Effects of Endothelin-1 on Hepatic Blood Flow

Endothelin-1 belongs to a family of potent vasoconstrictors, recently isolated from endothelial cells. Endothelin-1 has a variety of hepatic effects and hepatic clearance from the circulation is important. Elevated plasma concentrations of Endothelin-1 are found after orthotopic liver transplantation and in cirrhosis with ascites.This study in piglets on hepatic bloodflow was designed to compare differences in effects between central venous and intraportal injection of endothelin-1, and to evaluate effects of repeated injections. Central venous injection of endothelin-1 caused a larger reduction in portal vein flow, while intraportal injection caused a larger increase in portal vein pressure. Repeated injections resulted in a reduction in portal vein flow and an increase in portal vein vascular resistance.

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Optimal Central Venous Pressure During the Neohepatic Phase to Decrease Peak Portal Vein Flow Velocity for the Prevention of Portal Hyperperfusion in Patients Undergoing Living Donor Liver Transplantation

Transplantation Proceedings ◽

10.1016/j.transproceed.2014.10.071 ◽

2015 ◽

Vol 47 (4) ◽

pp. 1194-1198 ◽

Cited By ~ 2

Author(s):

T.H. Ryu ◽

J.Y. Jung ◽

D.L. Choi ◽

Y.S. Han ◽

J.D. Kim ◽

...

Keyword(s):

Liver Transplantation ◽

Portal Vein ◽

Central Venous Pressure ◽

Living Donor ◽

Living Donor Liver Transplantation ◽

Venous Pressure ◽

Donor Liver ◽

Central Venous ◽

Donor Liver Transplantation ◽

Portal Vein Flow

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Measurement of liver volumes by portal vein flow by Doppler ultrasound in living donor liver transplantation

Clinical Transplantation ◽

10.1111/ctr.13050 ◽

2017 ◽

Vol 31 (9) ◽

pp. e13050 ◽

Cited By ~ 2

Author(s):

Sang Hyun Choi ◽

Jae Hyun Kwon ◽

Kyoung Won Kim ◽

Hye Young Jang ◽

Ji Hye Kim ◽

...

Keyword(s):

Liver Transplantation ◽

Portal Vein ◽

Doppler Ultrasound ◽

Living Donor ◽

Living Donor Liver Transplantation ◽

Donor Liver ◽

Donor Liver Transplantation ◽

Portal Vein Flow

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Intra-operative management of low portal vein flow in pediatric living donor liver transplantation

Transplant International ◽

10.1111/j.1432-2277.2012.01464.x ◽

2012 ◽

Vol 25 (5) ◽

pp. 586-591 ◽

Cited By ~ 8

Author(s):

Ting-Lung Lin ◽

Li-Wei Chiang ◽

Chao-Long Chen ◽

Shih-Hor Wang ◽

Chih-Che Lin ◽

...

Keyword(s):

Liver Transplantation ◽

Portal Vein ◽

Living Donor ◽

Living Donor Liver Transplantation ◽

Operative Management ◽

Donor Liver ◽

Donor Liver Transplantation ◽

Portal Vein Flow

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Correction of extrahepatic portal hypertension in pediatric patient after liver transplantation

Russian Journal of Transplantology and Artificial Organs ◽

10.15825/1995-1191-2017-1-47-51 ◽

2017 ◽

Vol 19 (1) ◽

pp. 47-51

Author(s):

A. R. Monakhov ◽

B. L. Mironkov ◽

T. A. Dzhanbekov ◽

K. O. Semash ◽

Kh. M. Khizroev ◽

...

Keyword(s):

Liver Transplantation ◽

Blood Flow ◽

Portal Hypertension ◽

Portal Vein ◽

Pediatric Patient ◽

Portal Blood Flow ◽

Portal Blood ◽

Positive Trend ◽

Portal Vein Stenosis ◽

Vein Stenosis

Introduction. Liver transplantation is a multi-component and complex type of operative treatment. Patients undergoing such a treatment sometimes are getting various complications. One of these complications is a portal hypertension associated with portal vein stenosis.Materials and methods. In 6 years after the left lateral section transplantation from living donor in a pediatric patient the signs of portal hypertension were observed. Stenosis of the portal vein was revealed. Due to this fact percutaneous transhepatic correction of portal vein stenosis was performed.Results. As a result of the correction of portal blood flow in the patient a positive trend was noted. According to the laboratory and instrumental methods of examination the graft had a normal function, portal blood flow was adequate. In order to control the stent patency Doppler ultrasound and MSCT of the abdominal cavity with intravenous bolus contrasting were performed. Due to these examinations the stent function was good, the rate of blood flow in the portal vein due to Doppler data has reached 80 cm/sec, and a decrease of the spleen size was noted.Conclusion. Diagnosis and timely detection of portal vein stenosis in patients after liver transplantation are very important for the preservation of graft function and for the prevention of portal hypertension. In order to do that, ultrasound Doppler fluorimetry examination needs to be performed to each patient after liver transplantation. In cases of violation of the blood flow in the portal vein CT angiography performance is needed. Percutaneous transhepatic stenting of portal vein is a minimally invasive and highly effective method of correction of portal hypertension. Antiplatelet therapy and platelet aggregation control are the prerequisites for successful stent function.

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Computational Fluid Dynamics-Based Blood Flow Assessment Facilitates Optimal Management of Portal Vein Stenosis After Liver Transplantation

Journal of Gastrointestinal Surgery ◽

10.1007/s11605-019-04279-w ◽

2019 ◽

Vol 24 (2) ◽

pp. 460-461

Author(s):

Satoshi Ogiso ◽

Masanori Nakamura ◽

Takashi Tanaka ◽

Kenji Komiya ◽

Hideya Kamei ◽

...

Keyword(s):

Fluid Dynamics ◽

Computational Fluid Dynamics ◽

Liver Transplantation ◽

Blood Flow ◽

Portal Vein ◽

Optimal Management ◽

Portal Vein Stenosis ◽

Vein Stenosis

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Selective Hemi-Portocaval Shunt Based on Portal Vein Pressure for Small-for-Size Graft in Adult Living Donor Liver Transplantation

American Journal of Transplantation ◽

10.1111/j.1600-6143.2007.02144.x ◽

2008 ◽

Vol 8 (4) ◽

pp. 847-853 ◽

Cited By ~ 89

Author(s):

T. Yamada ◽

K. Tanaka ◽

K. Uryuhara ◽

K. Ito ◽

Y. Takada ◽

...

Keyword(s):

Liver Transplantation ◽

Portal Vein ◽

Living Donor ◽

Living Donor Liver Transplantation ◽

Portocaval Shunt ◽

Donor Liver ◽

Portal Vein Pressure ◽

Donor Liver Transplantation ◽

Small For Size

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Haemodynamic Effects of Eating: The Role of Meal Composition

Clinical Science ◽

10.1042/cs0900269 ◽

1996 ◽

Vol 90 (4) ◽

pp. 269-276 ◽

Cited By ~ 45

Author(s):

U. Høst ◽

H. Kelbaek ◽

H. Rasmusen ◽

M. Court-Payen ◽

N. Juel Christensen ◽

...

Keyword(s):

Blood Flow ◽

Cardiac Output ◽

Portal Vein ◽

Forearm Blood Flow ◽

Plasma Catecholamines ◽

Left Ventricular ◽

Gastric Distension ◽

Left Ventricular Volumes ◽

Portal Vein Flow

1. The purpose of this study was to investigate the effect of fractional meal stimulation on postprandial haemodynamic changes, the possible correlation between these changes and the potential mediating role of circulating catecholamines and insulin. 2. Healthy young subjects were studied before and after ingestion of isocaloric, isovolumetric high-protein, carbohydrate or fat meals (80–85% of total energy), 60 kJ per kg of body weight. Multigated radionuclide cardiography with autologous 99mTc-labelled erythrocytes was performed for assessment of cardiac output, venous occlusion plethysmography to obtain forearm blood flow and Doppler-ultrasonography for portal vein flow. Plasma levels of catecholamines and insulin were determined by radioimmunoassay. 3. Cardiac output increased considerably after each meal, including the control meal (water) with only minor differences in extent and timing. Left ventricular volumes increased after food intake, most pronounced after carbohydrate and protein. Forearm blood flow increased only after carbohydrate and protein. Portal vein flow increased after all meals, especially after fat, but also after the control meal. There was a significant correlation between the increment in cardiac output and changes in forearm and portal vein flow, but no correlation between either haemodynamic response and plasma catecholamines or insulin. 4. Postprandial cardiovascular changes are not substantially different after various isocaloric and isovolumic meal compositions. Gastric distension seems to play a role in the increase in cardiac output, accomplished by ventricular dilatation. These changes seem to some extent to be linked to changes in muscle and splanchnic flow.

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