Retrobulbar Hemodynamics and Visual Field Progression in Normal Tension Glaucoma: A Long-Term Follow-Up Study

Purpose. Vascular risk factors are important factors in the pathogenesis of glaucoma. The purpose of this research was to investigate retrobulbar hemodynamics and visual field progression in patients with normal tension glaucoma (NTG).Patients and Methods. 31 eyes of 16 patients with NTG were included in a retrospective long-term follow-up study. Colour Doppler imaging was performed at baseline to determine various CDI parameters in the different retrobulbar vessels. The rate of visual field progression was determined using the Visual Field Index (VFI) progression rate per year (in %). To be included in the analysis, patients had at least 4 visual field examinations with a follow-up of at least 2 years.Results. Mean follow-up was 7.6 ± 4.1 years with an average of 10 ± 5 visual field tests. The mean MD (mean defect) at baseline was −7.61 ± 7.49 dB. The overall VFI progression was −1.14 ± 1.40% per year. A statistical significant correlation between VFI progression and the RI of the NPCA and PSV of the CRA was found.Conclusion. Long-term visual field progression may be linked to impaired retrobulbar hemodynamics in patients with NTG only to a limited degree. Interpretation of the data for an individual patient seems to be limited due to the variability of parameters.

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Long-term follow-up of visual field progression after trabeculectomy in progressive normal-tension glaucoma

Ophthalmology ◽

10.1016/s0161-6420(01)01009-0 ◽

2002 ◽

Vol 109 (4) ◽

pp. 766-770 ◽

Cited By ~ 62

Author(s):

Takashi Shigeeda ◽

Atsuo Tomidokoro ◽

Makoto Araie ◽

Nobuyuki Koseki ◽

Seiichiro Yamamoto

Keyword(s):

Visual Field ◽

Normal Tension Glaucoma ◽

Visual Field Progression ◽

Long Term Follow Up

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Long-Term Follow-Up After Successful Trabeculectomy: A Case Report of Reversal of Cupping and Recovery of Visual Field Progression

Cureus ◽

10.7759/cureus.13520 ◽

2021 ◽

Author(s):

Shunsuke Nakakura ◽

Ryo Asaoka ◽

Yoshiaki Kiuchi

Keyword(s):

Case Report ◽

Visual Field ◽

Visual Field Progression ◽

Long Term Follow Up

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Visual Subfield Progression in Glaucoma Subtypes

Journal of Ophthalmology ◽

10.1155/2018/7864219 ◽

2018 ◽

Vol 2018 ◽

pp. 1-6 ◽

Cited By ~ 3

Author(s):

Wei-Wen Su ◽

Shian-Sen Hsieh ◽

Shih-Tsung Cheng ◽

Cheng-Wen Su ◽

Wei-Chi Wu ◽

...

Keyword(s):

Visual Field ◽

Open Angle Glaucoma ◽

Demographic Data ◽

Normal Tension Glaucoma ◽

Rate Of Change ◽

Threshold Sensitivity ◽

Angle Closure ◽

Visual Field Progression

Purpose. To investigate visual field progression pattern and factors associated with progression in patients with primary open-angle glaucoma (POAG), normal-tension glaucoma (NTG), and chronic angle-closure glaucoma (CACG). Methods. The raw data of the 30-2 Humphrey Field Analyzer from glaucoma patients with definite visual field progression were processed with pointwise linear regression (PLR) analysis. The rate of change of retinal threshold sensitivity in the ten glaucoma hemifield test (GHT) zones, the upper and the lower hemifields, and the whole field was evaluated and was correlated with patients’ basic demographic data. Results. An average follow-up of 6.94 ± 2.69 years that showed the rate of change of visual field threshold sensitivity was correlated with the peak posttreatment intraocular pressure (IOP) and the long-term IOP fluctuations in all GHT zones except in the inferior arcuate area. The baseline IOP, the trough posttreatment IOP, the refractive status, and the CCT were not correlated with VF progression. Conclusion. The rate of visual field progression was correlated with the peak posttreatment IOP and the long-term IOP fluctuation but with subfield differences.

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Long-Term Clinical Course of Normal-Tension Glaucoma: 20 Years of Experience

Journal of Ophthalmology ◽

10.1155/2017/2651645 ◽

2017 ◽

Vol 2017 ◽

pp. 1-6 ◽

Cited By ~ 4

Author(s):

Sang Wook Jin ◽

Seung Yoon Noh

Keyword(s):

Visual Field ◽

Clinical Course ◽

Visual Fields ◽

Reduction Rate ◽

Normal Tension Glaucoma ◽

Mean Deviation ◽

Progression Rate ◽

Visual Field Progression ◽

The Mean

Purpose. The purpose of this study was to investigate the long-term clinical course of NTG patients who initiated intraocular pressure- (IOP-) lowering therapy.Methods. The present study included 72 normal-tension glaucoma (NTG) patients. The mean deviation (MD) was measured with visual fields. Nocturnal hypotension with weighted standard deviation (wSD) was determined by 24-hour ambulatory blood pressure monitoring. To identify risk factors for NTG progression, linear logistic regression analysis was employed.Results. The mean follow-up period was 21.2 ± 1.1 years. The mean MD progression rate was −0.28 ± 0.24 dB/year. The mean ocular perfusion pressure (OPP) was 52.1 ± 5.9 mmHg. The mean wSD was 14.5 ± 2.2. In the univariate model, disc hemorrhage (RR 7.12;P=0.004), IOP reduction rate (RR 2.12;P=0.045), and OPP (RR 1.94;P=0.027) were associated with glaucomatous visual field progression. However, in the multivariate model, the IOP reduction rate (RR 2.45;P=0.048) and OPP (RR 2.02;P=0.004) were detected to be significant factors associated with progression.Conclusions. The mean rate of visual field progression was −0.28 dB/year in NTG patients treated with medical therapy. The IOP reduction rate and OPP were associated with glaucomatous visual field progression.

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