Dysplastic Megakaryocytes and Eosinophilic Precursors in the Diagnosis of Myeloid Sarcoma on Lymph Node Fine-Needle Aspiration Cytology: A Case Series

2012 ◽  
Vol 56 (3) ◽  
pp. 325-329 ◽  
Author(s):  
Sandeep S. Ojha ◽  
Kanchan S. Kothari ◽  
Leena P. Naik ◽  
Gwendolyn C. Fernandes ◽  
Saaishta Rangwala ◽  
...  
1970 ◽  
Vol 7 (1) ◽  
pp. 1-5 ◽  
Author(s):  
G Shakya ◽  
S Malla ◽  
KN Shakya ◽  
R Shrestha

Background: Fine Needle Aspiration Cytology (FNAC) is a reliable and least expensive method suitable for developing countries like Nepal for the investigation of lymphadenopathy. Knowledge about the pattern of lymphadenopathy is useful in pathological reporting as well as in many clinical settings with diagnostic dilemma. This is a baseline study to investigate the pattern of cervical lymphadenopathy by lymph node FNAC in Nepalese population. Methods: A retrospective study was conducted by critically analyzing the case reports on cervical lymph node FNAC from three years' records (July 2005 to June 2008) at the National Public Health Laboratory, Teku, Kathmandu. Review of all cytological reports were done according to standard guidelines and the diagnosis was classified and correlated with patients' age and ethnicity to explore the pattern and association. Results: Of 508 cervical lymph node FNAC cases, 50.4% was reactive non-specific, 22.4% was tubercular, 4.8 % malignant, 10% chronic granulomatous and the remaining was acute suppurative (12.4%). Highest incidence of malignancy was seen in the fifth decade (50%). Whereas, tubercular lymphadenopathy was found with increasing frequency through childhood (10.5%) and adolescence (21.7%) to young adulthood (30.4%), probably indicative of waning immunity of BCG vaccination. Ethnic groups comprising of Tamang, Sherpa and Bhote had the highest incidence of malignant as well as tubercular lymphadenopathy. Conclusion: The relationship of malignant and tubercular lymphadenopthy with age and ethnicity deserves further study. Efforts at preventing tubercular and early diagnosing malignant lymphadenopathy and reducing morbidity in general will find great usefulness in such associations. Key words: Cervical Lymphadenopathy, Fine Needle Aspiration Cytology, Pattern   DOI: 10.3126/jnhrc.v7i1.2267 Journal of Nepal Health Research Council Vol. 7, No. 1, 2009 April 1-5


2015 ◽  
Vol 04 (02) ◽  
pp. 80-85
Author(s):  
Junu Devi ◽  
Kunja Lal Talukdar

Abstract Background : Fine needle aspiration cytology is a simple, quick,inexpensive and minimally invasive technique used to diagnose head and neck neoplasms commonly originated from cervical lymph node, thyroid, parotid and other salivary glands. In this study a correlation was done between cytology and histopathology whenever surgical specimens were available. Aim : To assess the frequency of various benign and malignant neoplasms in different age groups and to evaluate the sensitivity, specificity of fine needle aspiration cytology(FNAC) in head and neck neoplasms. Materials and method : The study was conducted between September 2011 to August 2013 and total 249 cases of head and neck neoplasms were analysed. Patients between 1 to 80 years were included in the study. Fine needle aspiration cytology (FNAC) diagnosis was correlated with histopathology whenever possible. Results: Out of 249 head and neck neoplasms 55.42% were from lymph node, 19.28% were from salivary gland, 14.86% were from thyroid gland, 1.20% were nasal mass, 9.24% from other sites (skin and soft tissue). M:F was 1.4:1. Most commonly affected age group was 51-60 years. Metastatic squamous cell carcinoma was most commonly encountered neoplastic lesion. Overall sensitivity, specificity oflme needle aspiration cytology(FNAC) were 97.92% and 91.67% respectively. Conclusion : Fine needle aspiration cytology is a highly sensitive, specific and has a definite role in diagnosing most of the head and neck neoplasms.


1970 ◽  
Vol 1 (2) ◽  
pp. 92-95 ◽  
Author(s):  
D Ghartimagar ◽  
A Ghosh ◽  
S Ranabhat ◽  
MK Shrestha ◽  
R Narasimhan ◽  
...  

Background: Fine needle aspiration cytology is a reliable as well as an inexpensive diagnostic method. It is suitable for the developing countries like Nepal for the diagnosis of lymphadenopathy at any approachable site. Fine needle aspiration cytology not only confirms the presence of metastatic disease but also, in most cases, gives the clue regarding the origin of the primary tumor. The aim of the study was to find out the cytological diagnosis of metastatic lymph node lesions. Materials and Methods: A combined prospective and retrospective study was done of all metastatic lymph node lesions (including both superficial and deep nodes) reported in Department of Pathology, Manipal Teaching Hospital, Pokhara from January 2005 to Deceember 2010. Results: A total of 4180 cases of fine needle aspiration cytology were carried out of which 508 cases were of lymph node. Cytology results were unsatisfactory in 58 specimens (12%), “reactive” or “infective” in 347 specimens (68%), positive for metastasis in 93 specimens (18%) and hematolymphoid malignancies include 10 cases (2%). The most common site was anterior and posterior triangles cervical nodes. The most common malignancy was adenocarcinoma, seen in 62 cases (67%), followed by metastatic squamous cells carcinoma (14 cases, 15%). Conclusion: Fine needle aspiration cytology of lymphadenoathy is a useful tool in diagnosing metastatic lesions with good certainty. Keywords: Fine needle aspiration cytology; Lymphadenopathy; Metastasis DOI: http://dx.doi.org/10.3126/jpn.v1i2.5399 JPN 2011; 1(2): 92-95


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