scholarly journals Bone Regeneration Effect of Hyperbaric Oxygen Therapy Duration on Calvarial Defects in Irradiated Rats

2019 ◽  
Vol 2019 ◽  
pp. 1-9 ◽  
Author(s):  
Kyeong-Mee Park ◽  
Changdae Kim ◽  
Wonse Park ◽  
Young-Bum Park ◽  
Moon-Kyu Chung ◽  
...  

Objective. In this study, we evaluated changes in bone remodeling in an irradiated rat calvarial defect model according to duration of hyperbaric oxygen therapy. Materials and Methods. The 28 rats were divided into four groups. Radiation of 12 Gy was applied to the skull, and 5-mm critical size defects were formed on both sides of the skull. Bone grafts were applied to one side of formed defects. From the day after surgery, HBO was applied for 0, 1, and 3 weeks. At 6 weeks after bone graft, experimental sites were removed and analyzed for radiography, histology, and histomorphometry. Results. Micro-CT analysis showed a significant increase in new bone volume in the HBO-3 group, with or without bone graft. When bone grafting was performed, BV, BS, and BS/TV all significantly increased. Histomorphometric analysis showed significant increases in %NBA and %BVN in the HBO-1 and HBO-3 groups, regardless of bone graft. Conclusion. Hyperbaric oxygen therapy was effective for bone regeneration with only 1 week of treatment.

2019 ◽  
Vol 49 (1) ◽  
pp. 2 ◽  
Author(s):  
Heesuk An ◽  
Jung-Tae Lee ◽  
Seo-Eun Oh ◽  
Kyeong-mee Park ◽  
Kyung-Seok Hu ◽  
...  

e-CliniC ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 550
Author(s):  
Nidia Limarga ◽  
Mendy Hatibie ◽  
Maximillian Ch. Oley

Abstract: Gnatoschizis is a congenital disorder due to complex causes involving many genetic and environmental factors. The shape and complexity of the cleft varies greatly, which will determine the final outcome of the reconstruction. The management involves a multidisciplinary approach including orthodontics, prosthodontics, as well as speech and psychological therapist. Bone grafting materials such as iliac crest (corticocancellous autogenous), bone morphogenetic proteins and recombinant human proteins have shown good long-term results. An additional method that is considered effective in accelerating bone growth is the administration of hyperbaric oxygen therapy (HBOT) which has been reported to increase the accumulation of minerals needed for osteogenesis, such as calcium, magnesium, and phosphorous. We reported a case of a 14-year-old girl with gnatoschizis who underwent an alveolar bone graft surgery and one day after the operation was immediately followed by administration of (HBOT) to improve the bone healing process. cleft location. Autogenous iliac bone graft was used for closure of the bony defect at the site of the cleft. Follow up at day-14 showed a satisfying result. In conclusion, in this patient continuity of upper dental arch was achieved as well as optimal alar basis, no fistula, stabile upper dental arch for orthodontic treatment, and ideal alveolar morphology that supported the ultimate goal of cleft palate treatment - improvement of quality of life.Keywords: gnatoschizis; alveolar bone graft; hyperbaric oxygen therapy  Abstrak: Gnatoschizis merupakan kelainan kongenital dengan penyebab kompleks yang meli-batkan banyak faktor genetik dan lingkungan. Bentuk dan kompleksitas sumbing sangat bervariasi, yang akan menentukan hasil akhir rekonstruksi. Tatalaksananya melibatkan pendekatan multi-disiplin termasuk ortodontik, prostodontik, serta terapi wicara dan psikologis. Bahan pencang-kokan tulang seperti krista iliaka (corticocancellous autogenous), protein morfogenetik tulang dan protein manusia rekombinan telah menunjukkan hasil jangka panjang yang baik. Salah satu metode tambahan yang dianggap efektif mempercepat pertumbuhan tulang ialah pemberian terapi oksigen hiperbarik (TOHB) yang telah dilaporkan meningkatkan akumulasi mineral yang dibutuh-kan untuk osteogenesis, seperti kalsium, magnesium, dan fosfor. Kami melaporkan kasus seorang anak perempuan berusia 14 tahun dengan gnatoschizis yang menjalani operasi cangkok tulang alveolar dan satu hari setelah operasi langsung dilanjutkan pemberian TOHB untuk meningkatkan proses penyembuhan tulang. Cangkok tulang iliaka autogenous digunakan untuk penutupan defek tulang di lokasi sumbing. Follow up pada hari ke 14 di poliklinik dengan pemeriksaan fisik pada defek lokasi sumbing mendapatkan hasil yang memuaskan. Simpulan laporan kasus ialah pada pasien ini diperoleh kontinuitas lengkung rahang atas, basis alar yang optimal, fistula dihilangkan, segmen rahang atas yang stabil untuk perawatan ortodontik, dan morfologi alveolar yang ideal yang menyokong tujuan akhir tatalaksana sumbing yaitu perbaikan kualitas hidup.Kata kunci: gnatoschizis; cangkok tulang alveolar; terapi oksigen hiperbarik


Oral Diseases ◽  
2019 ◽  
Vol 25 (3) ◽  
pp. 822-830 ◽  
Author(s):  
Kyeong‐Mee Park ◽  
Kyung‐Seok Hu ◽  
Hyunmin Choi ◽  
Seo‐Eun Oh ◽  
Hyeong‐Il Kim ◽  
...  

2016 ◽  
Vol 10 (3) ◽  
pp. 409-417
Author(s):  
Gabriel Pires Pastore ◽  
Ivan Solani Martins ◽  
Douglas Rangel Goulart ◽  
Alexandre Javaroni Prati ◽  
Márcio de Moraes ◽  
...  

2018 ◽  
Vol 59 (6) ◽  
pp. 574-580 ◽  
Author(s):  
Pâmella Coelho Dias ◽  
Pedro Henrique Justino Oliveira Limirio ◽  
Camila Rodrigues Borges Linhares ◽  
Mariana Lobo Bergamini ◽  
Flaviana Soares Rocha ◽  
...  

2013 ◽  
Vol 17 (4) ◽  
pp. 311-314 ◽  
Author(s):  
Maiolino Thomaz Fonseca Oliveira ◽  
Flaviana Soares Rocha ◽  
Luiz Fernando Barbosa de Paulo ◽  
Átila Roberto Rodrigues ◽  
Darceny Zanetta-Barbosa

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