scholarly journals Surgical Palliation Strategy Does Not Affect Interstage Ventricular Dysfunction or Atrioventricular Valve Regurgitation in Children With Hypoplastic Left Heart Syndrome and Variants

Circulation ◽  
2013 ◽  
Vol 128 (11_suppl_1) ◽  
pp. S205-S212 ◽  
Author(s):  
D. Chetan ◽  
Y. Kotani ◽  
F. Jacques ◽  
J. A. Poynter ◽  
L. N. Benson ◽  
...  
Keyword(s):  
Hypoplastic Left Heart Syndrome ◽  
Ventricular Dysfunction ◽  
Atrioventricular Valve ◽  
Left Heart ◽  
Valve Regurgitation ◽  
Hypoplastic Left Heart ◽  
Atrioventricular Valve Regurgitation ◽  
Surgical Palliation ◽  
Left Heart Syndrome

Risk-Stratified Approach to Hybrid Transcatheter–Surgical Palliation of Hypoplastic Left Heart Syndrome

2006 ◽  
Vol 27 (1) ◽  
pp. 91-95 ◽  
Author(s):  
D.S. Lim ◽  
B.B. Peeler ◽  
G.P. Matherne ◽  
I.L. Kron ◽  
H.P. Gutgesell
Keyword(s):  
Hypoplastic Left Heart Syndrome ◽  
Left Heart ◽  
Hypoplastic Left Heart ◽  
Surgical Palliation ◽  
Left Heart Syndrome

scholarly journals Novel Insights Into RV Adaptation and Function in Hypoplastic Left Heart Syndrome Between the First 2 Stages of Surgical Palliation

2011 ◽  
Vol 4 (2) ◽  
pp. 128-137 ◽  
Author(s):  
Nee Scze Khoo ◽  
Jeffrey F. Smallhorn ◽  
Sachie Kaneko ◽  
Kimberly Myers ◽  
Shelby Kutty ◽  
...  
Keyword(s):  
Hypoplastic Left Heart Syndrome ◽  
Left Heart ◽  
Hypoplastic Left Heart ◽  
Surgical Palliation ◽  
And Function ◽  
Left Heart Syndrome

Pathological changes and myocardial remodelling related to the mode of shunting following surgical palliation for hypoplastic left heart syndrome

2008 ◽  
Vol 18 (4) ◽  
pp. 415-422 ◽  
Author(s):  
Massimo A. Padalino ◽  
Chiara Castellani ◽  
Silvia Toffoli ◽  
Mila Della Barbera ◽  
Ornella Milanesi ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Right Ventricle ◽  
Hypoplastic Left Heart Syndrome ◽  
Pulmonary Arteries ◽  
Left Heart ◽  
Pulmonary Shunt ◽  
Hypoplastic Left Heart ◽  
Surgical Palliation ◽  
The Right ◽  
Left Heart Syndrome

AbstractBackgroundThe modification of placing the shunt from the right ventricle to the pulmonary arteries, also known as Sano procedure, has allegedly improved results over the short term in surgical palliation of hypoplastic left heart syndrome with the Norwood procedure. With this in mind, we reviewed autopsied specimens from neonates and children who did not survive after either a classic arterio-pulmonary shunt, or the modified procedure with the shunt placed from the right ventricle to the pulmonary arteries, so as to evaluate the pathological substrates of the remodelling of the systemic right ventricle, assessing any differences induced by the 2 techniques.MethodsWe obtained the hearts from 11 patients with neonatal diagnosis of hypoplastic left heart syndrome who died after the first or second stages of the Norwood sequence of operations, comparing them with 6 normal hearts matched for age and weight. Macroscopic, microscopic and morphometric analysis were performed on each specimen, evaluating the diameter of the myocytes, extracellular matrix remodelling in terms of fibrosis and type of collagen, and vascularization in terms of capillary density.ResultsHypertrophy of the myocytes was significantly increased in the hearts from patients having either a classic arterio-pulmonary or the ventriculo-pulmonary modification of the shunt compared to controls (p < 0.05). Myocardial fibrosis was increased in those having a shunt placed from the right ventricle to the pulmonary arteries when compared to the other 2 groups. The ratio of collagen I to collagen III was similar in those undergoing a classic arterio-pulmonary shunt compared to controls (0.94), but was lower in those having a shunt placed from the right ventricle to the pulmonary arteries (0.61), with an increase in collagen type III. The density of capillaries was lower in those who had undergone a classic arterial shunt when compared to the others.ConclusionWe have shown greater remodelling of the ventricular myocardial extracellular matrix in patients having a shunt from the right ventricle to the pulmonary arteries when compared to those having a classic arterio-pulmonary shunt, with this remodelling progressing even after the neonatal period. This may influence a later suboptimal ventricular performance.

Outcomes in Patients with Persistent Ventricular Dysfunction After Stage I Palliation for Hypoplastic Left Heart Syndrome

2015 ◽  
Vol 37 (2) ◽  
pp. 239-247 ◽  
Author(s):  
Emilie Jean-St-Michel ◽  
Devin Chetan ◽  
Steven M. Schwartz ◽  
Glen S. Van Arsdell ◽  
Alejandro A. Floh ◽  
...  
Keyword(s):  
Hypoplastic Left Heart Syndrome ◽  
Ventricular Dysfunction ◽  
Stage I ◽  
Left Heart ◽  
Hypoplastic Left Heart ◽  
Left Heart Syndrome

scholarly journals Surgical palliation for an infant with hypoplastic left heart syndrome and congenital lobar emphysema: a case report

2021 ◽  
Vol 3 (1) ◽  
pp. 01-04
Author(s):  
Raj Sahulee
Keyword(s):  
Congenital Heart Disease ◽  
Hypoplastic Left Heart Syndrome ◽  
Congenital Heart ◽  
Left Heart ◽  
Hypoplastic Left Heart ◽  
Congenital Lobar Emphysema ◽  
First Case ◽  
Surgical Palliation ◽  
Lobar Emphysema ◽  
Left Heart Syndrome

Hypoplastic left heart syndrome is a form of congenital heart disease that is associated with significant lifelong morbidity and mortality. Although rarely reported together, the prognosis for patients with hypoplastic left heart syndrome and congenital anomalies of the airway or lung, such as congenital diaphragmatic hernia, has been shown to be very poor. The outcomes for patients with hypoplastic left heart syndrome and congenital lobar emphysema specifically is currently unknown. Reported herein is the first case of a child with a rare combination of hypoplastic left heart syndrome and congenital lobar emphysema, and a discussion of his presentation, diagnosis, management and outcome to date.

scholarly journals Hybrid procedure as an alternative to surgical palliation of high-risk infants with hypoplastic left heart syndrome and its variants

2010 ◽  
Vol 139 (5) ◽  
pp. 1211-1215 ◽  
Author(s):  
Prem S. Venugopal ◽  
Karyn P. Luna ◽  
David R. Anderson ◽  
Conal B. Austin ◽  
Eric Rosenthal ◽  
...  
Keyword(s):  
High Risk ◽  
Hypoplastic Left Heart Syndrome ◽  
Hybrid Procedure ◽  
Left Heart ◽  
Hypoplastic Left Heart ◽  
Surgical Palliation ◽  
High Risk Infants ◽  
Left Heart Syndrome
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