scholarly journals Potent Antifungal Activity of Pure Compounds from Traditional Chinese Medicine Extracts against Six OralCandidaSpecies and the Synergy with Fluconazole against Azole-ResistantCandida albicans

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Zhimin Yan ◽  
Hong Hua ◽  
Yanying Xu ◽  
Lakshman P. Samaranayake
Keyword(s):  
Chinese Medicine ◽  
Antifungal Activity ◽  
Traditional Chinese Medicine ◽  
Sjögren's Syndrome ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Hiv Positive ◽  
Pseudolaric Acid B ◽  
Hiv Negative ◽  
Sjögren‘S Syndrome

This study was designed to evaluate thein vitroantifungal activities of four traditional Chinese medicine (TCM) extracts. The inhibitory effects of pseudolaric acid B, gentiopicrin, rhein, and alion were assessed using standard disk diffusion and broth microdilution assays. They were tested against six oralCandidaspecies,Candida albicans, Candida glabrata, Candida tropicalis, Candida krusei, Candida dubliniensis,andCandida guilliermondii, including clinical isolates from HIV-negative, HIV-positive, and Sjögren's syndrome patients. It was found that pseudolaric acid B had the most potent antifungal effect and showed similar antifungal activity to all sixCandidaspp, and to isolates from HIV-negative, HIV-positive, and Sjögren's syndrome patients. The MIC values ranged from 16 to 128 μg/mL. More interestingly, a synergistic effect of pseudolaric acid B in combination with fluconazole was observed. We suggest that pseudolaric acid B might be a potential therapeutic fungicidal agent in treating oral candidiasis.

scholarly journals Treatment of Sjogren's Syndrome with Liver Depression

2021 ◽  
Vol 5 (1) ◽  
Author(s):  
Jiaqin Liu ◽  
Chunying Liu
Keyword(s):  
Chinese Medicine ◽  
Sjögren’S Syndrome ◽  
Sjögren's Syndrome ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Test Case ◽  
Old Chinese ◽  
Addition And Subtraction ◽  
Sjögren‘S Syndrome

Liu Chunying is a famous old Chinese medicine doctor for more than 30 years. He has rich experience in the understanding and treatment of Sjogren's syndrome (SS). Liu Shi systematically discusses the etiology and pathogenesis of SS from the angle of liver depression. In the treatment, it is emphasized that "Muyu Da Zhi" is the first, with the addition and subtraction of the disease, to provide a new idea for the treatment of Sjogren's syndrome from liver depression, and to attach a test case.

The association of Raynaud’s phenomenon/syndrome with scleroderma and Sjögren’s syndrome – a meta-analysis

VASA ◽  
2008 ◽  
Vol 37 (Supplement 73) ◽  
pp. 26-32 ◽  
Author(s):  
Schlattmann ◽  
Höhne ◽  
Plümper ◽  
Heidrich
Keyword(s):  
Quantitative Analysis ◽  
Sjögren’S Syndrome ◽  
Mixture Model ◽  
Sjögren's Syndrome ◽  
Meta Analysis ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Raynaud’S Syndrome ◽  
Raynaud's Syndrome ◽  
Sjögren‘S Syndrome

Background: In order to analyze the prevalence of Raynaud’s syndrome in diseases such as scleroderma and Sjögren’s syndrom – a meta-analysis of published data was performed. Methods: The PubMed data base of the National Library of Medicine was used for studies dealing with Raynaud’s syndrome and scleroderma or Raynaud’s syndroem and Sjögren’s syndrom respectively. The studies found provided data sufficient to estimate the prevalence of Raynaud’s syndrome. The statistical analysis was based on methods for a fixed effects meta-analysis and finite mixture model for proportions. Results: For scleroderma a pooled prevalence of 80.9% and 95% CI (0.78, 0.83) was obtained. A mixture model analysis found four latent classes. We identified a class with a very low prevalence of 11%, weighted with 0.15. On the other hand there is a class with a very high prevalence of 96%. Analysing the association with Sjögren’s syndrome, the pooled analysis leads to a prevalence of Raynaud’s syndrome of 32%, 95% CI(26.7%, 37.7%). A mixture model finds a solution with two latent classes. Here, 38% of the studies show a prevalence of 18.8% whereas 62% observe a prevalence of 38.3%. Conclusion: There is strong variability of studies reporting the prevalence of Raynaud’s syndrome in patients suffering from scleroderma or Sjögren’s syndrome. The available data are insufficient to perform a proper quantitative analysis of the association of Raynaud’s phenomenon with scleroderma or Sjögren’s syndrome. Properly planned and reported epidemiological studies are needed in order to perform a thorough quantitative analysis of risk factors for Raynaud’s syndrome.

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