Assessment of Macular Parameter Changes in Patients with Keratoconus Using Optical Coherence Tomography

Keratoconus is typically diagnosed through changes at the anterior ocular surface. However, we wished to assess if macular parameter changes might also occur in these patients. We assessed posterior changes through the use of optical coherence tomography and compared to a nonkeratoconus patient group. All subjects underwent clinical examination including macular thickness measurements. The generalized estimation equation model was used to estimate the means and compare the differences in various measurements between keratoconus and nonkeratoconus patients. A total of 129 keratoconus eyes of 67 cases and 174 nonkeratoconus eyes of 87 controls were analysed. Keratoconus individuals presented with a significantly greater mean retinal thickness in the central fovea, inner, and outer macula compared to the nonkeratoconus group (p<0.05). In addition, individuals presenting with the early signs of keratoconus had significantly greater inner and outer macular volume compared to the nonkeratoconus group (p<0.05). This study indicates the retina appears to thicken at the fovea and macula and had increased macular volume in keratoconus individuals compared to nonkeratoconus individuals. Thus we posit that structural retinal changes exist in keratoconus eyes that are additional to those typically seen in the anterior segment.

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Non-malignant conjunctival epithelial masses with ocular surface squamous neoplasia-like optical coherence tomography features

International Ophthalmology ◽

10.1007/s10792-021-01743-y ◽

2021 ◽

Author(s):

Ágnes Füst ◽

Jeannette Tóth ◽

László Imre ◽

Zoltán Zsolt Nagy

Keyword(s):

Optical Coherence Tomography ◽

Ocular Surface ◽

Anterior Segment ◽

Histological Diagnosis ◽

Optical Coherence ◽

Ocular Surface Squamous Neoplasia ◽

Ocular Coherence Tomography ◽

Maximal Thickness ◽

Epithelial Lesions ◽

Mass Lesions

Abstract Purpose To observe and describe the anterior segment optical coherence tomography features of limbally localised non-malignant epithelial mass lesions Methods Thirteen patients (age: 66.9 ± 16.3 years) with conjunctival mass suggesting ocular surface squamous neoplasia with biomicroscopic examination were imaged using anterior segment ocular coherence tomography (anterior segment optical coherence tomography)/Cirrus HD-OCT, Model 4000, Carl Zeiss Meditec, Inc., Dublin, CA, and Spectralis HRA + OCT system, Heidelberg Engineering, Vista, CA/. Cases with ocular surface squamous neoplasia-like anterior segment optical coherence tomography (hyperreflective, thickened epithelium and an abrupt transition from normal to abnormal) were included in the study. Maximal thickness of the epithelium was measured. Histological diagnosis was gained from an excisional or incisional biopsy or impression cytology specimens. Results In six patients (age: 68.5 ± 15.4 years) with ocular surface squamous neoplasia-like anterior segment optical coherence tomography features, the histological diagnosis was other than ocular surface squamous neoplasia (papilloma, parakeratosis and a keratotic plaque with mild dysplasia), and ocular surface squamous neoplasia in seven cases (age: 65.6 ± 18.0 years). The maximal epithelial thickness was between 250 and 859 µm in non-ocular surface squamous neoplasia cases and between 252 and 596 µm in ocular surface squamous neoplasia cases. Conclusion Non-malignant epithelial lesions can mimic ocular surface squamous neoplasia on anterior segment optical coherence tomography.

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Quality and Reproducibility of Retinal Thickness Measurements in Two Spectral-Domain Optical Coherence Tomography Machines

Investigative Opthalmology & Visual Science ◽

10.1167/iovs.10-6612 ◽

2011 ◽

Vol 52 (9) ◽

pp. 6925 ◽

Cited By ~ 26

Author(s):

Ilse Krebs ◽

Eva Smretschnig ◽

Sarah Moussa ◽

Werner Brannath ◽

Irene Womastek ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Retinal Thickness ◽

Spectral Domain ◽

Optical Coherence ◽

Thickness Measurements

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Comparison of Central Corneal Thickness Measurements by Visante Anterior Segment Optical Coherence Tomography With Ultrasound Pachymetry

American Journal of Ophthalmology ◽

10.1016/j.ajo.2007.01.050 ◽

2007 ◽

Vol 143 (6) ◽

pp. 1047-1049 ◽

Cited By ~ 73

Author(s):

Paul S. Zhao ◽

Tien Yin Wong ◽

Wan-Ling Wong ◽

Seang-Mei Saw ◽

Tin Aung

Keyword(s):

Optical Coherence Tomography ◽

Central Corneal Thickness ◽

Corneal Thickness ◽

Anterior Segment ◽

Optical Coherence ◽

Ultrasound Pachymetry ◽

Thickness Measurements

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REPEATABILITY AND REPRODUCIBILITY OF RETINAL THICKNESS MEASUREMENTS WITH SPECTRAL-DOMAIN OPTICAL COHERENCE TOMOGRAPHY USING DIFFERENT SCAN PARAMETERS

Retina ◽

10.1097/iae.0b013e31822f5660 ◽

2012 ◽

Vol 32 (5) ◽

pp. 1007-1012 ◽

Cited By ~ 5

Author(s):

Andrea Giani ◽

Antonio Peroglio Deiro ◽

Giovanni Staurenghi

Keyword(s):

Optical Coherence Tomography ◽

Retinal Thickness ◽

Spectral Domain ◽

Optical Coherence ◽

Repeatability And Reproducibility ◽

Thickness Measurements

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Anterior segment optical coherence tomography and ultrasound biomicroscopy for measuring thickness of corneal and bulbar conjunctival tumours

British Journal of Ophthalmology ◽

10.1136/bjophthalmol-2018-312337 ◽

2021 ◽

pp. bjophthalmol-2018-312337

Author(s):

Noémie Lauwers ◽

Katleen Janssens ◽

Michelle Mertens ◽

Danny Mathysen ◽

Martin Lammens ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Gold Standard ◽

Imaging Techniques ◽

Anterior Segment ◽

Ultrasound Biomicroscopy ◽

Thickness Measurement ◽

Histopathological Analysis ◽

Optical Coherence ◽

Tumour Thickness ◽

Thickness Measurements

Background/ObjectiveAnterior segment optical coherence tomography (AS-OCT) and ultrasound biomicroscopy (UBM) are two non-invasive imaging techniques used for the measurement of tumour thickness in corneal and bulbar conjunctival tumours. Histopathology (HP), however, remains the gold standard for the measurement of tumour thickness. The aim of this study was to determine whether AS-OCT and UBM are as accurate as HP for measuring tumour thickness.MethodsForty-two corneal and bulbar conjunctival tumours were imaged using AS-OCT and UBM. Images were assessed and tumour thickness was measured. Eleven patients subsequently underwent surgical excision. All specimens were measured during histopathological analysis. The correlation of the thickness measurement on HP to AS-OCT and UBM was then statistically analysed. In cases where the tumour was not excised, thickness measurement comparisons between AS-OCT and UBM were analysed.ResultsAS-OCT and UBM measurements of tumour thickness were found to be significantly positively correlated (p=<0.001), as were UBM and HP thickness measurements (p=0.031). HP and AS-OCT measurements, however, only showed a mild but non-significant positive correlation.ConclusionBoth AS-OCT and UBM are useful techniques to image and measure the thickness of corneal and conjunctival bulbar tumours. While AS-OCT provides better details than UBM, it was more limited in visualising the posterior boundary of the tumour, particularly in malignant tumours. While thickness measurements of both methodologies were correlated, neither should yet be considered as replacements to the gold standard of HP.

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