Abstract PD5-3: Phase I trial: PI3Kα inhibitor BYL719 plus aromatase inhibitor (AI) for patients with hormone receptor-positive (HR+) metastatic breast cancer (MBC)

Author(s):

Payal D Shah ◽

Mary Ellen Moynahan ◽

Shanu Modi ◽

Betty Ann Caravella ◽

Farrah M Datko ◽

...

Keyword(s):

Breast Cancer ◽

Phase I ◽

Aromatase Inhibitor ◽

Hormone Receptor ◽

Phase I Trial ◽

Metastatic Breast ◽

Abstract CT330: Phase I study of PI3Kα inhibitor BYL719 + aromatase inhibitor (AI) in patients (pts) with hormone receptor-positive (HR+) metastatic breast cancer (MBC)

10.1158/1538-7445.am2015-ct330 ◽

2015 ◽

Cited By ~ 3

Author(s):

Payal D. Shah ◽

Mary E. Moynahan ◽

Shanu Modi ◽

Nicola Hamilton ◽

Betty Ann Caravella ◽

...

Keyword(s):

Breast Cancer ◽

Phase I ◽

Aromatase Inhibitor ◽

Hormone Receptor ◽

Phase I Study ◽

Metastatic Breast ◽

Phase I trial of exemestane in combination with metformin and rosiglitazone in nondiabetic obese postmenopausal women with hormone receptor–positive metastatic breast cancer

Cancer Chemotherapy and Pharmacology ◽

10.1007/s00280-012-1977-9 ◽

2012 ◽

Vol 71 (1) ◽

pp. 63-72 ◽

Cited By ~ 27

Author(s):

Francisco J. Esteva ◽

Stacy L. Moulder ◽

Ana M. Gonzalez-Angulo ◽

Joe Ensor ◽

James L. Murray ◽

...

Keyword(s):

Breast Cancer ◽

Phase I ◽

Postmenopausal Women ◽

Hormone Receptor ◽

Phase I Trial ◽

Metastatic Breast ◽

Phase I/II study of sorafenib with anastrozole in patients with hormone receptor positive aromatase inhibitor resistant metastatic breast cancer

Breast Cancer Research and Treatment ◽

10.1007/s10549-010-1226-z ◽

2010 ◽

Vol 125 (1) ◽

pp. 137-143 ◽

Cited By ~ 24

Author(s):

Claudine Isaacs ◽

Pia Herbolsheimer ◽

Minetta C. Liu ◽

Mary Wilkinson ◽

Yvonne Ottaviano ◽

...

Keyword(s):

Breast Cancer ◽

Phase I ◽

Aromatase Inhibitor ◽

Hormone Receptor ◽

Metastatic Breast ◽

A phase I trial of tipifarnib, a farnesyltransferase inhibitor, and tamoxifen in hormone-receptor positive metastatic breast cancer

10.1200/jco.2004.22.14_suppl.644 ◽

2004 ◽

Vol 22 (14_suppl) ◽

pp. 644-644 ◽

Author(s):

P. F. Lebowitz ◽

J. Eng-Wong ◽

F. Balis ◽

B. Widemann ◽

N. Jayaprakash ◽

...

Keyword(s):

Breast Cancer ◽

Phase I ◽

Hormone Receptor ◽

Phase I Trial ◽

Metastatic Breast ◽

Farnesyltransferase Inhibitor ◽

A phase I trial of tipifarnib, a farnesyltransferase inhibitor, and tamoxifen in hormone-receptor positive metastatic breast cancer

10.1200/jco.2004.22.90140.644 ◽

2004 ◽

Vol 22 (14_suppl) ◽

pp. 644-644

Author(s):

P. F. Lebowitz ◽

J. Eng-Wong ◽

F. Balis ◽

B. Widemann ◽

N. Jayaprakash ◽

...

Keyword(s):

Breast Cancer ◽

Phase I ◽

Hormone Receptor ◽

Phase I Trial ◽

Metastatic Breast ◽

Farnesyltransferase Inhibitor ◽

Phase I trial of daily PI3Kα inhibitor BYL719 plus letrozole (L) or exemestane (E) for patients (pts) with hormone receptor-positive (HR+) metastatic breast cancer (MBC).

10.1200/jco.2014.32.15_suppl.2605 ◽

2014 ◽

Vol 32 (15_suppl) ◽

pp. 2605-2605 ◽

Author(s):

Payal Deepak Shah ◽

Shanu Modi ◽

Farrah Mikhail Datko ◽

Mary Ellen Moynahan ◽

Stephen Zamora ◽

...

Keyword(s):

Breast Cancer ◽

Phase I ◽

Hormone Receptor ◽

Phase I Trial ◽

Metastatic Breast ◽

Phase I/II dose-escalation study of PI3K inhibitors pilaralisib or voxtalisib in combination with letrozole in patients with hormone-receptor-positive and HER2-negative metastatic breast cancer refractory to a non-steroidal aromatase inhibitor

Breast Cancer Research and Treatment ◽

10.1007/s10549-015-3615-9 ◽

2015 ◽

Vol 154 (2) ◽

pp. 287-297 ◽

Cited By ~ 14

Author(s):

Kimberly Blackwell ◽

Howard Burris ◽

Patricia Gomez ◽

N. Lynn Henry ◽

Steven Isakoff ◽

...

Keyword(s):

Breast Cancer ◽

Phase I ◽

Aromatase Inhibitor ◽

Dose Escalation ◽

Hormone Receptor ◽

Metastatic Breast ◽

Dose Escalation Study ◽

Pi3k Inhibitors ◽

PD01-01: Randomized Phase II Trial of Fulvestrant with or without Dasatinib in Postmenopausal Patients with Hormone Receptor-Positive Metastatic Breast Cancer Previously Treated with an Aromatase Inhibitor.

10.1158/0008-5472.sabcs11-pd01-01 ◽

2011 ◽

Cited By ~ 6

Author(s):

GL Wright ◽

J Blum ◽

LK Krekow ◽

KJ McIntyre ◽

ST Wilks ◽

...

Keyword(s):

Breast Cancer ◽

Aromatase Inhibitor ◽

Phase Ii ◽

Hormone Receptor ◽

Phase Ii Trial ◽

Metastatic Breast ◽

Hormone Receptor Positive ◽

Randomized Phase Ii ◽

Previously Treated

Phase I/II study of letrozole and sorafenib as first-line therapy of hormone-receptor positive (HR+) metastatic breast cancer (MBC).

10.1200/jco.2014.32.15_suppl.531 ◽

2014 ◽

Vol 32 (15_suppl) ◽

pp. 531-531

Author(s):

Antoinette R. Tan ◽

Serena Tsan-Lai Wong ◽

Robert D. Warren ◽

Jennifer Eng-Wong ◽

Minetta C. Liu ◽

...

Keyword(s):

Breast Cancer ◽

Phase I ◽

Hormone Receptor ◽

Metastatic Breast ◽

First Line ◽

First Line Therapy ◽

Hormone Receptor Positive ◽

Line Therapy

Sacituzumab govitecan in previously treated hormone receptor-positive/HER2-negative metastatic breast cancer: final results from a phase I/II, single-arm, basket trial

Annals of Oncology ◽

10.1016/j.annonc.2020.09.004 ◽

2020 ◽

Vol 31 (12) ◽

pp. 1709-1718 ◽

Author(s):

K. Kalinsky ◽

J.R. Diamond ◽

L.T. Vahdat ◽

S.M. Tolaney ◽

D. Juric ◽

...

Keyword(s):

Breast Cancer ◽

Phase I ◽

Hormone Receptor ◽

Metastatic Breast ◽

Hormone Receptor Positive ◽

Previously Treated ◽

Basket Trial