of importance for the heart rate response to exercise and especially so when influence from the central nervous system and peripheral neural feedback from the working muscles are impaired or eliminated during electrically induced exercise in individuals with SCI.

Diurnal Blood Pressure Variation in Quadriplegic Chronic Spinal Cord Injury Patients

1991 ◽  
Vol 80 (3) ◽  
pp. 271-276 ◽  
Author(s):  
Henry Krum ◽  
William J. Louis ◽  
Douglas J. Brown ◽  
Graham P. Jackman ◽  
Laurence G. Howes
Keyword(s):  
Blood Pressure ◽  
Spinal Cord ◽  
Heart Rate ◽  
Spinal Cord Injury ◽  
Ambulatory Monitoring ◽  
Pressure Variation ◽  
Night Time ◽  
Cord Injury ◽  
Blood Pressure Variation ◽  
Neurologically Intact

1. Measurement of blood pressure and heart rate over a 24 h period was peformed in 10 quadriplegic spinal cord injury patients and 10 immobilized, neurologically intact orthopaedic subjects by using the Spacelabs 90207 automated ambulatory monitoring system. 2. Systolic and diastolic blood pressure fell significantly at night in orthopaedic subjects but not in quadriplegic patients, and night-time blood pressures were similar in both groups. 3. Cumulative summation of differences from a reference value (cusum analysis) confirmed a markedly diminished diurnal blood pressure variation in the quadriplegic patients. 4. These findings could not be accounted for on the basis of blood pressure variations during chronic postural change. 5. Heart rate fell significantly at night in both groups. 6. The findings suggest that the increase in blood pressure during waking hours in neurologically intact subjects is a consequence of a diurnal variation in sympathetic activity (absent in quadriplegic patients with sympathetic decentralization) which is independent of changes in physical activity.

Autonomic dysreflexia during sperm retrieval in spinal cord injury: influence of lesion level and sildenafil citrate

2005 ◽  
Vol 99 (1) ◽  
pp. 53-58 ◽  
Author(s):  
A. William Sheel ◽  
Andrei V. Krassioukov ◽  
J. Timothy Inglis ◽  
Stacy L. Elliott
Keyword(s):  
Blood Pressure ◽  
Spinal Cord ◽  
Heart Rate ◽  
Spinal Cord Injury ◽  
Autonomic Dysreflexia ◽  
Sildenafil Citrate ◽  
Vibratory Stimulation ◽  
Arterial Blood ◽  
Cord Injury ◽  
Penile Vibratory Stimulation

Autonomic dysreflexia (AD) can occur during penile vibratory stimulation in men with spinal cord injury, but this is variable, and the association with lesion level is unclear. The purpose of this study was to characterize the cardiovascular responses to penile vibratory stimulation in men with spinal cord injury. We hypothesized that those with cervical injuries would demonstrate a greater degree of AD compared with men with thoracic injuries. We also questioned whether the rise in blood pressure could be attenuated by sildenafil citrate. Participants were classified as having cervical ( n = 8) or thoracic ( n = 5) injuries. While in a supine position, subjects were instrumented with an ECG, and arterial blood pressure was determined beat by beat. Subjects reported to the laboratory twice and received an oral dose of sildenafil citrate (25–100 mg) or no medication. Penile vibratory stimulation was performed using a handheld vibrator to the point of ejaculation. At ejaculation during the nonmedicated trials, the cervical group had a significant decrease in heart rate (−5–10 beats/min) and increase in mean arterial blood pressure (+70–90 mmHg) relative to resting conditions, whereas the thoracic group had significant increases in both heart rate (+8–15 beats/min) and mean arterial pressure (+25–30 mmHg). Sildenafil citrate had no effect on the change in heart rate or mean arterial pressure in either group. In summary, men with cervical injuries had more pronounced AD during penile vibratory stimulation than men with thoracic injuries. Administration of sildenafil citrate had no effect on heart rate or blood pressure during penile vibratory stimulation in men with spinal cord injury.

scholarly journals Prevalence of Autonomic Dysreflexia in Patients with Spinal Cord Injury above T6

2017 ◽  
Vol 2017 ◽  
pp. 1-6 ◽  
Author(s):  
Eun Sun Lee ◽  
Min Cheol Joo
Keyword(s):  
Blood Pressure ◽  
Spinal Cord ◽  
Heart Rate ◽  
Spinal Cord Injury ◽  
Ambulatory Blood Pressure ◽  
Blood Pressure Monitoring ◽  
Autonomic Dysreflexia ◽  
Therapeutic Interventions ◽  
Pressure Monitoring ◽  
Cord Injury

Objective. To investigate the prevalence of autonomic dysreflexia (AD) using ambulatory blood pressure monitoring (ABPM) and the autonomic dysfunction following spinal cord injury (ADFSCI) questionnaire in patients with spinal cord injury (SCI) above T6.Methods. Twenty-eight patients diagnosed with SCI above T6 were enrolled. ABPM and ADFSCI were utilized to assess AD. Using ABPM, systolic blood pressure (SBP), diastolic blood pressure, and heart rate (HR) were measured at 30-minute intervals. AD was defined as SBP 20 mmHg higher than basal SBP, and the number of AD events was counted. The ADFSCI questionnaire evaluates the severity and frequency of the AD symptoms.Results. According to the ABPM, AD occurred in 26 patients and AD events occurred5.8±4.7times. Average daytime and nighttime SBP were119.9±18.8 mmHg and123.8±21.2 mmHg, respectively, and the nighttime mean SBP appeared to be 4 mmHg higher than daytime mean SBP. These findings suggest the loss of nocturnal BP dipping in SCI patients. ADFSCI results revealed that 16 of the patients evaluated were symptomatic while 12 were asymptomatic.Conclusion. AD following SCI above T6 was highly prevalent and several patients seemed asymptomatic. These results suggest the necessity of proper diagnostic and therapeutic interventions for managing AD.

Oxygen uptake and heart rate relationship in persons with spinal cord injury

1993 ◽  
Vol 25 (10) ◽  
pp. 1115???1119 ◽  
Author(s):  
STEVEN P. HOOKER ◽  
JOHN D. GREENWOOD ◽  
DAVID T. HATAE ◽  
ROXANNE P. HUSSON ◽  
TRACI L. MATTHIESEN ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Heart Rate ◽  
Spinal Cord Injury ◽  
Oxygen Uptake ◽  
Cord Injury ◽  
Rate Relationship

scholarly journals Normative Blood Pressure and Heart Rate in Pediatric Spinal Cord Injury

2013 ◽  
Vol 19 (2) ◽  
pp. 87-95 ◽  
Author(s):  
Miriam Hwang ◽  
Kathy Zebracki ◽  
Randal Betz ◽  
M.J. Mulcahey ◽  
Lawrence Vogel
Keyword(s):  
Blood Pressure ◽  
Spinal Cord ◽  
Heart Rate ◽  
Spinal Cord Injury ◽  
Cord Injury ◽  
Pediatric Spinal Cord Injury
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