Abstract A195: A novel selective estrogen receptor degrader, EC-372, inhibits tumor growth and metastasis of breast cancer cells

2018 ◽  
Author(s):  
Deepak Parashar ◽  
Anjali Geethadevi ◽  
Jyotsna Mishra ◽  
Bindu Nair ◽  
Bindu Santhamma ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Tumor Growth ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Tumor Growth And Metastasis

scholarly journals Smad4 Inhibits Tumor Growth by Inducing Apoptosis in Estrogen Receptor-α-positive Breast Cancer Cells

2005 ◽  
Vol 280 (29) ◽  
pp. 27022-27028 ◽  
Author(s):  
Qingnan Li ◽  
Liyu Wu ◽  
Denise K. Oelschlager ◽  
Mei Wan ◽  
Cecil R. Stockard ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Tumor Growth ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Estrogen Receptor Α ◽  
Positive Breast Cancer

Tumor Endothelial Marker 8 Overexpression in Breast Cancer Cells Enhances Tumor Growth and Metastasis

2011 ◽  
Vol 29 (10) ◽  
pp. 676-682 ◽  
Author(s):  
Michael Opoku-Darko ◽  
Carol Yuen ◽  
Katherine Gratton ◽  
Elliot Sampson ◽  
Oliver F. Bathe
Keyword(s):  
Breast Cancer ◽  
Tumor Growth ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Tumor Growth And Metastasis ◽  
Tumor Endothelial Marker 8 ◽  
Endothelial Marker

scholarly journals Herbal Extract SH003 Suppresses Tumor Growth and Metastasis of MDA-MB-231 Breast Cancer Cells by Inhibiting STAT3-IL-6 Signaling

2014 ◽  
Vol 2014 ◽  
pp. 1-11 ◽  
Author(s):  
Youn Kyung Choi ◽  
Sung-Gook Cho ◽  
Sang-Mi Woo ◽  
Yee Jin Yun ◽  
Sunju Park ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Growth ◽  
Cancer Cells ◽  
Cancer Progression ◽  
Breast Cancer Cells ◽  
Metastatic Breast ◽  
Herbal Extract ◽  
Tumor Growth And Metastasis ◽  
Risk Of Cancer

Cancer inflammation promotes cancer progression, resulting in a high risk of cancer. Here, we demonstrate that our new herbal extract, SH003, suppresses both tumor growth and metastasis of MDA-MB-231 breast cancer cells via inhibiting STAT3-IL-6 signaling path. Our new herbal formula, SH003, mixed extract fromAstragalus membranaceus, Angelica gigas, andTrichosanthes kirilowiiMaximowicz, suppressed MDA-MB-231 tumor growth and lung metastasisin vivoand reduced the viability and metastatic abilities of MDA-MB-231 cellsin vitro. Furthermore, SH003 inhibited STAT3 activation, which resulted in a reduction of IL-6 production. Therefore, we conclude that SH003 suppresses highly metastatic breast cancer growth and metastasis by inhibiting STAT3-IL-6 signaling path.

scholarly journals Scavenging of CXCL12 by CXCR7 promotes tumor growth and metastasis of CXCR4-positive breast cancer cells

Oncogene ◽  
2012 ◽  
Vol 31 (45) ◽  
pp. 4750-4758 ◽  
Author(s):  
K E Luker ◽  
S A Lewin ◽  
L A Mihalko ◽  
B T Schmidt ◽  
J S Winkler ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Growth ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Tumor Growth And Metastasis ◽  
Positive Breast Cancer
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