P190RhoGAP Mediates Protective Effects Of Oxidized Phospholipids In The Models Of Ventilator Induced Lung Injury

2011 ◽  
Author(s):  
Oleksii Dubrovskyi ◽  
Noureddine Zebda ◽  
Panfeng Fu ◽  
Ivan Cokic ◽  
Anna Birukova ◽  
...  
Keyword(s):  
Lung Injury ◽  
Protective Effects ◽  
Oxidized Phospholipids ◽  
Ventilator Induced Lung Injury

Protective effects of oxidized phospholipids on ventilator-induced lung injury

2006 ◽  
Vol 39 ◽  
pp. S601
Author(s):  
A.A. Birukova ◽  
S.A. Nonas ◽  
I. Miller ◽  
S. Chatchavalvanich ◽  
J.G.N. Garcia ◽  
...  
Keyword(s):  
Lung Injury ◽  
Protective Effects ◽  
Oxidized Phospholipids ◽  
Ventilator Induced Lung Injury

15 PROTECTIVE EFFECTS OF OXIDIZED PHOSPHOLIPIDS ON VENTILATOR-INDUCED LUNG INJURY.

2006 ◽  
Vol 54 (2) ◽  
pp. S346.2-S346
Author(s):  
D. O. Burdette ◽  
S. A. Nonas ◽  
I. Miller ◽  
A. A. Birukova ◽  
S. Chatchavalvanich ◽  
...  
Keyword(s):  
Lung Injury ◽  
Protective Effects ◽  
Oxidized Phospholipids ◽  
Ventilator Induced Lung Injury

OXIDIZED PHOSPHOLIPIDS EXHIBIT PROTECTIVE EFFECTS IN THE MODELS OF VENTILATOR-INDUCED LUNG INJURY

2008 ◽  
Vol 41 ◽  
pp. S397
Author(s):  
Anna A. Birukova ◽  
Panfeng Fu ◽  
Jungjie Xing ◽  
Santipongse Chatchavalvanich ◽  
Konstantin G. Birukov
Keyword(s):  
Lung Injury ◽  
Protective Effects ◽  
Oxidized Phospholipids ◽  
Ventilator Induced Lung Injury

scholarly journals p190RhoGAP mediates protective effects of oxidized phospholipids in the models of ventilator-induced lung injury☆

2011 ◽  
Vol 317 (6) ◽  
pp. 859-872 ◽  
Author(s):  
Anna A. Birukova ◽  
Noureddine Zebda ◽  
Ivan Cokic ◽  
Panfeng Fu ◽  
Tinghuai Wu ◽  
...  
Keyword(s):  
Lung Injury ◽  
Protective Effects ◽  
Oxidized Phospholipids ◽  
Ventilator Induced Lung Injury

Protective effects of hemin in an experimental model of ventilator-induced lung injury

2011 ◽  
Vol 661 (1-3) ◽  
pp. 102-108 ◽  
Author(s):  
Li An ◽  
Chang-Ting Liu ◽  
Xue-Bing Qin ◽  
Qing-Hui Liu ◽  
Yan Liu ◽  
...  
Keyword(s):  
Lung Injury ◽  
Experimental Model ◽  
Protective Effects ◽  
Ventilator Induced Lung Injury

scholarly journals Protective effects of adenosine A2A receptor agonist in ventilator-induced lung injury in rats

2009 ◽  
Vol 37 (7) ◽  
pp. 2235-2241 ◽  
Author(s):  
Chin-Ming Chen ◽  
Oscar Penuelas ◽  
Kieran Quinn ◽  
Kuo-Chen Cheng ◽  
Chien-Feng Li ◽  
...  
Keyword(s):  
Lung Injury ◽  
Receptor Agonist ◽  
Adenosine A2a Receptor ◽  
Protective Effects ◽  
Ventilator Induced Lung Injury ◽  
A2a Receptor ◽  
Adenosine A2a

scholarly journals Rap1 mediates protective effects of iloprost against ventilator-induced lung injury

2009 ◽  
Vol 107 (6) ◽  
pp. 1900-1910 ◽  
Author(s):  
Anna A. Birukova ◽  
Panfeng Fu ◽  
Junjie Xing ◽  
Konstantin G. Birukov
Keyword(s):  
Lung Injury ◽  
Bronchoalveolar Lavage ◽  
Tidal Volume ◽  
Evans Blue ◽  
High Tidal Volume ◽  
Protective Effects ◽  
Ventilator Induced Lung Injury ◽  
High Tidal Volume Ventilation ◽  
Volume Ventilation

Prostaglandin I2 (PGI2) has been shown to attenuate vascular constriction, hyperpermeability, inflammation, and acute lung injury. However, molecular mechanisms of PGI2 protective effects on pulmonary endothelial cells (EC) are not well understood. We tested a role of cAMP-activated Epac-Rap1 pathway in the barrier protective effects of PGI2 analog iloprost in the murine model of ventilator-induced lung injury. Mice were treated with iloprost (2 μg/kg) after onset of high tidal volume ventilation (30 ml/kg, 4 h). Bronchoalveolar lavage, histological analysis, and measurements of Evans blue accumulation were performed. In vitro, microvascular EC barrier function was assessed by morphological analysis of agonist-induced gap formation and monitoring of Rho pathway activation and EC permeability. Iloprost reduced bronchoalveolar lavage protein content, neutrophil accumulation, capillary filtration coefficient, and Evans blue albumin extravasation caused by high tidal volume ventilation. Small-interfering RNA-based Rap1 knockdown inhibited protective effects of iloprost. In vitro, iloprost increased barrier properties of lung microvascular endothelium and alleviated thrombin-induced EC barrier disruption. In line with in vivo results, Rap1 depletion attenuated protective effects of iloprost in the thrombin model of EC permeability. These data describe for the first time protective effects for Rap1-dependent signaling against ventilator-induced lung injury and pulmonary endothelial barrier dysfunction.

Protective Effects of Dexmedetomidine-Ketamine Combination Against Ventilator-Induced Lung Injury in Endotoxemia Rats

2011 ◽  
Vol 167 (2) ◽  
pp. e273-e281 ◽  
Author(s):  
Chih-Lin Yang ◽  
Cay-Huyen Chen ◽  
Pei-Shan Tsai ◽  
Tao-Yeuan Wang ◽  
Chun-Jen Huang
Keyword(s):  
Lung Injury ◽  
Protective Effects ◽  
Ventilator Induced Lung Injury

Protective Effects of Hypercapnic Acidosis on Ventilator-induced Lung Injury

2001 ◽  
Vol 164 (5) ◽  
pp. 802-806 ◽  
Author(s):  
ALAIN F. BROCCARD ◽  
JOHN R. HOTCHKISS ◽  
CHRISTINE VANNAY ◽  
MICHELE MARKERT ◽  
ALAIN SAUTY ◽  
...  
Keyword(s):  
Lung Injury ◽  
Protective Effects ◽  
Hypercapnic Acidosis ◽  
Ventilator Induced Lung Injury

Protective effects of ghrelin in ventilator-induced lung injury in rats

2017 ◽  
Vol 52 ◽  
pp. 85-91 ◽  
Author(s):  
Guang Li ◽  
Jiao Liu ◽  
Wen-Fang Xia ◽  
Chen-Liang Zhou ◽  
Li-Qiong Lv
Keyword(s):  
Lung Injury ◽  
Protective Effects ◽  
Ventilator Induced Lung Injury
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