scholarly journals Ultrastructural evidence of microvascular damage and myocardial cell injury after coronary artery occlusion: which comes first?

Circulation ◽  
1980 ◽  
Vol 62 (5) ◽  
pp. 945-952 ◽  
Author(s):  
R A Kloner ◽  
R E Rude ◽  
N Carlson ◽  
P R Maroko ◽  
L W DeBoer ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Cell Injury ◽  
Coronary Artery Occlusion ◽  
Myocardial Cell ◽  
Artery Occlusion ◽  
Microvascular Damage ◽  
Ultrastructural Evidence ◽  
Myocardial Cell Injury

Ultrastructural Pathology of Ischemic Myocardium as Revealed by the Freeze Fracture Technique

1975 ◽  
Vol 33 ◽  
pp. 426-427
Author(s):  
M. Ashraf ◽  
W. Mayr
Keyword(s):  
Coronary Artery ◽  
Cell Injury ◽  
Freeze Fracture ◽  
Coronary Artery Occlusion ◽  
Myocardial Cell ◽  
Artery Occlusion ◽  
Ischemic Myocardium ◽  
Ultrastructural Changes ◽  
Acute Ischemia ◽  
Thin Sections

Myocardial cells undergo extensive ultrastructural changes during ischemia, easily observed after 30 minutes of coronary artery occlusion. Although various membranous organelles remain intact during acute ischemia, biochemical evidence indicates several metabolic alterations in affected cells. Since cell membranes and membranes of intracellular organelles play an important role in the pathogenesis of myocardial cell injury, changes in their interiors could be informative. However, such changes are not easily detectable in conventional thin sections. This study examined ultrastructural alterations in the membranous organelles of ischemic myocardium using the freeze-fracture technique to improve detection of such changes.After 5 and 24 hours of coronary artery occlusion the hearts from dogs and rats were perfused with buffered glutaraldehyde. Small pieces of the left ventricle were dipped in Freon 22 and immediately frozen in liquid nitrogen before fracturing in a Balzer's freeze-etch apparatus at -100 or -120°C.

Influence of Ischemic Preconditioning on Lethal Cell Injury after Coronary Artery Occlusion

1994 ◽  
Vol 24 (4) ◽  
pp. 572
Author(s):  
Kyu Hyung Ryu ◽  
Myoung Mook Lee ◽  
Yung Lee ◽  
June Soo Kim ◽  
Jung Don Seo ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Ischemic Preconditioning ◽  
Cell Injury ◽  
Coronary Artery Occlusion ◽  
Artery Occlusion

Changes in Hemodynamics and Bradykinin Concentration in Coronary Sinus Blood in Experimental Coronary Artery Occlusion

1977 ◽  
Vol 18 (5) ◽  
pp. 679-689 ◽  
Author(s):  
Keiichi HASHIMOTO ◽  
Masaru HIROSE ◽  
Soichi FURUKAWA ◽  
Hirokazu HAYAKAWA ◽  
Eiichi KIMURA
Keyword(s):  
Coronary Artery ◽  
Coronary Sinus ◽  
Coronary Artery Occlusion ◽  
Artery Occlusion ◽  
Coronary Sinus Blood

Some Problems Concerning Coronary Artery Occlusion and Acute Myocardial Infarction

Circulation ◽  
1969 ◽  
Vol 40 (5s4) ◽  
Author(s):  
DONALD B. HACKEL ◽  
E. HARVEY ESTES ◽  
ABE WALSTON ◽  
STEPHEN KOFF ◽  
EUGENE DAY
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Coronary Artery ◽  
Coronary Artery Occlusion ◽  
Artery Occlusion

Arrhythmias and Death After Coronary Artery Occlusion in the Rat

Circulation ◽  
1995 ◽  
Vol 92 (2) ◽  
pp. 253-261 ◽  
Author(s):  
Christian F. Opitz ◽  
Gary F. Mitchell ◽  
Marc A. Pfeffer ◽  
Janice M. Pfeffer
Keyword(s):  
Coronary Artery ◽  
Coronary Artery Occlusion ◽  
Artery Occlusion

Changes in Myocardial Electrical Impedance Induced by Coronary Artery Occlusion in Pigs With and Without Preconditioning

Circulation ◽  
1997 ◽  
Vol 96 (9) ◽  
pp. 3079-3086 ◽  
Author(s):  
Juan Cinca ◽  
Mark Warren ◽  
Ana Carreño ◽  
Màrius Tresànchez ◽  
Lluís Armadans ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Electrical Impedance ◽  
Coronary Artery Occlusion ◽  
Artery Occlusion

Mechanical Unloading Properties of Axial Flow Pumps and their Effect on Myocardial Stunning

1995 ◽  
Vol 18 (12) ◽  
pp. 766-771 ◽  
Author(s):  
F. R. Waldenberger ◽  
B. Meyns ◽  
P. Wouters ◽  
E. De Ruyter ◽  
E. Pongo ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Myocardial Stunning ◽  
Myocardial Dysfunction ◽  
Axial Flow ◽  
Coronary Artery Occlusion ◽  
Artery Occlusion ◽  
Wall Thickening ◽  
Myocardial Wall Motion ◽  
Mechanical Unloading ◽  
Artery Disease

Postischemic myocardial dysfunction affects morbidity and mortality in patients with coronary artery disease. It is known that mechanical unloading of the left heart ventricle can positively influence postischemic myocardial dysfunction. In this respect we tested two miniaturised axial flow pumps, i.e. the 14-F and the 21-F Hemopump®. An experimental study was carried out on 30 open chest sheep where regional myocardial wall motion was followed using sonomicrometry in a preparation of transient coronary artery occlusion. Only the larger 21-F Hemopump® showed hemodynamically significant unloading of the left ventricle. Furthermore, as far as stunning is concerned, systolic wall thickening recovered better when this type of pump was used during reperfusion. Also postejection thickening, which is an indication of diastolic postischemic dysfunction, is reduced significantly in the postischemic area (ANOVA, p<0.05). Thus, the 21F Hemopump®, but not the 14F Hemopump®, provides adequate mechanical unloading in order to beneficially influence myocardial stunning.

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