scholarly journals Parkinson’s Disease Treatment Using Cell Transplantation

2020 ◽  
Vol 5 (3) ◽  
pp. 24
Author(s):  
Sana Khalid
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cell Transplantation ◽  
Disease Treatment

scholarly journals Gut microbiota mediates the absorption of FLZ, a new drug for Parkinson’s disease treatment

2021 ◽  
Author(s):  
Junmei Shang ◽  
Shurong Ma ◽  
Caixia Zang ◽  
Xiuqi Bao ◽  
Yan Wang ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Gut Microbiota ◽  
Disease Treatment ◽  
New Drug

scholarly journals Discovery and characterization of naturally occurring potent inhibitors of catechol-O-methyltransferase from herbal medicines

RSC Advances ◽  
2021 ◽  
Vol 11 (17) ◽  
pp. 10385-10392
Author(s):  
Dong-Fang Zhao ◽  
Yu-Fan Fan ◽  
Fang-Yuan Wang ◽  
Fan-Bin Hou ◽  
Frank J. Gonzalez ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Herbal Medicines ◽  
Disease Treatment ◽  
Naturally Occurring

Discovery and characterization of natural human catechol-O-methyltransferase (hCOMT) inhibitors for Parkinson's disease treatment.

scholarly journals Foetal Cell Transplantation for Parkinson’s Disease: Focus on Graft-Induced Dyskinesia

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Elisabetta Tronci ◽  
Camino Fidalgo ◽  
Manolo Carta
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cell Transplantation ◽  
Open Label ◽  
Double Blind ◽  
Clinical Investigations ◽  
Serotonin Neurons ◽  
Ventral Mesencephalic ◽  
Preclinical And Clinical Studies ◽  
Foetal Cell

Transplantation of dopamine- (DA-) rich foetal ventral mesencephalic cells emerged as a promising therapy for Parkinson’s disease (PD), as it allowed significant improvement of motor symptoms in several PD patients in open-label studies. However, double-blind clinical trials have been largely disappointing. The general agreement in the field is that the lack of standardization of tissue collection and preparation, together with the absence of postsurgical immunosuppression, played a key role in the failure of these studies. Moreover, a further complication that emerged in previous studies is the appearance of the so-called graft-induced dyskinesia (GID), in a subset of grafted patients, which resembles dyskinesia induced by L-DOPA but in the absence of medication. Preclinical evidence pointed to the serotonin neurons as possible players in the appearance of GID. In agreement, clinical investigations have shown that grafted tissue may contain a large number of serotonin neurons, in the order of half of the DA cells; moreover, the serotonin 5-HT1A receptor agonist buspirone has been found to produce significant dampening of GID in grafted patients. In this paper, we will review the recent preclinical and clinical studies focusing on cell transplantation for PD and on the mechanisms underlying GID.

Cell Transplantation and Gene Therapy in Parkinson's Disease

2011 ◽  
Vol 78 (1) ◽  
pp. 126-158 ◽  
Author(s):  
Dustin R. Wakeman ◽  
Hemraj B. Dodiya ◽  
Jeffrey H. Kordower
Keyword(s):  
Parkinson’S Disease ◽  
Gene Therapy ◽  
Parkinson's Disease ◽  
Cell Transplantation

Gold nanoclusters for Parkinson's disease treatment

Biomaterials ◽  
2019 ◽  
Vol 194 ◽  
pp. 36-46 ◽  
Author(s):  
Guanbin Gao ◽  
Rui Chen ◽  
Meng He ◽  
Jing Li ◽  
Jing Li ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Gold Nanoclusters ◽  
Disease Treatment
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