A Comparison of the Effect of Pentagastrin and Histamine on Gastric Pepsin Secretion in Man

Digestion ◽  
1970 ◽  
Vol 3 (1) ◽  
pp. 25-32 ◽  
Author(s):  
P. Aagaard
1981 ◽  
Vol 16 (2) ◽  
pp. 100-109 ◽  
Author(s):  
Mitsuru Aono ◽  
Motoyuki Moriga ◽  
Haruto Uchino

1988 ◽  
Vol 35 (2) ◽  
pp. 173-176 ◽  
Author(s):  
R. W. Ten Kate ◽  
H. A. R. E. Tuynman ◽  
H. P. M. Festen ◽  
G. Pals ◽  
S. G. M. Meuwissen

1983 ◽  
Vol 7 (3) ◽  
pp. 287
Author(s):  
A.S. Gilroy ◽  
D.J. Sanders ◽  
B.H. Hirst ◽  
A.P. Marr ◽  
S. Zahedi-Asl

1956 ◽  
Vol 34 (2) ◽  
pp. 244-252 ◽  
Author(s):  
K. Kowalewski ◽  
S. T. Norvell Jr. ◽  
Walter C. MacKenzie

Subcutaneous histamine in dogs in a dose of 5 mgm. per kgm. of body weight provoked a significant increase in gastric pepsin secretion over a four-hour period. The increased pepsin production was accompanied by increased secretion of free HCl, increased volume of gastric juice, and elevation of plasma pepsinogen in the same experimental period. Plasma pepsinogen levels, before and after histamine, were investigated in a gastric artery, a gastric vein, the portal vein, a hepatic vein, and a cephalic vein. The enzyme concentration was significantly higher in the gastric vein than in the gastric artery and this difference was accentuated following histamine administration. These findings were attributed to endocrine secretion of pepsinogen by the zymogenic cells of the gastric mucosa. There was no evidence that pepsinogen concentration is altered as the blood traverses the liver.


Sign in / Sign up

Export Citation Format

Share Document