Performance of Three Multipurpose Disinfecting Solutions with a Silicone Hydrogel Contact Lens

Purpose. To evaluate the clinical performance of a silicone hydrogel (Si-Hy) soft contact lens (CL) in combination with three different multipurpose disinfecting solutions (MPDSs).Methods. This was a prospective, randomized, single-masked, crossover, and comparative study in which 31 habitual soft CL wearers were randomly assigned to one of the three MPDSs (Synergi, COMPLETE RevitaLens, and OPTI-FREE PureMoist) for 1 month with a 1-week wash-out period between each exposure. All subjects were successfully refitted with a Si-Hy CL (Biofinity). Subjects were then scheduled for follow-up visits after 1 month of lens wear, being evaluated at 2 and 8 hours after lens insertion. Visual Analogue Scales (VAS) were used to gauge comfort rating.Results. The tarsal conjunctiva showed a significantly different degree of lid redness between the MPDSs at the 2-hour visit (P<0.05, Kruskal-Wallis test), being lower for COMPLETE RevitaLens compared to the other two MPDSs (Mann-WhitneyUtest). Furthermore, a significantly different degree of lid roughness at the 8-hour visit was seen (P<0.05, Kruskal-Wallis test), being higher for Synergi (Mann-WhitneyUtest). The subjective comfort was similar with the three MPDSs.Conclusion.Tarsal conjunctival response should be also considered in the context of the clinical performance of MPDs at the ocular surface.

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Changes in Tear Cytokines Following a Short Period of Daily and Overnight Silicone Hydrogel Lens Wear

Journal of Contact lens Research and Science ◽

10.22374/jclrs.v1i1.10 ◽

2017 ◽

Vol 1 (1) ◽

pp. 3-11 ◽

Cited By ~ 3

Author(s):

Kim Duong ◽

Cecilia Chao ◽

Mark Willcox ◽

Kathryn Richdale

Keyword(s):

Contact Lens ◽

Diurnal Fluctuation ◽

Soft Contact ◽

Contact Lens Wear ◽

Silicone Hydrogel ◽

Soft Contact Lens ◽

Inflammatory Status ◽

Tnf Α ◽

Short Period ◽

Lens Wear

Background and Objective: To investigate changes in ocular surface inflammatory markers after daily and overnight silicone hydrogel contact lens wear in healthy wearers. Material and Methods: Twenty-six experienced soft contact lens subjects were evaluated at baseline, after 1-day of silicone hydrogel lens wear, and after 1-night of wear. Basal tears were collected at each visit and tear cytokine concentrations were quantified using multiplex [interleukin (IL)-1β, IL-6, IL-10, IL-12(p70), IL-17A and tumor necrosis factor (TNF)-α] or ELISA (IL-8) kits. A historical control group of 27 non-contact lens wearers was used to compare absolute concentrations and diurnal variations in tear cytokine concentrations. Changes in cytokine concentrations were analyzed using linear mixed models. Linear regression with bootstrapping was used to assess whether changes in IL-1β concentrations were associated with changes in other cytokines. Results: IL-8 concentrations decreased after 1 day of silicone hydrogel contact lens wear and returned to baseline levels the next morning (p=0.04). This same diurnal fluctuation was seen in non-contact lens wearers (p=0.03). With daily contact lens wear, there was a significant positive correlation between the changes in IL-1β and IL-8, TNF-α, IL-10 and IL-12(p70) (all p<0.03). With overnight contact lens wear, there were significant positive correlations between the changes in IL-1β and IL-6, IL-17A and TNF-α (all p<0.01). Conclusion: A short period of daily and overnight silicone hydrogel lens wear does not significantly alter the inflammatory status in adapted soft contact lens wearers.

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