Clinical Significance of First-Trimester Screening of the Retronasal Triangle for Identification of Primary Cleft Palate

2015 ◽  
Vol 38 (2) ◽  
pp. 135-141 ◽  
Author(s):  
Wei-Jing Li ◽  
Xue-Qin Wang ◽  
Rui-Ling Yan ◽  
Jing-Wen Xiang
Keyword(s):  
Three Dimensional ◽  
High Sensitivity ◽  
First Trimester ◽  
3D Ultrasound ◽  
First Trimester Screening ◽  
Term Delivery ◽  
Volumetric Images ◽  
Trimester Screening ◽  
Retronasal Triangle ◽  
Singleton Pregnancies

Objective: To investigate the use of the retronasal triangle (RNT) for identification of orofacial cleft (OC) in the first trimester and the clinical application of three-dimensional (3D) ultrasound techniques for confirming the diagnosis of OC. Methods: A total of 5,054 women with singleton pregnancies underwent first-trimester screening for Down syndrome at 11-13+6 weeks. The RNT was scanned in each fetus, and 3D volumetric images of cases with abnormal or indeterminate RNT were obtained. Results: Satisfactory images were obtained from all cases. Seven cases (1.4‰) of abnormal RNT were diagnosed as OC in the first trimester, which were confirmed at a 16 weeks scan or at a postmortem examination. One case that was considered a normal RNT was diagnosed with OC at 22+2 weeks and after term delivery. Six cases of indeterminate RNT were diagnosed as normal by 3D ultrasound. Identification of OC by visualization of the RNT in the first trimester had a sensitivity of 87.5% and a specificity of 99.9%. Conclusion: The RNT is an important sonographic landmark that has a high sensitivity and specificity for the detection of OC in the first trimester. 3D ultrasound is an important tool that aids in confirming diagnosis of OC in the first and second trimesters.

scholarly journals P06.21: Visualization of the normal and cleft fetal palate at the time of the first trimester screening using three-dimensional extended imaging

2011 ◽  
Vol 38 (S1) ◽  
pp. 189-189
Author(s):  
M. Mailath-Pokorny ◽  
A. Monteagudo ◽  
A. R. Jadhav ◽  
R. Santos ◽  
I. E. Timor-Tritsch
Keyword(s):  
Three Dimensional ◽  
First Trimester ◽  
First Trimester Screening ◽  
Trimester Screening

Aneuploidy screening during pregnancy by a three-dimensional Advanced First Trimester Screening model: Description of the AFS-3D algorithm

2012 ◽  
Vol 32 (2) ◽  
pp. 154-159
Author(s):  
Peter Schmidt ◽  
Cindy Hörmansdörfer ◽  
Bernhard Vaske ◽  
Peter Hillemanns ◽  
Alexander Scharf
Keyword(s):  
Three Dimensional ◽  
First Trimester ◽  
Model Description ◽  
First Trimester Screening ◽  
Aneuploidy Screening ◽  
Screening Model ◽  
Trimester Screening

scholarly journals Associated plasma protein during the first trimester of pregnancy and pregnancy outcomes

2018 ◽  
Vol 7 (2) ◽  
pp. 448
Author(s):  
Vennapusa Rama Devi
Keyword(s):  
Growth Retardation ◽  
Reference Range ◽  
Preterm Labour ◽  
First Trimester ◽  
Still Birth ◽  
Foetal Growth ◽  
Term Delivery ◽  
Trimester Screening ◽  
First Trimester Of Pregnancy ◽  
Singleton Pregnancies

Background: Newborns are perhaps the most vulnerable population the world over. Preterm or babies born too early, less than 37 weeks gestation, are particularly at risk. Objective of present study were to determine the strength of relationship between PAPP-A concentrations using our own reference range and rates of idiopathic preterm delivery.Methods: A retrospective cohort study was conducted on consecutive singleton pregnancies undergoing first-trimester screening for fetal Down syndrome between 11 weeks and 14 weeks of pregnancy.Results: 500 patients in first trimester of pregnancy were selected in this study. 400 patients were found to have normal levels and were followed up till delivery. 20 patients developed preterm labour. Out of 100 patients who had low PAPP-A level, 35 patients had developed preterm labour. 15 patients out of 400 normal patients developed foetal growth retardation, 13 out of 100 low patients had foetal growth retardation. 5 out 400 normal patients developed PIH and no still birth was seen in normal patients. 15 out of 100 low patients had PIH and 2 patients had still birth. Most of the patients had asymmetrical FGR which concludes that there might be increased utero-placental resistance because of foetal growth restriction.Conclusions: In the first trimester of pregnancy, PPP-A level is an important predictor of outcome of obstetrics. A low level of PAPP-A is useful in indicating the risk of pre-term delivery and chance of PIH development.

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