Inferring Disease Mechanisms from Epidemiological Data in Chronic Kidney Disease: Calcium and Phosphorus Metabolism

2009 ◽  
Vol 112 (3) ◽  
pp. c137-c147 ◽  
Author(s):  
Ana Pires ◽  
Teresa Adragão ◽  
Maria João Pais ◽  
José Vinhas ◽  
Hugo Gil Ferreira
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Epidemiological Data ◽  
Phosphorus Metabolism ◽  
Disease Mechanisms ◽  
Calcium And Phosphorus

scholarly journals Current and Emerging Drugs in the Treatment of Anemia in Patients with Chronic Kidney Disease

2020 ◽  
Vol 23 ◽  
pp. 278-288
Author(s):  
Hongzhen Zhong ◽  
Wenshan Lin ◽  
Tianbiao Zhou
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Hypoxia Inducible Factor ◽  
Phosphorus Metabolism ◽  
Common Complication ◽  
Public Attention ◽  
Common Causes ◽  
Incident Heart Failure ◽  
Calcium And Phosphorus ◽  
Erythropoietin Stimulating Agents

Anemia is a common complication of chronic kidney disease (CKD), and its prevalence has shown a tendency to increase in many countries. Anemia is associated with incident heart failure and increases mortality in CKD patients, garnering public attention. Here, we reviewed recent studies about CKD with anemia, and tried to summarize the risks and causes and new progress in the treatment of renal anemia. Among the risks and causes, calcium and phosphorus metabolism disorders should be pointed out along with common causes such as iron and erythropoietin deficiencies, hypoxia, inflammation and uremic toxins, and so on. The new anti-anemia treatments mainly include hematopoietic materials supplementation, erythropoietin-stimulating agents, calcium and phosphorus regulators and hypoxia-inducible factor prolyl hydroxylase inhibitors.

scholarly journals Compromised calcium and phosphorus metabolism in patients with diabetes mellitus and chronic kidney disease

2012 ◽  
Vol 15 (4) ◽  
pp. 74-80 ◽  
Author(s):  
Margarita Stanislavovna Biragova ◽  
Svetlana Alexandrovna Gracheva ◽  
Sergey Andreevich Martynov
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Mineral Metabolism ◽  
Hormone Secretion ◽  
Therapeutic Agents ◽  
Phosphorus Metabolism ◽  
Novel Approach ◽  
Patients With Diabetes ◽  
Per Se ◽  
Calcium And Phosphorus

Disturbance of bone and mineral metabolism (BMM) is one of manifestations of chronic kidney disease (CKD), but its significance goes beyond bone disorders per se. Current discourse is as broad as to include vascular calcification, anemia and arterial hypertension, - conditions increasing mortality in patients with CKD. In this regard the active search for and development of novel approach to correction of BMM is under way. Apart from capacity to normalize calcium and phosphorus metabolism, parathyroid hormone secretion and to reduce morphologic alterations of bone tissue, modern therapeutic agents feature cardio- and renoprotective capabilities, which make them a treatment of choice for compromised BMM in CKD.

Calcium and Phosphorus Homeostasis in Dogs with Spontaneous Chronic Kidney Disease at Different Stages of Severity

2010 ◽  
Vol 24 (1) ◽  
pp. 73-79 ◽  
Author(s):  
O. Cortadellas ◽  
M.J. Fernández del Palacio ◽  
J. Talavera ◽  
A. Bayón
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Calcium And Phosphorus

scholarly journals Impaired platelet P2Y12 inhibition by thienopyridines in chronic kidney disease: mechanisms, clinical relevance and pharmacological options

2013 ◽  
Vol 28 (8) ◽  
pp. 1994-2002 ◽  
Author(s):  
Olivier Morel ◽  
Clotilde Muller ◽  
Laurence Jesel ◽  
Bruno Moulin ◽  
Thierry Hannedouche
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Clinical Relevance ◽  
Disease Mechanisms
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