scholarly journals Suppression of calcific fibrous-fatty plaque formation in rabbits by agents not affecting elevated serum cholesterol levels. The effect of thiophene compounds.

1978 ◽  
Vol 43 (1) ◽  
pp. 115-125 ◽  
Author(s):  
C T Chan ◽  
H Wells ◽  
D M Kramsch
Keyword(s):  
Serum Cholesterol ◽  
Elevated Serum ◽  
Plaque Formation ◽  
Cholesterol Levels ◽  
Elevated Serum Cholesterol ◽  
Fatty Plaque

Reduced atherosclerosis in MyD88-null mice links elevated serum cholesterol levels to activation of innate immunity signaling pathways

2004 ◽  
Vol 10 (4) ◽  
pp. 416-421 ◽  
Author(s):  
Harry Björkbacka ◽  
Vidya V Kunjathoor ◽  
Kathryn J Moore ◽  
Stephanie Koehn ◽  
Christine M Ordija ◽  
...  
Keyword(s):  
Innate Immunity ◽  
Signaling Pathways ◽  
Serum Cholesterol ◽  
Elevated Serum ◽  
Cholesterol Levels ◽  
Elevated Serum Cholesterol

PYRIDOXINE DEFICIENCY AND CHOLESTEROGENESIS IN THE CHICK

1964 ◽  
Vol 42 (8) ◽  
pp. 1161-1168 ◽  
Author(s):  
P. J. Lupien ◽  
B. B. Migicovsky
Keyword(s):  
Serum Cholesterol ◽  
Elevated Serum ◽  
Normal Serum ◽  
Liver Cholesterol ◽  
Acetate Incorporation ◽  
Deficient Diet ◽  
Pyridoxine Deficiency ◽  
Cholesterol Levels ◽  
Normal States ◽  
Elevated Serum Cholesterol

Physiological disturbances common to B6 avitaminosis were clearly manifested when 3-day-old chicks were fed a pyridoxine-deficient diet for 8 days. Body and liver weights were depressed but were restored to quasi-normal states after 4 days of pyridoxine supplementation (3 mg/lb diet). The elevated serum cholesterol levels observed were the result of a failure of this parameter to fall at the rate characteristic of a well-fed bird and not to a specific elevation of the serum cholesterol above the starting conditions. Liver cholesterol levels were unaffected by the hypovitaminosis. Pyridoxine supplementation rapidly re-established normal serum cholesterol levels.The significant depression of C14-acetate incorporation into liver and serum cholesterol of 7-day-old pyridoxine-deficient chicks was maintained for the next 8 days. Mevalonate-2-C14 incorporation into liver cholesterol was not significantly depressed by the hypovitaminosis at any time during the study. Unlike the controls, mevalonate-2-C14 incorporation into serum cholesterol was significantly lowered in the 11-day-old pyridoxine-deficient chicks, but not at any other time during the study.The significance of these findings and the possible relationship between these factors are discussed.

Correlation between the Total Cholesterol Serum Concentration Data and Carbamazepine Steady-State Blood Levels in Humans

1983 ◽  
Vol 17 (11) ◽  
pp. 812-814 ◽  
Author(s):  
Leslaw M. Wichliński ◽  
Edmund Sieradzki ◽  
Maria Gruchala
Keyword(s):  
Steady State ◽  
Serum Cholesterol ◽  
Elevated Serum ◽  
Total Serum ◽  
Blood Levels ◽  
Gas Liquid Chromatography ◽  
Concentration Data ◽  
Cholesterol Levels ◽  
Multiple Doses ◽  
Elevated Serum Cholesterol

The purpose of this study was to investigate the pharmacokinetics of carbamazepine at steady state, after multiple doses in patients with elevated serum cholesterol levels. Twelve patients participated in the investigation; patients were divided into two groups according to their total serum cholesterol levels. Each patient received multiple doses of carbamazepine 600 mg po once per day. Blood samples were collected and analyzed for carbamazepine by gas-liquid chromatography. The clearance concept was used to describe the pharmacokinetic behavior of carbamazepine in high and low cholesterol patients. The area under the plasma concentration-time curve was determined by the trapezoidal rule method. This value was used to determine the oral dose clearance. In this study, the authors found that the elevated serum cholesterol and elevated total lipids cause a decrease in drug concentration. The significantly higher values of the total body clearance of carbamazepine, obtained in patients with elevated serum cholesterol levels, may have significance in clinical practice.

Elevated Serum Cholesterol Levels in Women with Premenstrual Dysphoric Disorder

2011 ◽  
Vol 42 (1) ◽  
pp. 85-92 ◽  
Author(s):  
Mei-Chun Hsiao ◽  
Chia-Yih Liu ◽  
Shi-Chieh Hsu ◽  
Cheng-Cheng Hsiao ◽  
Yi-Hsiung Lin ◽  
...  
Keyword(s):  
Serum Cholesterol ◽  
Elevated Serum ◽  
Premenstrual Dysphoric Disorder ◽  
Cholesterol Levels ◽  
Elevated Serum Cholesterol

To Test or Not to Test in Pediatric Practice?

1990 ◽  
Vol 12 (2) ◽  
pp. 35-38
Author(s):  
Lewis A. Barness
Keyword(s):  
Cardiovascular Disease ◽  
Serum Cholesterol ◽  
Elevated Level ◽  
Elevated Serum ◽  
Epidemiologic Studies ◽  
Present Knowledge ◽  
Pediatric Practice ◽  
Cholesterol Levels ◽  
Elevated Serum Cholesterol ◽  
Prevention Of Atherosclerosis

Decreasing atherosclerosis and atherosclerotic events is highly desirable, and the prevention of atherosclerosis and cardiovascular disease may be possible even from early ages. Attention has been focused by some on decreasing serum cholesterol levels. Serum cholesterol has been termed a "risk factor" for cardiovascular disease. This is a misnomer because, even in extensive epidemiologic studies in which elevated serum cholesterol levels have been associated with increased incidence of cardiovascular disease, no causal relationship has been established. A more accurate term, with present knowledge, is that an elevated level of serum cholesterol (or specific lipoprotein or apoproteins) is a "marker" for increased cardiovascular risk events.

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