Effects of Clozapine and Sulpiride on Morphine State-Dependent Memory in the Step-Down Passive Avoidance Test

Pharmacology ◽  
2006 ◽  
Vol 79 (3) ◽  
pp. 149-153 ◽  
Author(s):  
Nazanin Malekmohamadi ◽  
Parviz Heidari ◽  
Mousa Sahebgharani ◽  
Mohammad-Reza Zarrindast
Keyword(s):  
Passive Avoidance ◽  
Passive Avoidance Test ◽  
Avoidance Test ◽  
State Dependent ◽  
Step Down

Influence of Intracerebroventricular Administration of Histaminergic Drugs on Morphine State-Dependent Memory in the Step-Down Passive Avoidance Test

Pharmacology ◽  
2005 ◽  
Vol 74 (2) ◽  
pp. 106-112 ◽  
Author(s):  
Mohammad R. Zarrindast ◽  
Azita Khalilzadeh ◽  
S. Mehdi Rezayat ◽  
Mousa Sahebgharani ◽  
Bijan Djahanguiri
Keyword(s):  
Passive Avoidance ◽  
Passive Avoidance Test ◽  
Intracerebroventricular Administration ◽  
Avoidance Test ◽  
State Dependent ◽  
Step Down

Standardisation and Validation of Acute and Chronic Administration Ketamine at Different Doses to Produce Psychosis Like Behavioural Changes in Mice

2017 ◽  
Vol 9 (01) ◽  
Author(s):  
Monu Yadav ◽  
Milind Parle ◽  
Mamta Sachdeva ◽  
Sameer Dhingra
Keyword(s):  
Passive Avoidance ◽  
Treatment Period ◽  
Forced Swim Test ◽  
Chronic Administration ◽  
Passive Avoidance Test ◽  
Latency Time ◽  
Behavioural Changes ◽  
Avoidance Test ◽  
Swim Test ◽  
Step Down

Psychosis is a complex mental illness, characterised by positive, negative and cognitive symptoms. NMDA receptor antagonists have been established to induce behavioural as well as biochemical changes in rodents similar to psychotic patients. The aim of the present study was to investigate the effective dose and treatment period of ketamine to induce some behavioural changes. The results suggest that acute treatment of ketamine (50 and 100 mg/kg, i.p.) induced hyperlocomotor activity and reduced step down latency time in passive avoidance test, whereas in effective in forced swim test. Further, with the chronic administration of ketamine (50 and 100 mg/kg, i.p.) effective to produced hyperlocomotor activity, reduced the step down latency time in passive avoidance test and enhanced the immobility duration in forced swim test. Moreover, these behavioural changes persisted for 7 days after the treatment period. Thus, our findings suggest that the chronic administration of Ketamine (50 and 100 mg/kg, i.p.) potential to produce behavioural changes, would serve as an effective tool to screen antipsychotic drugs.

Involvement of dopamine D1/D2 receptors on harmane-induced amnesia in the step-down passive avoidance test

2010 ◽  
Vol 634 (1-3) ◽  
pp. 77-83 ◽  
Author(s):  
Mohammad Nasehi ◽  
Morteza Piri ◽  
Maryam Nouri ◽  
Davood Farzin ◽  
Touraj Nayer-Nouri ◽  
...  
Keyword(s):  
Passive Avoidance ◽  
D2 Receptors ◽  
Passive Avoidance Test ◽  
Avoidance Test ◽  
Step Down
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