Long-term follow-up of visual field progression after trabeculectomy in progressive normal-tension glaucoma

Ophthalmology ◽  
2002 ◽  
Vol 109 (4) ◽  
pp. 766-770 ◽  
Author(s):  
Takashi Shigeeda ◽  
Atsuo Tomidokoro ◽  
Makoto Araie ◽  
Nobuyuki Koseki ◽  
Seiichiro Yamamoto
Keyword(s):  
Visual Field ◽  
Normal Tension Glaucoma ◽  
Visual Field Progression ◽  
Long Term Follow Up

scholarly journals Retrobulbar Hemodynamics and Visual Field Progression in Normal Tension Glaucoma: A Long-Term Follow-Up Study

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
D. Kuerten ◽  
M. Fuest ◽  
E. C. Koch ◽  
A. Koutsonas ◽  
N. Plange
Keyword(s):  
Visual Field ◽  
Normal Tension Glaucoma ◽  
Doppler Imaging ◽  
Progression Rate ◽  
Visual Field Progression ◽  
Follow Up Study ◽  
Long Term Follow Up ◽  
Retrobulbar Hemodynamics

Purpose. Vascular risk factors are important factors in the pathogenesis of glaucoma. The purpose of this research was to investigate retrobulbar hemodynamics and visual field progression in patients with normal tension glaucoma (NTG).Patients and Methods. 31 eyes of 16 patients with NTG were included in a retrospective long-term follow-up study. Colour Doppler imaging was performed at baseline to determine various CDI parameters in the different retrobulbar vessels. The rate of visual field progression was determined using the Visual Field Index (VFI) progression rate per year (in %). To be included in the analysis, patients had at least 4 visual field examinations with a follow-up of at least 2 years.Results. Mean follow-up was 7.6 ± 4.1 years with an average of 10 ± 5 visual field tests. The mean MD (mean defect) at baseline was −7.61 ± 7.49 dB. The overall VFI progression was −1.14 ± 1.40% per year. A statistical significant correlation between VFI progression and the RI of the NPCA and PSV of the CRA was found.Conclusion. Long-term visual field progression may be linked to impaired retrobulbar hemodynamics in patients with NTG only to a limited degree. Interpretation of the data for an individual patient seems to be limited due to the variability of parameters.

scholarly journals Visual Subfield Progression in Glaucoma Subtypes

2018 ◽  
Vol 2018 ◽  
pp. 1-6 ◽  
Author(s):  
Wei-Wen Su ◽  
Shian-Sen Hsieh ◽  
Shih-Tsung Cheng ◽  
Cheng-Wen Su ◽  
Wei-Chi Wu ◽  
...  
Keyword(s):  
Visual Field ◽  
Open Angle Glaucoma ◽  
Demographic Data ◽  
Normal Tension Glaucoma ◽  
Rate Of Change ◽  
Threshold Sensitivity ◽  
Angle Closure ◽  
Visual Field Progression

Purpose. To investigate visual field progression pattern and factors associated with progression in patients with primary open-angle glaucoma (POAG), normal-tension glaucoma (NTG), and chronic angle-closure glaucoma (CACG). Methods. The raw data of the 30-2 Humphrey Field Analyzer from glaucoma patients with definite visual field progression were processed with pointwise linear regression (PLR) analysis. The rate of change of retinal threshold sensitivity in the ten glaucoma hemifield test (GHT) zones, the upper and the lower hemifields, and the whole field was evaluated and was correlated with patients’ basic demographic data. Results. An average follow-up of 6.94 ± 2.69 years that showed the rate of change of visual field threshold sensitivity was correlated with the peak posttreatment intraocular pressure (IOP) and the long-term IOP fluctuations in all GHT zones except in the inferior arcuate area. The baseline IOP, the trough posttreatment IOP, the refractive status, and the CCT were not correlated with VF progression. Conclusion. The rate of visual field progression was correlated with the peak posttreatment IOP and the long-term IOP fluctuation but with subfield differences.

scholarly journals Arteriovenous Passage Times and Visual Field Progression in Normal Tension Glaucoma

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Eva Charlotte Koch ◽  
Kay Oliver Arend ◽  
Marion Bienert ◽  
Andreas Remky ◽  
Niklas Plange
Keyword(s):  
Visual Field ◽  
Field Tests ◽  
Normal Tension Glaucoma ◽  
Retinal Blood Flow ◽  
Visual Field Progression ◽  
Confocal Scanning Laser Ophthalmoscope ◽  
Confocal Scanning ◽  
Confocal Scanning Laser ◽  
Passage Times

Purpose. Fluorescein angiographic studies revealed prolonged arteriovenous passage (AVP) times and increased fluorescein filling defects in normal tension glaucoma (NTG) compared to healthy controls. The purpose of this study was to correlate baseline AVP and fluorescein filling defects with visual field progression in patients with NTG.Patients and Methods. Patients with a follow-up period of at least 3 years and at least 4 visual field examinations were included in this retrospective study. Fluorescein angiography was performed at baseline using a confocal scanning laser ophthalmoscope (SLO, Rodenstock Instr.); fluorescein filling defects and AVP were measured by digital image analysis and dye dilution curves (25 Hz). Visual field progression was evaluated using regression analysis of the MD (Humphrey-Zeiss, SITA-24-2, MD progression per year (dB/year)). 72 patients with NTG were included, 44 patients in study 1 (fluorescein filling defects) and 28 patients in study 2 (AVP).Results. In study 1 (mean follow-up years, visual field tests), MD progression per year ( dB/year) was significantly correlated to the age (, ) but not to fluorescein filling defects, IOP, or MD at baseline. In study 2 (mean follow-up years, visual field tests), MD progression per year ( dB/year) was significantly correlated to AVP (, ) but not to age, IOP, or MD at baseline.Conclusion. Longer AVP times at baseline are correlated to visual field progression in NTG. Impaired retinal blood flow seems to be an important factor for glaucoma progression.

Optical Coherent Tomography Predicts Long-Term Visual Outcome of Pituitary Adenoma Surgery: New Perspectives From a 5-Year Follow-up Study

Neurosurgery ◽  
2020 ◽  
Vol 88 (1) ◽  
pp. 106-112 ◽  
Author(s):  
Young Soo Chung ◽  
Minkyun Na ◽  
Jihwan Yoo ◽  
Woohyun Kim ◽  
In-Ho Jung ◽  
...  
Keyword(s):  
Pituitary Adenoma ◽  
Visual Field ◽  
Assessment Tool ◽  
Visual Fields ◽  
Visual Field Defects ◽  
Mean Deviation ◽  
Rnfl Thickness ◽  
Long Term Follow Up

Abstract BACKGROUND Compressive optic neuropathy is the most common indication for transsphenoidal surgery for pituitary adenomas. Optical coherence tomography (OCT) is a useful visual assessment tool for predicting postoperative visual field recovery. OBJECTIVE To analyze visual parameters and their association based on long-term follow-up. METHODS Only pituitary adenoma patients with abnormal visual field defects were selected. A total of 188 eyes from 113 patients assessed by visual field index (VFI) and 262 eyes from 155 patients assessed by mean deviation (MD) were enrolled in this study. Postoperative VFI, MD, and retinal nerve fiber layer (RNFL) thickness were evaluated and followed up. After classifying the patients into normal (>5%) and thin (<5%) RNFL groups, we investigated whether preoperative RNFL could predict visual field outcomes. We also observed how RNFL changes after surgery on a long-term basis. RESULTS Both preoperative VFI and MD had a linear proportional relationship with preoperative RNFL thickness. Sustained improvement of the visual field was observed after surgery in both groups, and the degree of improvement over time in each group was similar. RNFL thickness continued to decrease until 36 mo after surgery (80.2 ± 13.3 μm to 66.6 ± 11.9 μm) while visual field continued to improve (VFI, 61.8 ± 24.5 to 84.3 ± 15.4; MD, −12.9 ± 7.3 dB to −6.3 ± 5.9 dB). CONCLUSION Patients with thin preoperative RNFL may experience visual recovery similar to those with normal preoperative RNFL; however, the probability of normalized visual fields was not comparable. RNFL thickness showed a strong correlation with preoperative visual field defect. Long-term follow-up observation revealed a discrepancy between anatomic and functional recovery.

scholarly journals Long‐term effects of trabeculectomy on visual field progression across two centres in the United Kingdom: A 10 year follow‐up

2022 ◽  
Vol 100 (S267) ◽  
Author(s):  
Yingjia Yang ◽  
Matthew Shah ◽  
Hannaa Bobat ◽  
Anastasios Sepetis ◽  
Peter Shah ◽  
...  
Keyword(s):  
United Kingdom ◽  
Visual Field ◽  
Long Term Effects ◽  
Visual Field Progression ◽  
The United Kingdom

scholarly journals Long-Term Follow-Up of Normal Tension Glaucoma Patients With TBK1 Gene Mutations in One Large Pedigree

2020 ◽  
Vol 214 ◽  
pp. 52-62
Author(s):  
Tyler S. Quist ◽  
Chris A. Johnson ◽  
Alan L. Robin ◽  
John H. Fingert
Keyword(s):  
Gene Mutations ◽  
Normal Tension Glaucoma ◽  
Large Pedigree ◽  
Long Term Follow Up ◽  
Tbk1 Gene

scholarly journals Association of Ultrapure Citicoline, Homotaurine and Vitamin E in the Management of Normotensive Glaucoma: A Case Report

2020 ◽  
Vol 11 (2) ◽  
pp. 222-228 ◽  
Author(s):  
Tommaso Verdina ◽  
Nicola Passarelli ◽  
Alessandra Carlini ◽  
Francesca Chemello ◽  
Rodolfo Mastropasqua ◽  
...  
Keyword(s):  
Vitamin E ◽  
Ganglion Cells ◽  
Neuroprotective Effect ◽  
Normal Tension Glaucoma ◽  
Caucasian Woman ◽  
Glaucoma Medication ◽  
Fiber Layer ◽  
Long Term Follow Up

Normal tension glaucoma (NTG) remains a therapeutic challenge for the ophthalmologist since there are no effective therapies as the main therapeutic target, i.e., the intraocular pressure (IOP) increase, is missed. We report on the effectiveness of two neuroprotective molecules (ultrapure citicoline plus homotaurine), in combination with a topical hypotensive approach, in the management of NTG in a long-term follow-up (30 months). A 38-year-old Caucasian woman with no significant medical history and a diagnosis of NTG, after an extensive 30-month treatment with oral dietary supplement containing ultrapure citicoline 500 mg, homotaurine 50 mg and vitamin E once per day and topical glaucoma medication (brimonidine + brinzolamide drops twice per day), presented a significantly improved automated 24-2 visual field with a controlled tonometric measurement associated with a stabilization of retinal fiber layer and ganglion cells at OCT examination with patient satisfaction. This finding suggests that ultrapure citicoline together with homotaurine and vitamin E, through a synergistic neuroprotective effect, could be a promising approach in the management of NTG.

Visual field deficits following anterior temporal lobectomy: Long-term follow-up and prognostic implications

Epilepsia ◽  
2010 ◽  
Vol 51 (6) ◽  
pp. 1018-1023 ◽  
Author(s):  
Debbie Yam ◽  
David Nicolle ◽  
David A. Steven ◽  
Donald Lee ◽  
Tiiu Hess ◽  
...  
Keyword(s):  
Visual Field ◽  
Temporal Lobectomy ◽  
Anterior Temporal Lobectomy ◽  
Visual Field Deficits ◽  
Long Term Follow Up ◽  
Prognostic Implications

scholarly journals Impact of intraocular pressure fluctuations on progression of normal tension glaucoma

2021 ◽  
Vol 14 (10) ◽  
pp. 1553-1559
Author(s):  
Susanne Hopf ◽  
◽  
Irene Schmidtmann ◽  
Norbert Pfeiffer ◽  
Esther Maria Hoffmann ◽  
...  
Keyword(s):  
Intraocular Pressure ◽  
Visual Field ◽  
Optic Disc ◽  
Cox Regression ◽  
Group Analysis ◽  
Normal Tension Glaucoma ◽  
Short And Long Term ◽  
The Impact

AIM: To investigate short- and long-term intraocular pressure (IOP) fluctuations and further ocular and demographic parameters as predictors for normal tension glaucoma (NTG) progression. METHODS: This retrospective, longitudinal cohort study included 137 eyes of 75 patients with NTG, defined by glaucomatous optic disc or visual field defect with normal IOP (<21 mm Hg), independently from therapy regimen. IOP fluctuation, mean, and maximum were inspected with a mean follow-up of 38mo [standard deviation (SD) 18mo]. Inclusion criteria were the performance of minimum two 48-hour profiles including perimetry, Heidelberg retina tomograph (HRT) imaging, and optic disc photographs. The impact of IOP parameters, myopia, sex, cup-to-disc-ratio, and visual field results on progression of NTG were analyzed using Cox regression models. A sub-group analysis with results from optical coherence tomography (OCT) was performed. RESULTS: IOP fluctuations, average, and maximum were not risk factors for progression in NTG patients, although maximum IOP at the initial IOP profile was higher in eyes with progression than in eyes without progression (P=0.054). The 46/137 (33.5%) eyes progressed over the follow-up period. Overall progression (at least three progression confirmations) occurred in 28/137 eyes (20.4%). Most progressions were detected by perimetry (36/46). Long-term IOP mean over all pressure profiles was 12.8 mm Hg (SD 1.3 mm Hg); IOP fluctuation was 1.4 mm Hg (SD 0.8 mm Hg). The progression-free five-year rate was 58.2% (SD 6.5%). CONCLUSION: Short- and long-term IOP fluctuations do not result in progression of NTG. As functional changes are most likely to happen, NTG should be monitored with visual field testing more often than with other devices.

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