scholarly journals Relationship between Retinal Nerve Fiber Layer Thickness and Hemoglobin Present in the Optic Nerve Head in Glaucoma

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Marta Gonzalez-Hernandez ◽  
Jose Sigut Saavedra ◽  
Manuel Gonzalez de la Rosa
Keyword(s):  
Optic Nerve ◽  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Optic Nerve Head ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Nerve Fiber Layer Thickness ◽  
Rnfl Thickness ◽  
Spectralis Oct ◽  
Retinal Nerve Fiber

Purpose. To observe the relationship between topographic hemoglobin levels in the optic nerve head (ONH), the rim thickness (BMO-MRW), and retinal nerve fiber layer (RNFL) thickness. Methods. 96 normal eyes and 82 glaucomas were examined using TOP strategy (Octopus 300 perimeter), SPECTRALIS OCT, and Laguna ONhE program which estimates hemoglobin from conventional color photographs (Horus Scope DEC 200 fundus camera). Results. The correlation between Laguna ONhE glaucoma discriminant function (GDF) and SPECTRALIS BMO-MRW was R=0.81 (P<0.0001), similar to that between the BMO-MRW and BMO-RNFL thicknesses (R=0.85, P<0.0001) (P=0.227 between both R values). GDF correlated well with RNFL thicknesses in the 360 degrees around the nerve, similar to mean perimetric sensitivity (MS) and BMO-MRW. The amount of hemoglobin in the nasal and temporal sectors showed low correlation with superior and inferior RNFL thicknesses. The superotemporal and inferotemporal sectors located on the vertical diameter of the disk showed good intercorrelation but without a clear RNFL topographic relationship. Conclusion. GDF showed high correlation with RNFL thickness. Except in the nasal and temporal sectors, ONH hemoglobin correlated well with RNFL thickness.

Effect of intraocular pressure lowering on the capillary density of optic nerve head and retinal nerve fiber layer in patients with glaucoma

2020 ◽  
pp. 112067212096723
Author(s):  
Alessandro de Paula ◽  
Andrea Perdicchi ◽  
Federico Di Tizio ◽  
Serena Fragiotta ◽  
Gianluca Scuderi
Keyword(s):  
Optic Nerve ◽  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Optic Nerve Head ◽  
Capillary Density ◽  
Control Group ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Rnfl Thickness ◽  
Retinal Nerve Fiber

Purpose: To evaluate the effect of IOP lowering on the capillary density of optic nerve head and retinal nerve fiber layer in patients with primary open angle glaucoma. Methods: Twenty eyes of 14 glaucomatous patients and 15 eyes of nine normal patients were enrolled. The most appropriate hypotonic treatment was applied to every patient. A HD Angio Disc 4.5 scan (Avanti-AngioVue) was performed at baseline and after a month in the glaucomatous eyes. The following parameters were analyzed: Radial Papillary Capillaries (RPC) density, inside disc, peripapillary, superior-hemi, inferior-hemi, quadrants, and peripapillary, hemi-superior, hemi-inferior, and quadrants RNFL thickness. Optic nerve head analysis was also evaluated. In addition, the RPC density and the RNFL were assessed in the eight sectors provided by the software. Results: The RPC density did not significantly change after IOP reduction ( p > 0.05). The inferior-temporal ( p = 0.005) and inferior-nasal sectors ( p < 0.001) showed a greater capillary density than the respective superior sectors in healthy eyes. In contrast in the glaucomatous eyes, the superior-nasal exhibited greater capillary density with respect to the inferior-nasal sectors. The aggregate RPC density of the inferior sectors was greater than the superior ones in the control group ( p < 0.001). An improvement of the average disc area ( p = 0.01) and the average cup volume ( p = 0.059) were also observed along with increased RNFL thickness at different locations (all, p < 0.05) after IOP lowering therapy was initiated. Conclusion: The glaucomatous eyes presented rarefaction of the radial papillary capillaries density in the inferior sectors, but no significant changes in the density after IOP-lowering medications.

scholarly journals The influence of corneal astigmatism on retinal nerve fiber layer thickness and optic nerve head parameter measurements by optical coherence tomography

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
S M M S Ahmed ◽  
N H Abdallah ◽  
L S Eliwa ◽  
A M Bayomy
Keyword(s):  
Optic Nerve ◽  
Nerve Fiber ◽  
Layer Thickness ◽  
Retinal Nerve Fiber Layer ◽  
Optic Nerve Head ◽  
Corneal Astigmatism ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Nerve Fiber Layer Thickness ◽  
Retinal Nerve Fiber

Abstract Background Astigmatism is a worldwide common ocular disorder. Total astigmatism is mainly driven by corneal astigmatism (CA), which occurs due to an irregular shape of the cornea. In eyes with astigmatism, retinal images can be distorted, and the image size could vary according to the axis of astigmatism assessed with computer-based methodology in astigmatic eyes. Objective to evaluate the influence of corneal astigmatism on the RNFL thickness and ONH parameters obtained by spectral-domain OCT. Patients and Methods 40 patient chosen from outpatient ophthalmology of Ain Shams University Hospitals and Om El¬_Massrein General Hospital and classified in two groups, the study group (high astigmatic patients ≥ 3 diopter) and control group (normal astigmatism&lt; 3 diopter) with no significant change in the age and sex. All cases were free of any ocular diseases with no past history of medical importance (DM, HTN or any neurological diseases), all this cases never had any previous refractive surgery or any retinal lesion. Results In this study all cases had average IOP &gt; 21 mmhg, and randomly selected from the outpatient clinic. The study group had thinner retinal nerve fiber layer in temporal quadrant and larger disc area than the control group. These study support the concept that corneal astigmatism has an effect on retinal nerve fiber layer thickness and optic nerve head parameters. Conclusion In our study, we compare between the OCT pattern of retinal nerve fiber layer thickness (total, superior, nasal and inferior quadrants) and the optic nerve head parameters (cup area, disc area, vertical and horizontal C/D ratio) in the high astigmatic patients (≥ 3 diopter) and normal astigmatism &lt; 3 diopter.

scholarly journals Evaluation of the optic nerve head and peripapillary retinal nerve fiber
layer thickness in patients receiving Electro-Convulsive Therapy

2017 ◽  
Vol 4 (12) ◽  
pp. 1885-1897 ◽  
Author(s):  
Kourosh Shahraki ◽  
Alireza Khosravi ◽  
Shiva Kaffashipour ◽  
Kianoush Shahraki ◽  
Masoud Sadeghi
Keyword(s):  
Optic Nerve ◽  
Nerve Fiber ◽  
Layer Thickness ◽  
Retinal Nerve Fiber Layer ◽  
Optic Nerve Head ◽  
Normal Range ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Nerve Fiber Layer Thickness ◽  
Retinal Nerve Fiber

Background: Electroconvulsive therapy (ECT) is a method commonly used in the treatment of psychiatric disorders. As ocular side effects from OCT are less studied and discussed, the aim of this study was to evaluate the profile of the peripapillary retinal nerve fiber layer thickness in patients receiving ECT. Method: This study was performed on 30 patients who had indication for ECT. After recording demographic data, retinal nerve fiber layer thickness was measured by using spectral domain optical coherence tomography (Heidelberg Engineering, Heidelberg, Germany) of optic nerve head and peripapillary retinal nerve fiber layer. Results: Our results showed that for most of the studied variables, the normal range was observed in less than 85% of patients receiving ECT. Variables which were outside the normal range were: cup disk (C/D) ratio (right and left eyes were 50% and 46.7%, respectively), vertical C/D ratio (right and left eyes were 53.3% and 46.7%, respectively), and cup volume (right and left eyes were 53.3% and 33.3%, respectively). Conclusion: This study showed that a high percentage of patients receiving ECT had changes in the optic nerve head while intra-ocular pressure in these patients was normal. It is warranted for examiners to pay attention to diagnosis of normal tension glaucoma in patients receiving ECT.

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