scholarly journals Malignant Transformation Rate in Patients Presenting Oral Epithelial Dysplasia: Systematic Review and Meta-Analysis

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Jaffer A. Shariff ◽  
Athanasios I. Zavras
Keyword(s):  
Systematic Review ◽  
Malignant Transformation ◽  
Observational Studies ◽  
Meta Analysis ◽  
Epithelial Dysplasia ◽  
High Rate ◽  
Transformation Rate ◽  
Oral Epithelial Dysplasia ◽  
Observational Cohort ◽  
Oral Epithelial

Objective. To perform a systematic review and meta-analysis on studies that assess malignant transformation rates (MTR) of oral epithelial dysplasia. Materials and Methods. This review was planned and conducted in accordance with the meta-analysis of observational studies in epidemiology (MOOSE) guidelines. PubMed, EMBASE, Google Scholar, and Cochrane databases were screened to identify observational studies. Quality assessments were completed by two reviewers independently using the Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies. Pooled-malignant transformation rate (MTR) in person years, subgroup, sensitivity, and publication bias analysis were calculated using STATA 13.0 and Comprehensive Meta-Analysis software. Results. Sixteen observational cohort studies were identified with a total of 3708 participants from Asia, North America, and Europe. Analysis showed a MTR of 10.5% (pooled-MTR: 10.5, 95% CI: 3.7 to 17.3; fixed effect model, I2=0.0%; Q-value = 2.389; p>0.05) among patients with histologically confirmed oral epithelia dysplasia undergoing long-term follow-up. Higher MTR in person year were seen among the sever dysplastic cases (pooled-MTR: 14.4%, 95% CI: 5.3% to 23.5%), studies published in Europe (pooled-MTR: 12.6%, 95% CI: 8.0% to 24.3%), and retrospective studies (pooled-MTR: 11.0%, 95% CI: 2.2% to 19.9%). Conclusion. These studies show that oral epithelial dysplasia has a significant high rate of transformation to cancer.

Oral Epithelial Dysplasia Grading Systems: A Systematic Review & Meta-Analysis

2022 ◽  
pp. 106689692110701
Author(s):  
Zaid H. Khoury ◽  
Mohamed Sultan ◽  
Ahmed S. Sultan
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Observer Agreement ◽  
Epithelial Dysplasia ◽  
Primary Research ◽  
Level Of Evidence ◽  
Minimal Impact ◽  
Oral Epithelial Dysplasia ◽  
Grading Systems ◽  
Oral Epithelial

This systematic review and meta-analysis aims to provide a robust qualitative and quantitative analysis of the different systems used to assess the grade of oral epithelial dysplasia (OED). This study was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-analyzes (PRISMA) statement. Six electronic databases were searched for primary research published over the past four decades. Overall quality and level of evidence were based on the Johns Hopkins Research Evidence Appraisal Tool, while evidence of heterogeneity was determined by the Q-statistic and I^2 statistic. Evidence of publication bias was determined using Egger's regression and the Rank correlation tests. A total of 170 records were identified. Only 9 primary research articles were included in the qualitative systematic review. Four studies (4/9) were included in the final quantitative meta-analysis. The grading systems analyzed included the WHO, binary, Ljubljana, Smith and Pindborg, Brothwell, and the oral intraepithelial neoplasia. The results demonstrate the binary system to be superior to the WHO system in grading OED, by providing better inter-observer agreement, however, the substantial error among the inter-observer κ values analyzed indicates the significance of this finding to be of minimal impact. Lack of reliable reproducibility of the grading systems and lack of common effect size (heterogeneity analysis) were noted.

Prevalence of human papillomavirus in oral epithelial dysplasia: Systematic review and meta‐analysis

Head & Neck ◽  
2020 ◽  
Vol 42 (10) ◽  
pp. 2975-2984
Author(s):  
Cecilie Dovey de la Cour ◽  
Cecilie Dyg Sperling ◽  
Federica Belmonte ◽  
Stina Syrjänen ◽  
Freija Verdoodt ◽  
...  
Keyword(s):  
Systematic Review ◽  
Human Papillomavirus ◽  
Meta Analysis ◽  
Epithelial Dysplasia ◽  
Oral Epithelial Dysplasia ◽  
Oral Epithelial

scholarly journals Elucidating drivers of oral epithelial dysplasia formation and malignant transformation to cancer using RNAseq

Oncotarget ◽  
2015 ◽  
Vol 6 (37) ◽  
pp. 40186-40201 ◽  
Author(s):  
Caroline Conway ◽  
Jennifer L. Graham ◽  
Preetha Chengot ◽  
Catherine Daly ◽  
Rebecca Chalkley ◽  
...  
Keyword(s):  
Malignant Transformation ◽  
Epithelial Dysplasia ◽  
Oral Epithelial Dysplasia ◽  
Oral Epithelial

The clinical determinants of malignant transformation in oral epithelial dysplasia

Oral Oncology ◽  
2012 ◽  
Vol 48 (10) ◽  
pp. 969-976 ◽  
Author(s):  
M.W. Ho ◽  
J.M. Risk ◽  
J.A. Woolgar ◽  
E.A. Field ◽  
J.K. Field ◽  
...  
Keyword(s):  
Malignant Transformation ◽  
Epithelial Dysplasia ◽  
Oral Epithelial Dysplasia ◽  
Oral Epithelial

scholarly journals Loss of FANCD2 and related proteins may predict malignant transformation in oral epithelial dysplasia

2020 ◽  
Author(s):  
Michael W Ho ◽  
Mark Ryan ◽  
Juhi Gupta ◽  
Asterios Triantafyllou ◽  
Janet Risk ◽  
...  
Keyword(s):  
Malignant Transformation ◽  
Tissue Sample ◽  
Good Evidence ◽  
Epithelial Dysplasia ◽  
Clinicopathological Parameters ◽  
Post Translational Modification ◽  
Oral Epithelial Dysplasia ◽  
Damage Sensing ◽  
Related Proteins ◽  
Oral Epithelial

Abstract Background: Predicting malignant transformation in oral epithelial dysplasia(OED) is a clinical challenge. The higher rate of malignant transformation in non-smokers supports an endogenous aetiology. Loss of FANCD2 and associated proteins could lead to genomic instability and oncogenesis. Patients & Methods: Longitudinal archival samples from 40 individuals with OED from time of diagnosis to the most recent review in 23 stable OED; or until excision of the SCC in 17 unstable OED undergoing malignant transformation. Histopathological reassessment, immunohistochemistry for FANCD2 and Western blotting for phosphorylation/monubiquitination status of ATR, CHK1, FANCD2 and FANCG were undertaken on each tissue sample. Results: Decreased expression of FANCD2 was observed in the diagnostic biopsy of OED lesions which later underwent malignant transformation. Combining the FANCD2 expression scores with histological grading more accurately predicted malignant transformation (p=0.005) than histology alone and correctly predicted malignant transformation in 10/17 initial biopsies. Significantly reduced expression of total FANCD2, pFANCD2, pATR, pCHK-1 and pFANCG were observed in unstable OED. Discussion: There is good evidence that defects in the DNA damage sensing-signalling-repair cascade are associated with malignant transformation in OED. Loss of post-translational modification in FANCD2 and related proteins, was more predictive of malignant transformation when compared to clinicopathological parameters.

scholarly journals Loss of FANCD2 and related proteins may predict malignant transformation in oral epithelial dysplasia

2020 ◽  
Author(s):  
Michael W Ho ◽  
Mark Ryan ◽  
Juhi Gupta ◽  
Asterios Triantafyllou ◽  
Janet Risk ◽  
...  
Keyword(s):  
Malignant Transformation ◽  
Tissue Sample ◽  
Good Evidence ◽  
Epithelial Dysplasia ◽  
Clinicopathological Parameters ◽  
Post Translational Modification ◽  
Oral Epithelial Dysplasia ◽  
Damage Sensing ◽  
Related Proteins ◽  
Oral Epithelial

Abstract Background: Predicting malignant transformation in oral epithelial dysplasia(OED) is a clinical challenge. The higher rate of malignant transformation in non-smokers supports an endogenous aetiology. Loss of FANCD2 and associated proteins could lead to genomic instability and oncogenesis.Methods: Longitudinal archival samples from 40 individuals with OED from time of diagnosis to the most recent review in 23 stable OED; or until excision of the SCC in 17 unstable OED undergoing malignant transformation. Histopathological reassessment, immunohistochemistry for FANCD2 and Western blotting for phosphorylation/monubiquitination status of ATR, CHK1, FANCD2 and FANCG were undertaken on each tissue sample.Results: Decreased expression of FANCD2 was observed in the diagnostic biopsy of OED lesions which later underwent malignant transformation. Combining the FANCD2 expression scores with histological grading more accurately predicted malignant transformation (p=0.005) than histology alone and correctly predicted malignant transformation in 10/17 initial biopsies. Significantly reduced expression of total FANCD2, pFANCD2, pATR, pCHK-1 and pFANCG were observed in unstable OED.Discussion: There is good evidence that defects in the DNA damage sensing-signalling-repair cascade are associated with malignant transformation in OED. Loss of post-translational modification in FANCD2 and related proteins, was more predictive of malignant transformation when compared to clinicopathological parameters.

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