A Rare Case of Histiocytic Sarcoma Secondary to Gastrointestinal Stromal Tumor in the Stomach: Transdifferentiation or Synchronicity?

Case Reports in Hematology ◽

10.1155/2021/8856649 ◽

2021 ◽

Vol 2021 ◽

pp. 1-6

Author(s):

Jiankun Tong ◽

Jean Luo ◽

Pierre F. Saldinger ◽

William H. Rodgers

Keyword(s):

Gastrointestinal Stromal Tumor ◽

Rare Case ◽

Histiocytic Sarcoma ◽

The Body ◽

Stromal Tumor

Histiocytic sarcoma is a rare malignant histiocytic neoplasm composed of cells with morphologic and immunophenotypic features of mature tissue histiocytes. It occurs anywhere in the body and behaves aggressively. However, its etiology is unknown. Here, we report a 68-year-old female who developed histiocytic sarcoma following chemotherapy with imatinib (Gleevec) for gastrointestinal stromal tumor. Possible mechanisms of transdifferentiation from gastrointestinal stromal tumor to histiocytic sarcoma are discussed based on the features of our case and other two similar cases in the literature.

Download Full-text

Gastric schwannoma: a benign tumor often misdiagnosed as gastrointestinal stromal tumor

Clinics and Practice ◽

10.4081/cp.2015.775 ◽

2015 ◽

Vol 5 (3) ◽

Cited By ~ 7

Author(s):

Apurva S. Shah ◽

Pravin M. Rathi ◽

Vaibhav S. Somani ◽

Astha M. Mulani

Keyword(s):

Differential Diagnosis ◽

Gastrointestinal Stromal Tumor ◽

Gastrointestinal Stromal Tumors ◽

Rare Case ◽

Benign Tumor ◽

Stromal Tumor ◽

Mesenchymal Tumors ◽

Stromal Tumors ◽

Gastric Schwannoma ◽

Gastric Mass

Gastric schwannomas are rare mesenchymal tumors that arise from the nerve plexus of gut wall. They present with nonspecific symptoms and are often detected incidentally. Preoperative investigation is not pathognomic and many are therefore misdiagnosed as gastrointestinal stromal tumors. We report a rare case of a 37-year old woman who underwent laparotomy for complex bilateral ovarian cyst with resection of gastric-gastrointestinal stromal tumor preoperatively, but confirmed to have a gastric schwannomas postoperatively. This case underscores the differential diagnosis of submucosal, exophytic gastric mass as schwannoma.

Download Full-text

TOMOGRAPHIC FINDINGS OF GASTRIC GASTROINTESTINAL STROMAL TUMOR AND CORRELATION WITH THE MITOTIC INDEX

Arquivos de Gastroenterologia ◽

10.1590/s0004-28032013000400002 ◽

2013 ◽

Vol 50 (4) ◽

pp. 244-250 ◽

Cited By ~ 2

Author(s):

Gustavo Lemos PELANDRÉ ◽

Maria Célia DJAHJAH ◽

Emerson Leandro GASPARETTO ◽

Marcelo Souto NACIF ◽

Edson MARCHIORI ◽

...

Keyword(s):

Gastrointestinal Stromal Tumor ◽

Mitotic Index ◽

Statistical Correlation ◽

Gastric Fundus ◽

The Body ◽

Stromal Tumor ◽

Gastric Body ◽

Dense Area ◽

Stromal Tumors ◽

Mesenteric Fat

ContextGastrointestinal stromal tumors are uncommon abdominal neoplasms and can affect any portion of the gastrointestinal tract.ObjectivesDescribe the tomographic findings of the gastrointestinal stromal tumor of gastric origin, correlating it with the mitotic index.MethodsTwenty-one patients were selected within the period of January 2000 and 2008, with histopathological and immunohistochemical diagnosis of gastric gastrointestinal stromal tumors, who presented computed tomography done before the treatment. The tomographic variables analyzed were lesion topography, dimensions, contours, morphology, pattern and intensity enhancement through venous contrast, growth pattern, invasion of adjacent organs, presence of ulceration, fistula, calcifications, infiltration of mesenteric fat, lymphadenopathy and metastasis. The mitotic index was determined through optic microscopy, counting the number of mitosis figures in 50 high power fields.ResultsThe tumors were located in the body (66.7%) or gastric fundus (33.3%), with dimensions varying between 4.2 and 21.2 cm (average of 10.5 cm). The growth was predominantly extraluminal (47.6%) or intra/extra luminal (28.6%). The enhancement by venous contrast was heterogeneous in 66.7%. The statistical analysis showed that irregular morphology (P = 0.027) and infiltration of mesenteric fat (P = 0.012) presented correlation with the high mitotic index.ConclusionsIn the present study, most part of the tumors were located in the gastric body, with average size of 10.5 cm, presenting central hypo dense area, heterogeneous enhancement through contrast and predominantly extra luminal growth. Irregular morphology and infiltration of mesenteric fat present statistical correlation with high mitotic level.

Download Full-text