Adrenocortical Carcinoma Evolving after Diagnosis of Preclinical Cushing’s Syndrome in an Adrenal Incidentaloma

1998 ◽  
Vol 50 (4) ◽  
pp. 237-242 ◽  
Author(s):  
G. Höfle ◽  
R.W. Gasser ◽  
K. Lhotta ◽  
G. Janetschek ◽  
A. Kreczy ◽  
...  
1969 ◽  
Vol 60 (4) ◽  
pp. 657-668 ◽  
Author(s):  
Frances J. Thomas ◽  
A. W. Steinbeck

ABSTRACT A modified method for the estimation of urinary pregnanetriol, pregnanetriol, pregnanetriolone, Δ5-pregnenetriol and tetrahydro S was investigated. The steroids, separated by chromatography, were measured quantitatively, tetrahydro S by reaction with blue tetrazolium and the other three as acetaldehydogenic substances. The excretion of these steroids was studied in suspected instances of adrenal and/or ovarian disease. Urinary pregnanetriol and tetrahydro S levels were normal in Cushing's syndrome, secondary adrenocortical carcinoma, the Stein-Leventhal syndrome, idiopathic hirsutism and hypertension. Tetrahydro S was doubtfully elevated in an instance of ectopic ACTH Cushing's syndrome. Pregnanetriol excretion was elevated in untreated cases of congenital adrenal hyperplasia and after treatment in some. Pregnanetriolone was found in all patients with congenital adrenal hyperplasia, including those receiving cortisone. Pregnanetriolone was also detected in Cushing's syndrome, secondary adrenocortical carcinoma, the Stein-Leventhal syndrome, ectopic ACTH Cushing's syndrome and suspected congenital adrenal hyperplasia. Δ5-pregnenetriol was present as a glucuronide in the Stein-Leventhal syndrome and idiopathic hirsutism. The diagnostic implications of these results are discussed.


1984 ◽  
Vol 51 (4) ◽  
pp. 497-500 ◽  
Author(s):  
S. Garg ◽  
R. K. Marwaha ◽  
I. C. Pathak ◽  
R. J. Dash

1998 ◽  
Vol 48 (1) ◽  
pp. 89-97 ◽  
Author(s):  
Terzolo ◽  
Osella ◽  
Alì ◽  
Borretta ◽  
Cesario ◽  
...  

1970 ◽  
Vol 22 (1) ◽  
pp. 142-143
Author(s):  
M Nowshad Ali ◽  
S Hoq Miah ◽  
M Meharunnesa ◽  
SM Badruddoza ◽  
Mushtaque Ahmed

Adrenocortical carcinoma is an uncommon tumour in the pediatric population. Account for only a small fraction of pediatric adrenal tumour. Most tumors in children are functional, and virilization is by far the most common presenting symptom, followed by Cushing's syndrome and precocious puberty. All patients with suspected adrenocortical carcinoma should be carefully evaluated for signs and symptoms of hormonal syndromes. DOI: 10.3329/taj.v22i1.5039 TAJ 2009; 22(1): 142-143


2013 ◽  
Vol 3 ◽  
pp. 32 ◽  
Author(s):  
Santosh Kumar ◽  
Gautam R. Choudhary ◽  
Arawat Pushkarna

Adrenocortical carcinoma (ACC) is a rare malignancy with poor prognosis. Surgery is the only curative therapy available and overall 5-year survival for patients who undergo a complete resection is 32% to 48%. They are known to produce intravascular invasion and into the inferior vena cava (IVC) and in rare cases they may reach the right atrium. We report a case of functioning ACC extending into the inferior vena cava and right atrium in a female with Cushing's syndrome.


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