Enzyme Studies in Experimental Leukemia

AbstractThe quantum chemical calculations using DFT were performed for 2-alkyl-4X and 2,6-dialkyl-4-X substituted phenols. Based on the optimal geometries the bond dissociation enthalpies (BDEs), proton enthalpies (PAs) and the lipophilicities were computed. Additionally, simple geometry parameter was found correlating well with experimental leukemia cell toxicity of substituted phenols. Next, we have found no linear dependence between PA or BDE values and log1/C values in gas phase or in water despite the radical toxicity mechanism proposed in the literature.

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Oxidation of 2-amino-9-β-d-ribofurnosylpurine-6-sulfenamide to the corresponding 6-sulfonamide facilitates changes in biologic characterization that include activity against thiopurine-refractory experimental leukemia

Cancer Letters ◽

10.1016/0304-3835(90)90180-6 ◽

1990 ◽

Vol 50 (1) ◽

pp. 63-70 ◽

Cited By ~ 1

Author(s):

R.A. Finch ◽

K.M. Vasquez ◽

N.B. Hanna ◽

G.R. Revankar ◽

R.K. Robins ◽

...

Keyword(s):

Experimental Leukemia ◽

Biologic Characterization

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Stem Cells and Experimental Leukemia Can Be Distinguished by Lipid Raft Protein Composition

Stem Cells and Development ◽

10.1089/scd.2006.15.677 ◽

2006 ◽

Vol 15 (5) ◽

pp. 677-686 ◽

Cited By ~ 10

Author(s):

Anja Osterhues ◽

Sibylle Liebmann ◽

Monika Schmid ◽

Deborah Buk ◽

Ralf Huss ◽

...

Keyword(s):

Stem Cells ◽

Lipid Raft ◽

Protein Composition ◽

Experimental Leukemia

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Liver Mitochondrial Enzyme System In The Dynamics Of Experimental Leukemia

European Medical Health and Pharmaceutical Journal ◽

10.12955/emhpj.v4i0.361 ◽

2012 ◽

Vol 4 ◽

Author(s):

Gulmira Kasymova ◽

Ulugbek Zaribbaev

Keyword(s):

Lipid Peroxidation ◽

Respiratory Chain ◽

Enzyme System ◽

Mitochondrial Enzymes ◽

Mitochondrial Enzyme ◽

Antioxidant Protection ◽

Complex Iv ◽

Experimental Leukemia

In rats with leukemia activity of liver mitochondrial enzymes are decreased at 6 months. Later, we noted compensatory activation of complexes II and III of the respiratory chain and transition to decompensation stage by final deadline. The activity of complex IV of the respiratory chain remains high. These changes result from increased lipid peroxidation and decreased activity of antioxidant protection enzymes.

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