scholarly journals Randomized, Double-Blind, Placebo-Controlled Study on Effects of Raloxifene and Hormone Replacement Therapy on Plasma NO Concentrations, Endothelin-1 Levels, and Endothelium-Dependent Vasodilation in Postmenopausal Women

2001 ◽  
Vol 21 (9) ◽  
pp. 1512-1519 ◽  
Author(s):  
Antonino Saitta ◽  
Domenica Altavilla ◽  
Domenico Cucinotta ◽  
Nunziata Morabito ◽  
Nicola Frisina ◽  
...  
Keyword(s):  
Hormone Replacement Therapy ◽  
Replacement Therapy ◽  
Postmenopausal Women ◽  
Hormone Replacement ◽  
Controlled Study ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Endothelin 1

scholarly journals Hormone Replacement Therapy in Women with Epilepsy: A Randomized, Double-Blind, Placebo-Controlled Study

Epilepsia ◽  
2006 ◽  
Vol 47 (9) ◽  
pp. 1447-1451 ◽  
Author(s):  
Cynthia L. Harden ◽  
Andrew G. Herzog ◽  
Blagovest G. Nikolov ◽  
Barbara S. Koppel ◽  
Paul J. Christos ◽  
...  
Keyword(s):  
Hormone Replacement Therapy ◽  
Replacement Therapy ◽  
Hormone Replacement ◽  
Controlled Study ◽  
Double Blind ◽  
Double Blind Placebo

scholarly journals Effects of hormone replacement therapy in rheumatoid arthritis: a double blind placebo-controlled study.

1994 ◽  
Vol 53 (1) ◽  
pp. 54-57 ◽  
Author(s):  
A G MacDonald ◽  
E A Murphy ◽  
H A Capell ◽  
U Z Bankowska ◽  
S H Ralston
Keyword(s):  
Rheumatoid Arthritis ◽  
Hormone Replacement Therapy ◽  
Replacement Therapy ◽  
Hormone Replacement ◽  
Controlled Study ◽  
Double Blind ◽  
Double Blind Placebo

Efficacy and tolerability of continuous combined hormone replacement therapy in early postmenopausal women

2007 ◽  
Vol 13 (3) ◽  
pp. 124-131 ◽  
Author(s):  
L A Mattsson ◽  
S Skouby ◽  
M Rees ◽  
J Heikkinen ◽  
M Kudela ◽  
...  
Keyword(s):  
Hormone Replacement Therapy ◽  
Replacement Therapy ◽  
Postmenopausal Women ◽  
Dose Regimen ◽  
Hormone Replacement ◽  
Secondary Outcome ◽  
Estradiol Valerate ◽  
Hot Flushes ◽  
Double Blind ◽  
Early Postmenopausal Women

Objective. Continuous combined hormone replacement therapy (ccHRT) based on estradiol valerate (E2V) and medroxyprogesterone acetate (MPA) is effective for relief of menopausal symptoms three years or more after the menopause. This study was undertaken to examine the efficacy and tolerability of ccHRT in early postmenopausal women (last menstrual period 1.3 years before study entry). Study design. This was a 52-week, randomized, double-blind, multinational study of ccHRT comprising three different dose combinations of E2V/MPA in 459 early postmenopausal non-hysterectomized women experiencing 30 or more moderate to severe hot flushes a week and/or vasomotor symptoms requiring treatment. Main outcomes measures. The primary endpoint was change in frequency and severity of moderate to severe hot flushes at 12 weeks. Secondary outcome measures included number of bleeding days and evaluation of tolerability. Results. The frequency of hot flushes was reduced by ≥70% after one month ( P<0.001 for all doses at week 2 onwards), with little evidence of statistically different dose effects. Severity of flushing was also attenuated by ccHRT. Mean number of bleeding days fell to <1 per 28-day cycle at 52 weeks. Rates of amenorrhoea approached 80–90% at the end of the study, but were significantly lower at several time points with the highest-dose regimen (2 mg E2V + 5 mg MPA) than with the lower-dose options (1 mg E2V + 2.5 mg MPA and 1 mg E2V + 5 mg MPA; P<0.05). Adverse events declined in frequency over time with all regimens but throughout the study were more numerous with the highest-dose regimen than with lower doses ( P= 0.0002). Conclusions. Continuous combined HRT was effective for the relief of climacteric symptoms in early postmenopausal women and was well tolerated.

Sign in / Sign up

Export Citation Format

Share Document