Multiple-Dose Up-Titration Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Selexipag, an Orally Available Selective Prostacyclin Receptor Agonist, in Healthy Subjects

Pharmacology ◽  
2014 ◽  
Vol 94 (3-4) ◽  
pp. 148-156 ◽  
Author(s):  
Shirin Bruderer ◽  
Noémie Hurst ◽  
Priska Kaufmann ◽  
Jasper Dingemanse
Keyword(s):  
Healthy Subjects ◽  
Multiple Dose ◽  
Receptor Agonist ◽  
Pharmacokinetics And Pharmacodynamics ◽  
Prostacyclin Receptor ◽  
Titration Study

scholarly journals Effect of lopinavir/ritonavir on the pharmacokinetics of selexipag an oral prostacyclin receptor agonist and its active metabolite in healthy subjects

2015 ◽  
Vol 80 (4) ◽  
pp. 670-677 ◽  
Author(s):  
Priska Kaufmann ◽  
Séverine Niglis ◽  
Shirin Bruderer ◽  
Jérôme Segrestaa ◽  
Päivi Äänismaa ◽  
...  
Keyword(s):  
Active Metabolite ◽  
Healthy Subjects ◽  
Receptor Agonist ◽  
Prostacyclin Receptor

A novel CRTH2 antagonist: Single- and multiple-dose tolerability, pharmacokinetics, and pharmacodynamics of ACT-453859 in healthy subjects

2015 ◽  
Vol 55 (7) ◽  
pp. 787-797 ◽  
Author(s):  
Martine Géhin ◽  
Daniel S. Strasser ◽  
Jochen Zisowsky ◽  
Hervé Farine ◽  
Peter M.A. Groenen ◽  
...  
Keyword(s):  
Healthy Subjects ◽  
Multiple Dose ◽  
Pharmacokinetics And Pharmacodynamics
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