scholarly journals Natural History of Rheumatic Aortic Regurgitation

Circulation ◽  
1971 ◽  
Vol 44 (3) ◽  
pp. 368-380 ◽  
Author(s):  
MARIO SPAGNUOLO ◽  
HOWARD KLOTH ◽  
ANGELO TARANTA ◽  
EUGENIE DOYLE ◽  
BERNARD PASTERNACK
Keyword(s):  
Natural History ◽  
Aortic Regurgitation ◽  
History Of

scholarly journals The natural history of rheumatic aortic regurgitation and the indications for surgery.

Heart ◽  
1976 ◽  
Vol 38 (2) ◽  
pp. 147-154 ◽  
Author(s):  
H J Smith ◽  
J M Neutze ◽  
A H Roche ◽  
T M Agnew ◽  
B G Barratt-Boyes
Keyword(s):  
Natural History ◽  
Aortic Regurgitation ◽  
Indications For Surgery ◽  
History Of

l-Arginine Can Enhance the Beneficial Effect of Losartan in Patients with Chronic Aortic Regurgitation and Isolated Systolic Hypertension

2021 ◽  
Author(s):  
Shoa-Lin Lin ◽  
Mike Lin ◽  
Kuei-Liang Wang ◽  
Hsien-Wen Kuo ◽  
Tahir Tak
Keyword(s):  
Blood Pressure ◽  
Natural History ◽  
Beneficial Effect ◽  
Aortic Regurgitation ◽  
Systolic Hypertension ◽  
Exercise Duration ◽  
Volume Index ◽  
Isolated Systolic Hypertension ◽  
History Of ◽  
Chronic Aortic Regurgitation

Abstract Background Information about the effects of angiotensin II receptor blocker (ARB) therapy on the hemodynamic and cardiac structure in patients with chronic aortic regurgitation (CAR) and isolated systolic hypertension (ISH) is limited. Objectives This study planned to test the hypothesis that l-arginine could further enhance the beneficial effect of an ARB, losartan, and provide a favorable effect on the natural history of CAR and ISH. Methods Sixty patients with CAR and ISH were enrolled in a randomized, double-blind trial comparing hemodynamic and ultrasonic change in two treatment arms: losartan + l-arginine and losartan-only treated groups. Serial echocardiographic and hemodynamic studies were evaluated before and after treatment. Results Both groups had a significant reduction in systolic blood pressure (SBP) and diastolic blood pressure (DBP), left ventricular end-diastolic volume index (LVEDVI), LV end-systolic volume index (LVESVI), LV mass index (LVMI), and LV mean wall stress after 6- and 12-month treatment (p <0.01 in all comparisons). Both groups had a significant increase in LV ejection fraction and exercise duration after 6- and 12-month treatment (p < 0.01 in all comparisons). Using multivariate linear regression analysis, only losartan + l-arginine therapy achieved a significantly lower LVESVI (38.89 ± 0.23 mL/m2), LVEDVI (102.3 ± 0.3 mL/m2), LVMI (107.6 ± 0.3 g/m2), SBP (123.5 ± 1.0 mm Hg), and greater exercise duration (7.38 ± 0.02 minutes) than those of the losartan-only treated groups (p <0.01 in all comparisons). Conclusions These findings suggest that early co-administrative strategy provides a beneficial approach to favorably influence the natural history of CAR.

The natural history of aortic regurgitation

1973 ◽  
Vol 54 (5) ◽  
pp. 577-588 ◽  
Author(s):  
Nora Goldschlager ◽  
James Pfeifer ◽  
Keith Cohn ◽  
Robert Popper ◽  
Arthur Selzer
Keyword(s):  
Natural History ◽  
Aortic Regurgitation ◽  
History Of

Abstract 2658: Does Aortic Valve Morphology Influence The Natural History Of Aortic Regurgitation?

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
Joan Alguersuari ◽  
Antonia Sambola ◽  
Pilar Tornos ◽  
Arturo Evangelista
Keyword(s):  
Aortic Valve ◽  
Natural History ◽  
Aortic Regurgitation ◽  
Wall Stress ◽  
Left Ventricular ◽  
Regurgitant Fraction ◽  
History Of ◽  
The Impact ◽  
Ascending Aortic Diameter

BACKROUND: The influence of the morphology of aortic valve on the natural history of aortic regurgitation (AR) is uncertain. OBJECTIVE: To assess the natural history of AR in patients with bicuspid aortic valve (BAV) comparing with tricuspid aortic valve (TAV). METHODS AND RESULTS: Ninety-five patients with asymptomatic severe chronic AR were prospectively studied. Follow-up period was 7+/- 2 years. Forty-one patients (42%) had BAV and were significantly younger than patients with TAV (39 +/- 11 vs 47 +/- 14 years, p=0.001). Mean ascending aortic diameter (AAD) was significantly larger in BAV (42 +/- 7 vs 37 +/- 5 mm, p=0.0001). Differences in AAD persisted until the end of the follow-up (47 +/- 6 vs 40 +/-5 mm, p=0.0001). The percentatge of increase in AAD was 12 +/- 5% in BAV and 8 +/- 5% in TAV with yearly increase of 0.83 mm in BAV and 0.42 mm in TAV. The changes in left ventricle diameters, mass index, wall stress, regurgitant fraction and ejection fraction were similar in BAV and TAV. Patients with BAV did not need surgery earlier due to AR than patients with TAV (4.7 +/- 2 vs 4.8 +/- 3 years). At 5 years follow-up 11 patients with BAV (27%) and 10 patients with TAV (23%) needed surgery. CONCLUSIONS: Patients with BAV are younger, had a larger AAD and a higher rate of AAD enlargement than patients with TAV. The morphology of the aortic valve (BAV vs TAV) had no infuence in the progression of AR and the impact on left ventricular function.

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