A new species ofCirolanaLeach, 1818, collected from Cenote Aerolito, Cozumel Island, Mexican Caribbean, is described.Cirolana(Anopsilana)adrianisp. nov. has a body 2.7× as long as wide, widest at pereonites 5-6; cephalon smooth, with small rostral point; pereonites without tubercles or ridges; antenna 2 not surpassing back of segment 2 of pereon; pleonite 4 lacking free ventrolateral margins; pleotelson as long as wide, smooth, with 9 distal robust setae; appendix masculina extremely long, 2× as long as endopod of pleopod 2. The main differences between the new species and the marine speciesCirolana(Anopsilana)jonesi(Kensley, 1987) andC.(A.)sinu(Kensley & Schotte, 1994), as well as the stygobitic speciesC.(A.)yucatanaBotosaneanu & Iliffe, 2000, the most similar known species ofCirolana(Anopsilana) in the region, are described. This is the second isopod of the genusCirolanarecorded from the karstic systems of the Yucatan Peninsula.