Inotropic Effects of Glyceryl Trinitrate and Spontaneous NO Donors in the Dog Heart

Circulation ◽  
1997 ◽  
Vol 96 (8) ◽  
pp. 2675-2682 ◽  
Author(s):  
Benedikt Preckel ◽  
Georg Kojda ◽  
Wolfgang Schlack ◽  
Dirk Ebel ◽  
Karin Kottenberg ◽  
...  
Keyword(s):  
Glyceryl Trinitrate ◽  
Inotropic Effects ◽  
No Donors ◽  
Dog Heart

scholarly journals Chronotropic and inotropic effects of captopril on the dog heart.

1983 ◽  
Vol 24 (2) ◽  
pp. 269-275 ◽  
Author(s):  
Shigetoshi CHIBA ◽  
Hidehiko WATANABE ◽  
Miyoharu KOBAYASHI
Keyword(s):  
Inotropic Effects ◽  
Dog Heart

scholarly journals Different Chronotropic and Inotropic Effects of EMD 57033 and EMD 53998, Ca2+ Sensitizers, on Isolated, Blood-Perfused Dog Heart Preparations

1998 ◽  
Vol 76 (4) ◽  
pp. 435-439 ◽  
Author(s):  
Manoj Lakhe ◽  
Yasuyuki Furukawa ◽  
Takanori Yonezawa ◽  
Masamichi Hirose ◽  
Yoshito Nagashima ◽  
...  
Keyword(s):  
Inotropic Effects ◽  
Dog Heart ◽  
Emd 53998

Effect of in vivo nitrate tolerance on hypersensitivity to NO donors after NO-synthase blockade

2002 ◽  
Vol 80 (11) ◽  
pp. 1106-1118 ◽  
Author(s):  
Jodan D Ratz ◽  
Michael A Adams ◽  
Brian M Bennett
Keyword(s):  
Nitric Oxide ◽  
Glyceryl Trinitrate ◽  
Nitrate Tolerance ◽  
Metabolite Formation ◽  
No Donor ◽  
No Donors ◽  
Nos Inhibitors ◽  
Pressure Lowering ◽  
Oxide Synthase

Animals treated with nitric oxide synthase (NOS) inhibitors exhibit marked hypersensitivity to the blood pressure lowering effects of exogenous nitric oxide (NO) donors. We used this model as a sensitive index to evaluate the relative importance of reduced biotransformation of glyceryl trinitrate (GTN) to NO in the development of nitrate tolerance. NOS-blockade hypertension using NG-nitro-L-arginine methyl ester (L-NAME) caused a marked enhancement of the mean arterial pressure (MAP) decrease mediated by GTN in nontolerant rats. However, even large doses of GTN were unable to change the MAP in GTN-tolerant, NOS-blockade hypertensive animals. In contrast, the MAP responses to the spontaneous NO donor sodium nitroprusside (SNP) were completely unaltered in either tolerant rats or tolerant NOS-blockade hypertensive animals, indicating that NO-dependent vasodilatory mechanisms remain intact despite the development of GTN tolerance. The MAP-lowering effects of GTN in NOS-blockade hypertensive animals were restored 48 h after cessation of chronic GTN exposure. These alterations in the pharmacodynamic response to GTN during tolerance development and reversal were associated with parallel changes in the pattern of GTN metabolite formation, suggesting that the activity of one or more enzymes involved in nitrate metabolism was altered as a consequence of chronic GTN exposure. These findings suggest that the vasodilation resulting from the vascular biotransformation of GTN to NO (or a closely related species) is severely compromised in nitrate-tolerant animals, and that although other mechanisms may contribute to the vascular changes observed following the development of GTN tolerance, decreased GTN bioactivation is likely the most important.Key words: biotransformation, glyceryl trinitrate, hypertension, nitric oxide, tolerance.

Positive chronotropic and inotropic effects of angiotension II in the dog heart

1978 ◽  
Vol 50 (1) ◽  
pp. 17-25 ◽  
Author(s):  
Miyoharu Kobayashi ◽  
Yasuyuki Furukawa ◽  
Shigetoshi Chiba
Keyword(s):  
Inotropic Effects ◽  
Dog Heart ◽  
Angiotension Ii

scholarly journals Positive and negative inotropic effects of NO donors in atrial and ventricular fibres of the frog heart

1999 ◽  
Vol 518 (2) ◽  
pp. 449-461 ◽  
Author(s):  
Jean-Michel Chesnais ◽  
Rodolphe Fischmeister ◽  
Pierre-François Méry
Keyword(s):  
Frog Heart ◽  
Inotropic Effects ◽  
No Donors ◽  
Negative Inotropic Effects

scholarly journals Chronotropic, dromotropic and inotropic effects of dilazep in the intact dog heart and isolated atrial preparation.

1984 ◽  
Vol 25 (5) ◽  
pp. 793-803
Author(s):  
Shigetoshi CHIBA ◽  
Miyoharu KOBAYASHI ◽  
Masahiro SHIMOTORI ◽  
Yasuyuki FURUKAWA ◽  
Kimiaki SAEGUSA
Keyword(s):  
Inotropic Effects ◽  
Dog Heart

scholarly journals Effect of Treatment Delay, Stroke Type, and Thrombolysis on the Effect of Glyceryl Trinitrate, a Nitric Oxide Donor, on Outcome after Acute Stroke: A Systematic Review and Meta-Analysis of Individual Patient from Randomised Trials

2016 ◽  
Vol 2016 ◽  
pp. 1-12 ◽  
Author(s):  
Philip M. Bath ◽  
Lisa Woodhouse ◽  
Kailash Krishnan ◽  
Craig Anderson ◽  
Eivind Berge ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Glyceryl Trinitrate ◽  
Acute Stroke ◽  
Meta Analysis ◽  
Haemorrhagic Stroke ◽  
Stroke Onset ◽  
Nitric Oxide Donor ◽  
No Donor ◽  
No Donors ◽  
Subacute Stroke

Background.Nitric oxide (NO) donors are a candidate treatment for acute stroke and two trials have suggested that they might improve outcome if administered within 4–6 hours of stroke onset. We assessed the safety and efficacy of NO donors using individual patient data (IPD) from completed trials.Methods.Randomised controlled trials of NO donors in patients with acute or subacute stroke were identified and IPD sought from the trialists. The effect of NO donor versus control on functional outcome was assessed using the modified Rankin scale (mRS) and death, by time to randomisation. Secondary outcomes included measures of disability, mood, and quality of life.Results.Five trials (4,197 participants) were identified, all involving glyceryl trinitrate (GTN). Compared with control, GTN lowered blood pressure by 7.4/3.3 mmHg. At day 90, GTN did not alter any clinical measures. However, in 312 patients randomised within 6 hours of stroke onset, GTN was associated with beneficial shifts in the mRS (odds ratio (OR) 0.52, 95% confidence interval (CI) 0.34–0.78) and reduced death (OR 0.32, 95% CI 0.14–0.78).Conclusions.NO donors do not alter outcome in patients with recent stroke. However, when administered within 6 hours, NO donors might improve outcomes in both ischaemic and haemorrhagic stroke.

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