scholarly journals Prophylaxis of Upper Airway Infections in a Patient with Partial IgA Deficiency: Concurrent Use of Sublingual Immunotherapy with Inactivated Whole-Cell Bacterial Extract and Der p1

2020 ◽  
Vol 2020 ◽  
pp. 1-4
Author(s):  
Paula F. Aarestrup ◽  
Matheus F. Aarestrup ◽  
Beatriz J. V. Aarestrup ◽  
Fernando M. Aarestrup
Keyword(s):  
Sublingual Immunotherapy ◽  
Respiratory Infections ◽  
Clinical Manifestations ◽  
Iga Deficiency ◽  
Whole Cell ◽  
Bacterial Extract ◽  
Selective Iga Deficiency ◽  
Concurrent Use ◽  
Airway Infections ◽  
Der P1

Selective IgA deficiency is the most common type of primary immunodeficiency, but there is not yet a specific effective treatment. The most prevalent clinical manifestations are infectious diseases of the respiratory system. We report herein the case of an 11-year-old female with selective IgA deficiency and recurring episodes of respiratory infections associated with rhinitis and asthma. We evaluated the efficacy of sublingual immunotherapy combined with inactivated whole-cell bacterial extract and Der p1-specific immunotherapy. After 18 months of clinical follow-up, we observed a significant reduction in the number of episodes of respiratory infections associated with control of atopic diseases. We also observed a 3-fold increase in serum IgA levels compared to treatment initiation. This case demonstrates the potential utility of the concurrent use of sublingual immunotherapy with inactivated whole-cell bacterial extract and Der p1 for successful control of allergy and infection in partial selective IgA deficiency.

Clinical Manifestations in Selective IgA Deficiency in Childhood; A Follow-up Report

1991 ◽  
Vol 80 (8-9) ◽  
pp. 798-804 ◽  
Author(s):  
P. C. J. DE LAAT ◽  
C. M. R. WEEMAES ◽  
R. GONERA ◽  
P. J. J. VAN MUNSTER ◽  
J. A. J. M. BAKKEREN ◽  
...  
Keyword(s):  
Clinical Manifestations ◽  
Iga Deficiency ◽  
Selective Iga Deficiency

Selective IgA Deficiency, Hypothyroidism and Congenital Lymphoedema

1996 ◽  
Vol 41 (1) ◽  
pp. 22-23 ◽  
Author(s):  
A.L. Jones ◽  
D.J. Webb
Keyword(s):  
Respiratory Infections ◽  
Iga Deficiency ◽  
Selective Iga Deficiency ◽  
Autoimmune Hypothyroidism ◽  
Recurrent Respiratory Infections ◽  
Congenital Lymphoedema

The occurrence of selective IgA deficiency and hypothyroidism with congenital Iymphoedema has never previously been documented, although the association of hypogammaglobulinaemia with congenital Iymphoedema has previously been reported and can result in recurrent respiratory infections. We report a 34 year old woman with congenital Iymphoedema who was found to have symptomatic autoimmune hypothyroidism and asymptomatic selective IgA deficiency.

scholarly journals Selective IgA Deficiency and Allergy: A Fresh Look to an Old Story

Medicina ◽  
2022 ◽  
Vol 58 (1) ◽  
pp. 129
Author(s):  
Bianca Laura Cinicola ◽  
Federica Pulvirenti ◽  
Martina Capponi ◽  
Marta Bonetti ◽  
Giulia Brindisi ◽  
...  
Keyword(s):  
Clinical Manifestations ◽  
Atopic Disease ◽  
Iga Deficiency ◽  
Normal Serum ◽  
Secretory Iga ◽  
Primary Immune Deficiency ◽  
Recurrent Infections ◽  
Selective Iga Deficiency ◽  
The Relationship ◽  
Allergic Disorders

Selective IgA deficiency (SIgAD) is the most common human primary immune deficiency (PID). It is classified as a humoral PID characterized by isolated deficiency of IgA (less than 7 mg/dL but normal serum IgG and IgM) in subjects greater than 4 years of age. Intrinsic defects in the maturation of B cells and a perturbation of Th cells and/or cytokine signals have been hypothesized to contribute to SIgAD pathogenesis. The genetic basis of IgA deficiency remains to be clarified. Patients with SIgAD can be either asymptomatic or symptomatic with clinical manifestations including allergy, autoimmunity and recurrent infections mainly of the respiratory and gastrointestinal tract. Studies analyzing allergy on SIgAD patients showed prevalence up to 84%, supporting in most cases the relationship between sIgAD and allergic disease. However, the prevalence of allergic disorders may be influenced by various factors. Thus, the question of whether allergy is more common in SIgAD patients compared to healthy subjects remains to be defined. Different hypotheses support an increased susceptibility to allergy in subjects with SIgAD. Recurrent infections due to loss of secretory IgA might have a role in the pathogenesis of allergy, and vice versa. Perturbation of microbiota also plays a role. The aim of this review is to examine the association between SIgAD and atopic disease and to update readers on advances over time at this important interface between allergy and SIgAD.

scholarly journals Innate Mechanisms in Selective IgA Deficiency

2021 ◽  
Vol 12 ◽  
Author(s):  
Jingyan Zhang ◽  
Dèlenn van Oostrom ◽  
JianXi Li ◽  
Huub F. J. Savelkoul
Keyword(s):  
Clinical Symptoms ◽  
Clinical Manifestations ◽  
Specific Treatment ◽  
Serum Levels ◽  
Iga Deficiency ◽  
Normal Serum ◽  
Immune Defense ◽  
Selective Iga Deficiency ◽  
Young Infants ◽  
Novel Therapeutic Strategies

Selective IgA deficiency (SIgAD), characterized by a serum IgA level below 0.07 mg/ml, while displaying normal serum levels of IgM and IgG antibodies, is the most frequently occurring primary immunodeficiency that reveals itself after the first four years after birth. These individuals with SIgAD are for the majority healthy and even when they are identified they are usually not investigated further or followed up. However, recent studies show that newborns and young infants already display clinical manifestations of this condition due to aberrancies in their immune defense. Interestingly, there is a huge heterogeneity in the clinical symptoms of the affected individuals. More than 50% of the affected individuals do not have clinical symptoms, while the individuals that do show clinical symptoms can suffer from mild to severe infections, allergies and autoimmune diseases. However, the reason for this heterogeneity in the manifestation of clinical symptoms of the individuals with SIgAD is unknown. Therefore, this review focusses on the characteristics of innate immune system driving T-cell independent IgA production and providing a mechanism underlying the development of SIgAD. Thereby, we focus on some important genes, including TNFRSF13B (encoding TACI), associated with SIgAD and the involvement of epigenetics, which will cover the methylation degree of TNFRSF13B, and environmental factors, including the gut microbiota, in the development of SIgAD. Currently, no specific treatment for SIgAD exists and novel therapeutic strategies could be developed based on the discussed information.

scholarly journals Clinical Features and Maternal-fetal Results of Pregnant Women in COVID-19 Times

2021 ◽  
Vol 43 (05) ◽  
pp. 384-394
Author(s):  
Ana Paula Nogueira Godoi ◽  
Gilcelia Correia Santos Bernardes ◽  
Leilismara Sousa Nogueira ◽  
Patrícia Nessralla Alpoim ◽  
Melina de Barros Pinheiro
Keyword(s):  
Pregnant Women ◽  
Vertical Transmission ◽  
Postpartum Period ◽  
Scientific Literature ◽  
Respiratory Infections ◽  
Clinical Manifestations ◽  
Fetal Distress ◽  
Medical Subject Headings ◽  
Substantial Evidence ◽  
The Subject

Abstract Objective Coronavirus disease 2019 (COVID-19) is a disease caused by a newly discovered coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which usually leads to non-specific respiratory symptoms. Although pregnant women are considered at risk for respiratory infections by other viruses, such as SARS and Middle East respiratory syndrome (MERS), little is known about their vulnerability to SARS-CoV-2. Therefore, this study aims to identify and present the main studies on the topic, including the postpartum period. Methods In this narrative review, articles were searched in various databases, organizations, and health entities using keywords compatible with medical subject headings (MeSH), such as: COVID-19, pregnancy, vertical transmission, coronavirus 2019, and SARS-CoV-2. Results The review of the scientific literature on the subject revealed that pregnant women with COVID-19 did not present clinical manifestations significantly different from those of non-pregnant women; however, there are contraindicated therapies. Regarding fetuses, studies were identified that reported that infection by SARS-CoV-2 in pregnant women can cause fetal distress, breathing difficulties and premature birth, but there is no substantial evidence of vertical transmission. Conclusion Due to the lack of adequate information and the limitations of the analyzed studies, it is necessary to provide detailed clinical data on pregnant women infected with SARS-CoV-2 and on the maternal-fetal repercussions caused by this infection. Thus, this review may contribute to expand the knowledge of professionals working in the area as well as to guide more advanced studies on the risk related to pregnant women and their newborns. Meanwhile, monitoring of confirmed or suspected pregnant women with COVID-19 is essential, including in the postpartum period.

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