Multicenter Clinical Trials: Methodological Aspects

2015 ◽  
pp. 9-20
Author(s):  
T. A. Ban ◽  
W. H. Wilson
Keyword(s):  
Clinical Trials ◽  
Multicenter Clinical Trials ◽  
Methodological Aspects

Registry of Multicenter Clinical Trials: Twelfth and Thirteenth Report – 1990–1991

1992 ◽  
Vol 68 (06) ◽  
pp. 752-778 ◽  
Author(s):  
J P Boissel ◽  
N Bossard
Keyword(s):  
Clinical Trials ◽  
Multicenter Clinical Trials

Clinical Trials Update

2009 ◽  
Vol 8 (2) ◽  
pp. 99-99
Keyword(s):  
Clinical Trials ◽  
Pulmonary Hypertension ◽  
Preliminary Results ◽  
Multicenter Clinical Trials

We would like to introduce you to a new section in Advances in Pulmonary Hypertension in which we highlight results from ongoing and recent clinical trials. The preliminary results of several multicenter clinical trials have recently been presented. In this issue, we will focus on the results of Freedom-C, which was presented in November of 2008, as well as the Walk-PHaSST study, which was stopped early in July 2009.

scholarly journals Enumeration of Major Peripheral Blood Leukocyte Populations for Multicenter Clinical Trials Using a Whole Blood Phenotyping Assay

10.3791/4302 ◽  
2012 ◽  
Author(s):  
Tiffany R. Hensley ◽  
Austin B. Easter ◽  
Sarah E. Gerdts ◽  
Stephen C. De Rosa ◽  
Antje Heit ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Whole Blood ◽  
Peripheral Blood ◽  
Peripheral Blood Leukocyte ◽  
Multicenter Clinical Trials ◽  
Blood Leukocyte ◽  
Leukocyte Populations

scholarly journals Comparison of functional outcomes from orthopedic and neurosurgical interventions in spastic diplegia

1998 ◽  
Vol 4 (1) ◽  
pp. E5 ◽  
Author(s):  
Mark F. Abel ◽  
Diane L. Damiano ◽  
John F. McLaughlin ◽  
Kit M. Song ◽  
Catherine S. Graubert ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Motor Function ◽  
Three Dimensional ◽  
Gait Velocity ◽  
Spastic Diplegia ◽  
Five Dimensions ◽  
Dorsal Rhizotomy ◽  
Multicenter Clinical Trials ◽  
Functional Outcome Measures ◽  
Post Hoc

Selective dorsal rhizotomy (SDR) and orthopedic surgery, in the form of muscle-tendon (MT) lengthening surgery are commonly performed in ambulatory children with spastic diplegia to improve their level of motor function. This investigation is a post hoc comparison of the functional effects from each of these surgical options in 30 patients with spastic diplegia who underwent one of these interventions as their initial surgical procedure. Sixteen children underwent SDR and 14 underwent MT surgery in two separate prospective clinical trials. The same functional outcome measures preoperatively and approximately 1 year postoperatively were used in both studies including temporospatial parameters from three-dimensional gait analysis, the total score, and score on each of the five dimensions of the Gross Motor Function Measure (GMFM). Comparisons indicate that patients who underwent SDR had significant improvements in GMFM Dimensions 2, 4, and 5 as well as in total score, although 63% of those studied had a 10% or more reduction in gait velocity. Gait was more predictably improved in the MT group, with only 21% demonstrating reductions in velocity. Conversely, the change in GMFM scores in the MT group was not as pervasive and skewed toward higher skills with only GMFM Dimension 5 and total score improved significantly. Several important hypotheses are derived from these comparisons. Multicenter clinical trials are needed to define more clearly the indications for and to assess more comprehensively the outcomes from each intervention.

scholarly journals Harmonization of laboratory results by data adjustment in multicenter clinical trials

2018 ◽  
Vol 33 (6) ◽  
pp. 1119-1128
Author(s):  
Sang Gon Lee ◽  
Hee-Jung Chung ◽  
Jeong Bae Park ◽  
Hyosoon Park ◽  
Eun Hee Lee
Keyword(s):  
Clinical Trials ◽  
Laboratory Results ◽  
Multicenter Clinical Trials ◽  
Data Adjustment

Biochemical efficacy of long-acting lanreotide depot/Autogel in patients with acromegaly naïve to somatostatin-receptor ligands: analysis of three multicenter clinical trials

Pituitary ◽  
2018 ◽  
Vol 21 (3) ◽  
pp. 283-289 ◽  
Author(s):  
Hussain Alquraini ◽  
Maria del Pilar Schneider ◽  
Beloo Mirakhur ◽  
Ariel Barkan
Keyword(s):  
Clinical Trials ◽  
Somatostatin Receptor ◽  
Receptor Ligands ◽  
Somatostatin Receptor Ligands ◽  
Multicenter Clinical Trials ◽  
Long Acting

Spectrofluorimetric assessment of plasma dipyridamole stability: Sample storage for multicenter clinical trials?

2008 ◽  
Vol 123 (1) ◽  
pp. 184-186 ◽  
Author(s):  
Victor Serebruany ◽  
Ilya Pokov ◽  
Dan Hanley
Keyword(s):  
Clinical Trials ◽  
Sample Storage ◽  
Multicenter Clinical Trials
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