Evaluation of ventricular systolic function and cavity dimensions is an essential part of the echocardiographic examination. Treatment strategy and decisionmaking for a patient’s condition is affected by systolic function. Echocardiography plays a major in monitoring the effects of therapy. Appropriate knowledge about how to assess left ventricular size, shape and function is thus crucial. This chapter demonstrates left chamber quantification through various measurements of left ventricular size and dimensions, left ventricular mass, left ventricularglobal function, regional wall motion, left ventricular segmentation, global left ventricular remodelling, and left atrial measurements. Techniques, advantages, and limitations of different methods and echocardiographic examinations are given throughout.