scholarly journals Catastrophic Non-Cardiogenic Pulmonary Edema Secondary to Massive Verapamil Overdose and Treatment with Extracorporeal Membrane Oxygenation

Author(s):  
A.T.N. Ho ◽  
T.N. Pham ◽  
C.R. Barrios
1988 ◽  
Vol 69 (4) ◽  
pp. 609-613 ◽  
Author(s):  
M. A. Pilato ◽  
N. W. Fleming ◽  
N. M. Katz ◽  
J. J. O'connell ◽  
M. W. Krucoff ◽  
...  

2020 ◽  
Vol 2020 ◽  
pp. 1-3
Author(s):  
An Ho ◽  
Abigail Go ◽  
Christopher Barrios ◽  
Anthony Scalzo

Calcium channel blocker (CCB) poisoning frequently presents with cardiovascular complications such as cardiogenic shock and arrhythmia. We present a case of massive verapamil overdose causing refractory noncardiogenic pulmonary edema successfully treated with extracorporeal membrane oxygenation. To our knowledge, this is the first case with these features reported in literature. A 27-year-old female patient presented with an overdose of 18,000 mg of verapamil. Her clinical condition deteriorated to severe hypoxic respiratory failure despite being treated with calcium, high-dose insulin, and full invasive ventilation support. She eventually required venovenous extracorporeal membrane oxygenation (VV-ECMO) for three days with full recovery. Large ingestion of verapamil could lead to noncardiogenic pulmonary edema. VV-ECMO might play an important role to support the treatment in severe cases with refractory hypoxia.


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