Metabolic Syndrome
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2022 ◽  
Vol 88 ◽  
pp. 104869
Author(s):  
Ju Kyoung Oh ◽  
Robie Vasquez ◽  
Sang Hoon Kim ◽  
Je Hyeon Lee ◽  
Eun Joo Kim ◽  
...  

Author(s):  
Nermine Saleh ◽  
Ansam Aly Seif ◽  
Ienass Bahaa ◽  
Enas A. Abdel-Hady

Metabolic syndrome (MetS) is a cluster of cardiovascular risk factors including central obesity, hypertension, insulin resistance, dyslipidemia, and hyperglyemia. MetS is found to be a positive predictor of cardiovascular morbidity and mortality. The present study was planned to test the efficacy of vitamin D3 supplementation as compared to cortisol inhibition on MetS parameters. Wistar rats were allocated into four groups: controls, untreated MetS, and MetS treated with either vitamin D3 (10 μg/kg), or carbenoxolone (50 mg/kg). MetS was induced by combination of high fat diet and oral fructose. After the induction period (8 weeks), MetS was confirmed and treatment modalities started for a further 4 weeks. Compared to untreated MetS, vitamin D3 and carbenoxolone treated rats showed significant reduction in blood pressure, body mass index, lee index, waist circumference, retroperitoneal fat, and improvement of dyslipidemia. Meanwhile, treatment with carbenoxolone significantly lowered the elevated liver enzymes, vitamin D3 resulted in improved insulin sensitivity, enhanced glucose uptake by muscles and replenished glycogen content in the liver and muscles near control levels. In conclusion, although treatment with vitamin D3 or carbenoxolone reduced the risk factors associated with MetS, vitamin D3 was effective in ameliorating insulin resistance which is the hallmark of MetS.


2021 ◽  
Author(s):  
Guqiao Nie ◽  
Jing Jing Wan ◽  
Lei Jiang ◽  
Shu Kai Hou ◽  
Wen Peng

Abstract Background:The prevalence of metabolic syndrome in the elderly is gradually increasing,which accounts for the largest burden of non-communicable diseases worldwide and has direct effects on health. Research on the relationship between uric acid and metabolic syndrome in the elderly is relatively lacking. The purpose of this study is to explore the diagnostic value of uric acid levels for metabolic syndrome, compared to other components of metabolic syndrome.Materials and methods:We collected the physical examination data of 1,267 elderly people in the community in Wuhan, and used SPSS IBM 22.0 for data analysis. Perform correlation analysis, logistic regression analysis and draw ROC curve. Results:The prevalence of hyperuricemia was 28.1%, and metabolic syndrome was 18.6%; the uric acid level of the non-metabolic syndrome group was lower than that of the metabolic syndrome group (337.31 vs 381.91 µmol/ L; P<0.05); Pearson analysis revealed uric acid levels are correlated with blood pressure, BMI, triglyceride, high-density lipoprotein cholesterol. Logistic regression analysis results suggest that uric acid is a risk factor for metabolic syndrome. Metabolic syndrome components TG and HDL levels are also related to uric acid levels. The result is described as OR value and 95% CI (OR 1.003 [1.001, 1.005]). By drawing the ROC curve, we found that the area under the curve for uric acid to diagnose metabolic syndrome is 0.64 (sensitivity: 79.3%, specificity: 45.1%), which is similar to other components of metabolic syndrome. Conclusion:We confirmed the correlation between uric acid levels and metabolic syndrome in the elderly Chinese population.


Author(s):  
Niina Pitkänen ◽  
Armin Finkenstedt ◽  
Claudia Lamina ◽  
Markus Juonala ◽  
Mika Kähönen ◽  
...  

Abstract Objectives In the general population, increased afamin concentrations are associated with the prevalence and incidence of metabolic syndrome as well as type 2 diabetes. Although metabolic syndrome is commonly associated with nonalcoholic fatty liver disease (NAFLD), there exist no information on afamin and NAFLD. Methods Afamin concentrations were cross-sectionally measured in 146 Austrian patients with NAFLD, in 45 patients without NAFLD, and in 292 age- and sex-matched healthy controls. Furthermore, the feasibility of afamin to predict incident NAFLD was evaluated in 1,434 adult participants in the population-based Cardiovascular Risk in Young Finns Study during a 10-year follow-up. Results Median afamin concentrations were significantly higher in NAFLD patients (83.6 mg/L) than in patients without NAFLD (61.6 mg/L, p<0.0001) or in healthy controls (63.9 mg/L, p<0.0001). In age- and sex-adjusted logistic regression analyses a 10 mg/L increase of afamin was associated with a 1.5-fold increase of having NAFLD as compared with patients without NAFLD and the risk was even two-fold when compared with healthy controls. In the population-based cohort, afamin concentrations at baseline were significantly lower in participants without NAFLD (n=1,195) than in 239 participants who developed NAFLD (56.5 vs. 66.9 mg/L, p<0.0001) during the 10-year follow up, with highest afamin values observed in individuals developing severe forms of NAFLD. After adjustment for several potentially confounding parameters, afamin remained an independent predictor for the development of NAFLD (OR=1.37 [95% CI 1.23–1.54] per 10 mg/L increase, p<0.0001). Conclusions Afamin concentrations are increased in patients with NAFLD and independently predict the development of NAFLD in a population-based cohort.


2021 ◽  
pp. jim-2021-002071
Author(s):  
Sara Cetin Sanlialp ◽  
Gokay Nar ◽  
Rukiye Nar

The prevalence of metabolic syndrome (MetS) is more common in patients with hypertension and is associated with an increased risk of target organ damage and/or cardiovascular disease (CVD). Omentin-1 is a beneficial adipokine considered to play a role in MetS and MetS-related states such as obesity, diabetes, and coronary artery disease. The aim of this study was to determine the relationship between circulating omentin-1 levels and MetS uncomplicated by diabetes or CVD (nascent MetS) in patients with hypertension. In this study, 110 patients (54 men, 49%; average age: 49.72±11.32 years) treated for hypertension but without overt diabetes and/or CVD were enrolled. 66 patients were stratified into MetS (+) (group 1) and 44 patients into MetS (−) (group 2) according to the American Heart Association/National Heart, Lung, and Blood Institute criteria. The triglyceride glucose (TyG) index was used to assess insulin resistance. Circulating omentin-1 levels in venous blood samples were measured by an ELISA kit. Circulating omentin-1 levels in patients with MetS were significantly lower than in patients without MetS (46.35 ng/mL (42.70–57.70 ng/mL) vs 130.95 ng/mL (62.83–236.48 ng/mL), p<0.001). Omentin-1 was inversely correlated with TyG index (r=−0.204, p=0.033). In a multivariate logistic regression analysis, omentin-1, TyG index, and body mass index were independent predictors of MetS. A receiver operating characteristic curve analysis determined that the best cut-off value for omentin-1 in predicting MetS was 62.20 ng/mL and the area under the curve was 0.880 (95% CI 0.817 to 0.942, p<0.001). The findings of this study suggest that circulating omentin-1 levels are inversely related to the presence of MetS and may be a reliable marker to predict the development of MetS in patients with hypertension.


2021 ◽  
Vol 1 (30) ◽  
pp. 30-37
Author(s):  
L. B. Drygina ◽  
A. O. Pyatibrat ◽  
O. M. Astafiev ◽  
I. I. Shantyr ◽  
G. G. Rodionov

Based on a long-term dynamic study of the state of health of liquidators of the consequences of the Chernobyl accident, it was found that 75 % of patients have a metabolic syndrome, burdened with concomitant somatic pathology. The article presents literature data on the key role of adipokine levels in the development of the metabolic syndrome of adipose tissue, hormonal indicators, vitamins and other nutrients, which require modern methods of laboratory diagnostics to determine.The aim. To develop a clinical and laboratory algorithm for diagnosing metabolic syndrome in liquidators of the consequences of the Chernobyl accident using new medical technologies.Methods. 122 liquidators of the consequences of the Chernobyl accident with cerebrovascular diseases, diseases of the digestive system and endocrine system pathology were examined. Based on the International recommendations of 2009, two groups were formed: those with the absence (n = 32) and the presence (n = 90) of metabolic syndrome (MS). The control group consisted of 30 people with MS who were examined and treated at the clinic, but did not have contact with radiation. All patients were male, with an average age of 64–66 years. The main biochemical parameters in blood serum were determined. Immunochemiluminescent method was used to determine hormonal parameters. Mass spectrometry was used to determine the indicators of oxidative stress (MDA, fat-soluble vitamins A, E, D, polyunsaturated fatty acids), and trace elements.Results and analysis. A characteristic feature of MS in LPA is a signifcantly (p < 0.05) low level of total testosterone in the blood serum and the calculated ratio of testosterone/estradiol. With increasing number of MS components signifcantly (p < 0.05) increases in serum level of basal insulin and HOMA IR, leptin levels, decreases the concentration of adiponectin. The analysis of the obtained results did not reveal signifcant differences in the content of the main markers of MS in LP and patients of the control group with MS. In 25% of LPA with MS, adiponectin values are determined below the lower limit of the reference range (less than 5.6 μg/ml), and the leptin content is higher than 21.0 ng/ml at the upper limit of the reference range of 5.6 ng/ml. there Is a stable tendency to reduce HDL cholesterol. When comparing the studied indicators for MS in patients with MS at the Chernobyl NPP and the control group, a statistically signifcant increase in the concentration of vitamin E (9.7 [6.8–12.7] and 6.3 [5.3–7.7]; p = 0.001) was found by 54 % and a decrease in the level of linoleic acid (230.9 [184.6–293.0] and 262.3 [214.1–426.3]; p = 0.014) by 12 %. A decrease in selenium, zinc, copper and iodine was detected.Conclusion. The results of the study demonstrated that liquidators of the consequences of the Chernobyl accident with metabolic syndrome may develop various pathogenetic variants of MS, which can be clarifed by the proposed additional criteria of the diagnostic algorithm. Identifying the pathogenetic variant of MS opens up the possibility of a personalized approach to MS therapy and prevention of the development of circulatory diseases and diabetes.


2021 ◽  
Vol 57 (4) ◽  
pp. 437-443
Author(s):  
Sergej Nadalin ◽  
Alena Buretić-Tomljanović ◽  
Lena Zatković ◽  
Dalibor Karlović ◽  
Vjekoslav Peitl ◽  
...  

Cilj: Porod carskim rezom kontinuirano se povezuje s povećanim rizikom za pojavu komponenti metaboličkog sindroma kod ispitanika u općoj populaciji, dok su podatci za bolesnike sa shizofrenijom manjkavi i proturječni. U ovom smo istraživanju ispitali pridonosi li, i u kojoj mjeri, vrsta poroda vrijednostima indeksa tjelesne mase (ITM) te koncentracijama lipida i glukoze u plazmi na dvjema skupinama bolesnika sa shizofrenijom koji ne primaju terapiju: u bolesnika s prvom epizodom shizofrenije (N = 48) i u kroničnih bolesnika neadherentnih prema antipsihotičnoj terapiji (N = 83). Ispitanici i metode: Podatci o vrsti poroda i neadherentnosti prema antipsihotičnoj terapiji prikupljeni su iz autoanamneze i heteroanamneze. Određivanje ukupnog kolesterola, LDL kolesterola (engl. low density lipoprotein cholesterol), HDL kolesterola (engl. high density lipoprotein cholesterol), triglicerida i glukoze u plazmi realizirano je nakon 12-satnog gladovanja. Rezultati: Učestalost poroda carskim rezom iznosila je 8,4 %. Koncentracije triglicerida i vrijednosti ITM-a bile su značajno više u bolesnika rođenih carskim rezom u odnosu na bolesnike rođene vaginalnim porodom: 1,5 (0,6 – 4,3) vs. 1,1 (0,3 – 3,1); z = -2,21, p = 0,027. Vrsta poroda pridonosi s približno 3,3 % varijabilnosti koncentracija triglicerida. Zaključci: Naši rezultati upućuju da vrsta poroda utječe u manjoj mjeri na koncentracije triglicerida u plazmi u bolesnika sa shizofrenijom koji nisu na terapiji antipsihotičnim lijekovima. Porod carskim rezom predstavlja rizični čimbenik za povišene koncentracije triglicerida.


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