Clinical Application of 7T Magnetic Resonance Imaging in Patients with Focal Cortical Dysplasia IIa and Epilepsy

2020 ◽  
pp. 1-9
Author(s):  
Tinghong Liu ◽  
Huilou Liang ◽  
Jianfei Cui ◽  
Kaibao Sun ◽  
Shaohui Zhang ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
White Matter ◽  
Magnetic Resonance ◽  
Focal Cortical Dysplasia ◽  
Cortical Dysplasia ◽  
Preoperative Imaging ◽  
Seizure Freedom ◽  
Resonance Imaging ◽  
3T Mri ◽  
Strength Grade

<b><i>Background:</i></b> Focal cortical dysplasia (FCD) is one of the most important pathogenic findings in patients with extratemporal lobe epilepsy. Magnetic resonance imaging (MRI)-negative is the most important negative factor to predict postoperative seizure freedom; however, FCD-I and part of FCD-IIa are MRI-negative on routine MRI. <b><i>Objectives:</i></b> To explore the diagnostic values of 7T MRI and its new scan sequences in epilepsy patients with FCD-IIa. <b><i>Methods:</i></b> To include patients with focal seizure and suspicious focal abnormal imaging on 3T MRI during preoperative evaluation and perform a 7T MRI scan with white matter-suppressed (WMS) and gray-white matter tissue border enhancement (GWBE) sequences, resective epilepsy surgery, and postoperative pathological finding of FCD-IIa. The preoperative qualitative and localization significance of 7T MRI and 3T MRI in lesions with FCD-IIa was compared, and then, the imaging characteristics of lesions with FCD-IIa on 7T MRI were analyzed. <b><i>Results:</i></b> Ten cases were enrolled in this study. Seven tesla MRI presented high spatial resolutions and a high signal-to-noise ratio. WMS and GWBE could selectively suppress the signal of special tissue and improved the possibility of FCD findings. FCD-IIa showed abnormal thickness of gray matter and a blurring border and was hypointense on 7T MRI compared with 3T MRI. Seven patients showed improvement in the qualitative diagnosis strength grade of FCD, and 6 subjects showed improvement in the localization strength grade of the lesion border after careful reading of the 7T MR images. Significant differences were found in the qualitative diagnosis of FCD (<i>p</i> &#x3c; 0.05) and localization of the lesion border (<i>p</i> &#x3c; 0.05) between the neuroimaging diagnoses based on 3T MRI and the findings based on 7T MRI. <b><i>Conclusion:</i></b> 7T MRI with WMS and GWBE sequences shows application value in the preoperative imaging diagnosis of lesions with FCD-IIa in epilepsy patients.

scholarly journals Coregistrating magnetic source and magnetic resonance imaging for epilepsy surgery in focal cortical dysplasia

2018 ◽  
Vol 19 ◽  
pp. 487-496 ◽  
Author(s):  
Burkhard S. Kasper ◽  
Karl Rössler ◽  
Hajo M. Hamer ◽  
Arnd Dörfler ◽  
Ingmar Blümcke ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Epilepsy Surgery ◽  
Focal Cortical Dysplasia ◽  
Cortical Dysplasia ◽  
Resonance Imaging ◽  
Magnetic Source

Double Inversion Recovery Magnetic Resonance Imaging in Identifying Focal Cortical Dysplasia

2016 ◽  
Vol 61 ◽  
pp. 87-93 ◽  
Author(s):  
Lily C. Wong-Kisiel ◽  
Jeffrey W. Britton ◽  
Robert J. Witte ◽  
Kristen M. Kelly-Williams ◽  
Amy L. Kotsenas ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Focal Cortical Dysplasia ◽  
Cortical Dysplasia ◽  
Inversion Recovery ◽  
Double Inversion Recovery ◽  
Resonance Imaging

Focal Cortical Dysplasia: Improving Diagnosis and Localization With Magnetic Resonance Imaging Multiplanar and Curvilinear Reconstruction

2002 ◽  
Vol 12 (3) ◽  
pp. 224-230 ◽  
Author(s):  
Maria Augusta Montenegro ◽  
Li Li ◽  
Marilisa M. Guerreiro ◽  
Carlos A. M. Guerreiro ◽  
Fernando Cendes
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Focal Cortical Dysplasia ◽  
Cortical Dysplasia ◽  
Resonance Imaging

Subclinical Abnormal Gyration Pattern, a Potential Anatomic Marker of Epileptogenic Zone in Patients With Magnetic Resonance Imaging–Negative Frontal Lobe Epilepsy

Neurosurgery ◽  
2011 ◽  
Vol 69 (1) ◽  
pp. 80-94 ◽  
Author(s):  
Jean Régis ◽  
Manabu Tamura ◽  
Michael C Park ◽  
Aileen McGonigal ◽  
Denis Rivière ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Frontal Lobe ◽  
Focal Cortical Dysplasia ◽  
Cortical Dysplasia ◽  
Frontal Lobe Epilepsy ◽  
Potential Contribution ◽  
Epileptogenic Zone ◽  
Resonance Imaging

Abstract BACKGROUND: Epilepsy surgery for magnetic resonance imaging (MRI)-negative patients has a less favorable outcome. OBJECTIVE: Detection of subclinical abnormal gyration (SAG) patterns and their potential contribution to assessment of the topography of the epileptogenic zone (EZ) is addressed in MRI-negative patients with frontal lobe epilepsy. METHODS: Between September 1998 and July 2005, 12 MRI-negative frontal lobe epilepsy patients underwent stereoelectroencephalography with postcorticectomy follow-up of longer than 1 year (average, 3.3 years). Original software (BrainVISA/Anatomist, http://brainvisa.info) trained on a database of normal volunteers was used to determine which sulci had morphology out of the normal range (SAG). Topography of the EZ, SAG pattern, corticectomy, postoperative seizure control, and histopathology were analyzed. RESULTS: At last follow-up, 8 of 12 patients (66.7%) were Engel class I (7 IA and 1 IB), 2 class II, and 2 class IV. Small focal cortical dysplasia was histologically diagnosed in 9 of the 12 patients (75%), including 7 of 8 seizure-free patients (87.5%). A SAG pattern was found to be in the EZ area in 9 patients (75%), in the ipsilateral frontal lobe out of the EZ in 2, and limited to the contralateral hemisphere in 1. CONCLUSION: SAG patterns appear to be associated with the topography of the EZ in MRI-negative frontal lobe epilepsy and may have a useful role in preoperative assessment. Small focal cortical dysplasia not detected with MRI is often found on histopathological examination, particularly in the depth of the posterior part of the superior frontal sulcus and intermediate frontal sulcus, suggesting a specific developmental critical zone in these locations.

Focal cortical dysplasia on magnetic resonance imaging: A case report

1988 ◽  
Vol 12 (1) ◽  
pp. 61-63 ◽  
Author(s):  
Martha A. Nowell ◽  
Robert I. Grossman ◽  
Roger Packer ◽  
David B. Hackney ◽  
Herbert I. Goldberg ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Case Report ◽  
Magnetic Resonance ◽  
Focal Cortical Dysplasia ◽  
Cortical Dysplasia ◽  
Resonance Imaging

Endfolium sclerosis in temporal lobe epilepsy diagnosed preoperatively by 3-tesla magnetic resonance imaging

2009 ◽  
Vol 110 (6) ◽  
pp. 1124-1126 ◽  
Author(s):  
Masaki Iwasaki ◽  
Nobukazu Nakasato ◽  
Hiroyoshi Suzuki ◽  
Teiji Tominaga
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Temporal Lobectomy ◽  
Preoperative Imaging ◽  
Seizure Freedom ◽  
Resonance Imaging ◽  
Anterior Temporal Lobectomy ◽  
The Right

A 34-year-old man presented with intractable temporal lobe epilepsy. Three-tesla magnetic resonance imaging revealed increased T2 signal intensity and volume loss limited to the CA4 region of the right hippocampus. A right anterior temporal lobectomy and amygdalohippocampectomy were performed. Histological examination of the hippocampus disclosed severe neuron loss limited to the CA4 region, consistent with the preoperative imaging, which is a pattern known as endfolium sclerosis. Close inspection of the internal hippocampal anatomy with high-field MR imaging is useful in patients with temporal lobe epilepsy, because endfolium sclerosis may be associated with less chance of seizure freedom after temporal lobectomy.

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