In Vivo Confocal Microscopy and Anterior Segment Optical Coherence Tomography Analysis of the Microcystic Keratitis

Purpose. To describe the findings of in vivo confocal microscopy (IVCM) and anterior segment optical coherence tomography (AS-OCT) in a case of bilateral acute microcystic epitheliopathy after daily soft contact lens wear. Methods. IVCM and AS-OCT were used in the course of the bilateral epitheliopathy of a 23-year-old patient at the acute stage of the disease and at recovery after four days of treatment. The images were analyzed and compared. Results. On AS-OCT of the right eye, general hyperreflectivity and the increased thickness of the central corneal epithelium to 150 μm with numerous hyporeflective small, oval cysts were revealed and resolved completely at day 4 after diagnosis and treatment. AS-OCT scans of the left eye revealed oval shaped, hyperreflective material within the corneal epithelium. IVCM of both eyes showed numerous microcysts of different sizes filled with hyperreflective material mostly within superficial epithelial layers. Epithelial cells showed a polymorphism along with disruption of a cytoarchitecture. Basal epithelial cells and anterior stroma showed inflammatory changes. Posterior corneal stroma and endothelium presented normal morphology. Conclusions. Microcystic keratitis appeared as localized microcystic inflammation of epithelium on AS-OCT, which was confirmed by IVCM. Both IVCM and AS-OCT are helpful diagnostic instruments in case of cystic inflammation of corneal epithelium.

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Characteristics of Linear Interstitial Keratitis by In Vivo Confocal Microscopy and Anterior Segment Optical Coherence Tomography

Cornea ◽

10.1097/ico.0000000000001552 ◽

2018 ◽

Vol 37 (6) ◽

pp. 785-788

Author(s):

Aleksandra Petrovic ◽

Kattayoon Hashemi ◽

Frank Blaser ◽

Wolfgang Wild ◽

George Kymionis

Keyword(s):

Optical Coherence Tomography ◽

Confocal Microscopy ◽

Anterior Segment ◽

Optical Coherence ◽

In Vivo Confocal Microscopy ◽

Interstitial Keratitis

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Clinical and morphological manifestations of aniridia-associated keratopathy on anterior segment optical coherence tomography and in vivo confocal microscopy

The Ocular Surface ◽

10.1016/j.jtos.2017.07.001 ◽

2017 ◽

Vol 15 (4) ◽

pp. 759-769 ◽

Cited By ~ 6

Author(s):

Anna Voskresenskaya ◽

Nadezhda Pozdeyeva ◽

Tatyana Vasilyeva ◽

Yevgeniy Batkov ◽

Aleksandr Shipunov ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Confocal Microscopy ◽

Anterior Segment ◽

Optical Coherence ◽

In Vivo Confocal Microscopy

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Examination of corneal deposits in nephropathic cystinosis using in vivo confocal microscopy and anterior segment optical coherence tomography: an age-dependent cross sectional study

BMC Ophthalmology ◽

10.1186/s12886-020-01336-w ◽

2020 ◽

Vol 20 (1) ◽

Cited By ~ 1

Author(s):

Anita Csorba ◽

Erika Maka ◽

Otto Alexander Maneschg ◽

Attila Szabó ◽

Nóra Szentmáry ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Confocal Microscopy ◽

Anterior Segment ◽

Interquartile Range ◽

Nephropathic Cystinosis ◽

Optical Coherence ◽

In Vivo Confocal Microscopy ◽

Crystal Deposition ◽

Crystal Density

Abstract Background Presence of corneal cystine crystals is the main ocular manifestation of cystinosis, although controversial findings concerning the corneal layer with the highest density have been reported. The aim of this study was the analysis of the characteristics of crystal arrangement in different corneal layers and the assessment of corneal morphological changes with age. Methods A cross sectional study was carried out in three children and three adults who had nephropathic cystinosis and corneal cystine depositions. All patients underwent a comprehensive ophthalmological examination including best corrected distance visual acuity, slit-lamp examination, in vivo confocal microscopy and anterior segment optical coherence tomography. An evaluation of the depth of crystal deposits and crystal density in different corneal layers was also performed. Due to the low number of subjects no statistical comparison was performed. Results Anterior segment optical coherence tomography images revealed deposition of hyperreflective crystals from limbus to limbus in each patient. Crystals appeared as randomly oriented hyperreflective, elongated structures on in vivo confocal microscopy images in all corneal layers except the endothelium. In children the deposits occurred predominantly in the anterior stroma, while in adults, the crystals were mostly localized in the posterior corneal stroma with the depth of crystal deposition showing an increasing tendency with age (mean depth of crystal density was 353.17 ± 49.23 μm in children and it was 555.75 ± 25.27 μm in adults). Mean crystal density of the epithelium was 1.47 ± 1.17 (median: 1.5; interquartile range: 0.3–2.4). Mean crystal density of the anterior and posterior stroma of children and adults was 3.37 ± 0.34 (median: 3.4; interquartile range: 3.25–3.55) vs. 1.23 ± 0.23 (median: 1.2; interquartile range: 1.05–1.35) and 0.76 ± 0.49 (median: 0.7; interquartile range: 0.4–1.15) vs. 3.63 ± 0.29 (median: 3.7; interquartile range: 3.45–3.8), respectively. Endothelium had intact structure in all cases. Some hexagonal crystals were observed in two subjects. Conclusions In vivo confocal microscopy and anterior segment optical coherence tomography confirmed an age-related pattern of crystal deposition. In children, crystals tend to locate anteriorly, while in adults, deposits are found posteriorly in corneal stroma.

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