Serum Concentration and Urinary Excretion of Doxycline in Normal Subjects and Patients with Renal Insufficiency

Chemotherapy ◽  
1974 ◽  
Vol 20 (3) ◽  
pp. 129-140 ◽  
Author(s):  
N.K. Ao ◽  
O.P. Taneja ◽  
V.N. Bhatia ◽  
D.S. Aggarwal
Keyword(s):  
Serum Concentration ◽  
Renal Insufficiency ◽  
Urinary Excretion ◽  
Normal Subjects

ÉTUDES IN VIVO SUR LE MÉTABOLISME DES ANDROGÉNES APRES ADMINISTRATION DE STÉROÏDES INHIBITEURS DE L'OVULATION

1965 ◽  
Vol 50 (1) ◽  
pp. 131-144 ◽  
Author(s):  
P. Mauvais-Jarvis ◽  
M. F. Jayle ◽  
J. Decourt ◽  
J. Louchart ◽  
J. Truffert
Keyword(s):  
Luteinizing Hormone ◽  
Urinary Excretion ◽  
Normal Subjects ◽  
Hormone Activity ◽  
Testosterone Production ◽  
Normal Men ◽  
Ethinyl Oestradiol

ABSTRACT Normal subjects and hirsute women with micropolycystic ovaries were treated with ethinyl-oestrenol + 3-methoxy-ethinyl-oestradiol (Lyndiol®), in view of studying the action of this compound on the production of androgens and on the urinary excretion of their metabolites. In normal men, the production of testosterone and the excretion of androsterone and aetiocholanolone are suppressed, whereas the excretion of other 17-ketosteroids and the production of dehydroepiandrosterone sulphate are unchanged. Moreover, the luteinizing hormone activity (LH) in plasma is depressed. It seems that the preparation inhibits specifically the testicular androgen production, by suppressing the hypothalamo-hypophyseal control of LH. Testosterone production and urinary 17-ketosteroid excretion are modified in the same way in women with Stein-Leventhal's syndrome. Physiopathological and therapeutical implications which come from these results are discussed.

A COMPARISON OF TWO METHODS FOR MEASUREMENT OF ALDOSTERONE SECRETION RATE IN MAN

1966 ◽  
Vol 53 (2) ◽  
pp. 177-188 ◽  
Author(s):  
P. Lund-Johansen ◽  
T. Thorsen ◽  
K. F. Støa
Keyword(s):  
Urinary Excretion ◽  
Normal Subjects ◽  
Secretion Rate ◽  
Aldosterone Secretion ◽  
Simple Method ◽  
Mean Values ◽  
Pathological Conditions ◽  
Significant Difference ◽  
Derivative Method ◽  
The Mean

ABSTRACT A comparison has been made between (A), a relatively simple method for the measurement of aldosterone secretion rate, based on paper chromatography and direct densitometry of the aldosterone spot and (B) a more elaborate isotope derivative method. The mean secretion rate in 9 normal subjects was 112 ± 26 μg per 24 hours (method A) and 135 ± 35 μg per 24 hours (method B). The »secretion rate« in one adrenalectomized subject after the intravenous injection of 250 μg of aldosterone was 230 μg per 24 hours (method A) and 294 μg per 24 hours (method B). There was no significant difference in the mean values, and correlation between the two methods was good (r = 0.80). It is concluded that the densitometric method is suitable for clinical purposes as well as research, being more rapid and less expensive than the isotope derivative method. Method A also measures the urinary excretion of the aldosterone 3-oxo-conjugate, which is of interest in many pathological conditions. The densitometric method is obviously the less sensitive and a prerequisite for its use is an aldosterone secretion of 20—30 μg per 24 hours. Lower values are, however, rare in adults.

Bioavailability of Digoxin and Beta-Methyl-Digoxin

1976 ◽  
Vol 4 (5) ◽  
pp. 352-354
Author(s):  
L Padeletti ◽  
F Fantini ◽  
P Cinelli ◽  
C Gremigni
Keyword(s):  
Single Dose ◽  
Serum Concentration ◽  
Urinary Excretion ◽  
Crossover Study ◽  
Drug Absorption ◽  
Normal Volunteers ◽  
Cumulative Urinary Excretion ◽  
Serial Serum ◽  
Concentration Measurements ◽  
Randomized Crossover Study

In a randomized crossover study the bioavailability of a single dose of digoxin and of beta-methyl-digoxin tablets was tested in four normal volunteers. No difference was found between the two products in the rate and extent of drug absorption using 6 day cumulative urinary excretion and serial serum concentration measurements.

Study of Circadian Rhythmicity of Urinary Excretion of Glycosaminoglycans in Normal Subjects and Stone Formers

Urolithiasis ◽  
1989 ◽  
pp. 243-243
Author(s):  
H. Sidhu ◽  
S. Vaidyanathan ◽  
A. K. Hemal ◽  
S. K. Thind ◽  
R. Nath ◽  
...  
Keyword(s):  
Urinary Excretion ◽  
Normal Subjects ◽  
Circadian Rhythmicity ◽  
Stone Formers

Urinary excretion of glycated protein determined with a specific radioimmunoassay

1991 ◽  
Vol 37 (4) ◽  
pp. 504-507 ◽  
Author(s):  
Chizuko Ukita ◽  
Mitsushige Nishikawa ◽  
Akira Shouzu ◽  
Mitsuo Inada
Keyword(s):  
Urinary Excretion ◽  
Normal Subjects ◽  
Mean Values ◽  
Specific Radioimmunoassay ◽  
Glycated Protein ◽  
Highly Sensitive ◽  
Significant Difference ◽  
Group A ◽  
The Mean ◽  
Group B

Abstract We developed a simple and highly sensitive RIA for glycated protein (GP), and used it to measure GP in serum and urine from 15 normal controls and 30 diabetics (14 with urinary excretion rate of albumin, Ualb less than 15 micrograms/min, group A; nine with 15 less than or equal to Ualb less than or equal to 150 micrograms/min, group B; and seven with Ualb greater than 150 micrograms/min, group C). The mean serum concentration of GP was above normal in all groups of diabetics, and the mean glycation ratios of serum protein (SGP) were higher in groups B and C than in normal subjects. Urinary concentrations of GP also were increased in groups B and C, although the glycation ratio of urinary protein (UGP) was decreased in group C. Consequently, the selectivity of urinary excretion of GP (UGP/SGP) was significantly decreased in group C. Moreover, there was a significant difference in the mean values of selectivity between groups of patients with various degrees of retinopathy. We suggest that measurements of serum and urinary GP are useful to evaluate the progression of diabetic complications.

Intra- and Interindividual Variability in Sodium Intake in Normal Subjects and in Patients With Renal Insufficiency

1986 ◽  
Vol 7 (5) ◽  
pp. 375-380 ◽  
Author(s):  
Friedrich C. Luft ◽  
George R. Aronoff ◽  
Rebecca S. Sloan ◽  
Naomi S. Fineberg
Keyword(s):  
Renal Insufficiency ◽  
Interindividual Variability ◽  
Sodium Intake ◽  
Normal Subjects

Radiochemical method for measuring plasma clearance and urinary excretion of pteroylglutamic acid.

1979 ◽  
Vol 25 (10) ◽  
pp. 1783-1786
Author(s):  
M da Costa ◽  
S P Rothenberg ◽  
Z Rosenberg
Keyword(s):  
Urinary Excretion ◽  
Plasma Clearance ◽  
Normal Subjects ◽  
Serum Folate ◽  
Metabolic Clearance ◽  
Folate Binding Protein ◽  
Radiochemical Method ◽  
Baseline Serum ◽  
Distribution Phase

Abstract A radiochemical procedure is described for specific determination of pteroylglutamate in serum and urine. This method depends on denaturation of methyltetrahydrofolate with peroxide and measurement of the residual folate by a ligand-binding radioassay. The binding determinant for the radioassay is a folate-binding protein, partially purified from chronic myelogenous lekemia cells, that has low affinity for the reduced folates and thus will preferentially measure residual pteroylglutamate rather than any nondenatured residual methyltetrahydrofolate. We used this assay to measure the clearance from plasma and the urinary excretion of pteroylglutamate and a small fraction of serum folate that is stable to this oxidation procedure. The plasma clearance after intravenous injection is characterized by an initial rapid distribution phase followed by a second, slower metabolic phase; after about 2 h all of the administered pteroylglutamate has been cleared from the blood. The peak concentration of total folate in serum 1--2 min after administration of pteroylglutamate exceeded the sum of the endogenous stable and baseline serum folate, indicating that a reduced labile folate was released from the liver and perhaps from other tissues. This reduced folate had a slower metabolic clearance rate and was excreted to some extent in urine. Only 2.3 and 7.9% of the pteroylglutamate administered to two normal subjects was excreted as stable folate.

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