Serological Testing in Screening for Adult Celiac Disease

Assays for celiac-related antibodies are becoming widely available, and the present review aims to clarify the use of these investigations in the diagnosis of, management of and screening for adult celiac disease. The sensitivities and specificities of various antibody tests are discussed, along with their clinical use as an adjunct to small bowel biopsy, and as a first-line investigation for patients with atypical symptoms of celiac disease or patients at high risk of developing sprue.

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REVIEW: Adult Celiac Disease and the Severe “Flat” Small Bowel Biopsy Lesion

Digestive Diseases and Sciences ◽

10.1023/b:ddas.0000026295.64670.d1 ◽

2004 ◽

Vol 49 (4) ◽

pp. 535-545 ◽

Cited By ~ 11

Author(s):

Hugh James Freeman

Keyword(s):

Celiac Disease ◽

Small Bowel ◽

Small Bowel Biopsy ◽

Adult Celiac Disease

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Sugar absorption by small bowel biopsy samples from patients with primary lactase deficiency and with adult celiac disease

The American Journal of Digestive Diseases ◽

10.1007/bf01071905 ◽

1976 ◽

Vol 21 (11) ◽

pp. 946-952 ◽

Cited By ~ 10

Author(s):

I. T. Beck ◽

P. K. Dinda ◽

L. R. Costa ◽

M. Beck

Keyword(s):

Celiac Disease ◽

Small Bowel ◽

Lactase Deficiency ◽

Small Bowel Biopsy ◽

Sugar Absorption ◽

Adult Celiac Disease

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Follow-up of Patients Positive in Reticulin and Gliadin Antibody Tests with Normal Small-Bowel Biopsy Findings

Scandinavian Journal of Gastroenterology ◽

10.3109/00365529309096094 ◽

1993 ◽

Vol 28 (7) ◽

pp. 595-598 ◽

Cited By ~ 93

Author(s):

P. Collin ◽

H. Helin ◽

M. Mäki ◽

O. Hällström ◽

A.-L. Karvonen

Keyword(s):

Small Bowel ◽

Small Bowel Biopsy ◽

Antibody Tests ◽

Gliadin Antibody

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Prevalence of Celiac Disease in Collagenous and Lymphocytic Colitis

Canadian Journal of Gastroenterology ◽

10.1155/2000/847807 ◽

2000 ◽

Vol 14 (11) ◽

pp. 919-921 ◽

Cited By ~ 31

Author(s):

Helen Rachel Gillett ◽

Hugh James Freeman

Keyword(s):

Celiac Disease ◽

Small Bowel ◽

Tissue Transglutaminase ◽

Immunoglobulin A ◽

Collagenous Colitis ◽

Lymphocytic Colitis ◽

Small Bowel Biopsy ◽

Major Antigen ◽

Immunofluorescent Technique ◽

Endomysium Antibody

Both collagenous and lymphocytic colitis have been described in patients with celiac disease, suggesting an association between the conditions. Over the past few years, the availability, sensitivity and specificity of serological markers for celiac disease have improved - the most recent advancement being the description of tissue transglutaminase as the major antigen for endomysium antibody. A quantitative ELISA was used to measure titres of immunoglobulin A (IgA) antibody to tissue transglutaminase (tTG) along with an immunofluorescent technique for IgA endomysium antibody (EmA) in 15 patients with lymphocytic colitis and eight with collagenous colitis to determine whether celiac disease latency could be detected. One patient with lymphocytic colitis demonstrated both elevated titres of tTG antibody and positive EmA, and small bowel biopsy confirmed celiac disease. One patient with collagenous colitis had a slightly elevated titre of tTG antibody with a negative EmA, and results of a small bowel biopsy were normal. Three other patients with lymphocytic colitis were already treated for previously diagnosed celiac disease. The prevalence of celiac disease occurring in lymphocytic colitis was found to be 27%, but no cases of celiac disease in association with collagenous colitis were found.

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Celiac Disease and Sensitization to Wheat, Rye, and Barley: Should We Be Concerned?

International Archives of Allergy and Immunology ◽

10.1159/000512108 ◽

2020 ◽

pp. 1-7

Author(s):

Camila Marques de Valois Lanzarin ◽

Natalia de Oliveira e Silva ◽

Maissara Obara Venturieri ◽

Dirceu Solé ◽

Ricardo Palmero Oliveira ◽

...

Keyword(s):

Celiac Disease ◽

Small Bowel ◽

Case Reports ◽

Serum Levels ◽

Specific Ige ◽

Age At Diagnosis ◽

Gluten Free ◽

Small Bowel Biopsy ◽

History Of ◽

Ige Mediated

Background: Concomitance of celiac disease (CD) and IgE-mediated wheat allergy is described in some case reports. The objective was to evaluate the frequency of sensitization to wheat, rye, barley, and malt in children and adolescents with CD. Methods: Measurement of serum levels of specific IgE to wheat, rye, barley, and malt (ImmunoCAP; sensitization IgE ≥0.35 kUA/L) in CD patients followed in specialized clinics to verify allergy history, general characteristics, small bowel biopsy characteristics, compliance with gluten-free diet (GFD), and occurrence of symptoms in case of noncompliance. Results: We evaluated 74 patients; the median of age and age at diagnosis of CD were 8.6 years (5.0–12.8) and 3.6 years (1.6–7.0), respectively. Median time of GFD was 3.5 years (1.4–5.8). History of asthma occurred in 17.3% of subjects, allergic rhinitis in 13.5%, and AD in 5.4%. Frequency of sensitization was 4% for wheat, 10.8% for rye, 5.4% for barley, and 2.7% for malt. There was no association between wheat sensitization and age at diagnosis, time of GFD, small bowel biopsy characteristics, allergy history, and gluten consumption. There was no relationship between sensitization to wheat and occurrence of immediate symptoms when not complying with GFD. Conclusion: In conclusion, the frequency of sensitization to wheat, rye, barley, and malt in CD patients was 4, 10.8, 5.4, and 2.7%, respectively. Therefore, to ensure that cutaneous and respiratory contact with wheat is safe, we advise patients with CD to investigate their sensitivity to wheat, rye, and barley because not all patients with CD are allergic to these cereals.

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