GABA Withdrawal Modifies Network Activity in Cultured Hippocampal Neurons
Keyword(s):
Dissociated hippocampal neurons, grown in culture for 2 to 3 weeks, tended to fire bursts of synaptic currents at fairly regular intervals, representing network activity. A brief exposure of cultured neurons to GABA caused a total suppression of the spontaneous network activity. Following a washout of GABA, the activity was no longer clustered in bursts and instead, the cells fired at a high rate tonic manner. The effect of removing GABA could be seen as long as 1 to 2 days after GABA withdrawal and is expressed as an increase in the number of active cells in a network, as well as in their firing rates. Such striking effects of GABA removal may underlie part of the GABA withdrawal syndrome seen elsewhere.
2008 ◽
Vol 438
(3)
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pp. 356-361
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1998 ◽
Vol 18
(17)
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pp. 6822-6829
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2011 ◽
Vol 2
(3)
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pp. 259-268