Bone Mesenchymal Stem Cells (BMSCs) Transplantation Can Repair Rat Femoral Head Necrosis and Inhibit the Expression of Omgp

To study the therapeutic effect of BMSCs on femoral head necrosis and whether it can inhibit the growth of OMgP. 15 healthy rats were divided into ZZ group (normal group), GT group (femoral head necrosis) and MM group (BMSCs transplantation). At 1 h, 3 h, 1 d, and 3 d, the expression of OMgP in GT group were higher than ZZ group (P <0.05) and MM group, indicating that BMSCs transplantation can decreased OMgP expression. At 1 d, 7 d, and 14 d, BBB scores of the GT group were lower than ZZ group (P < 0.05) and MM group (P < 0.05), indicating that BMSCs transplantation can improve spinal cord injury behavior. The cells in ZZ group were well stained and morphologically intact, the femoral head was not damaged, and the articular surface was smooth, GT group had cartilage necrosis with disordered inferior epiphysis, and the femoral head of the MM group had less damage and increased osteoblasts. The blood vessel counts in necrotic area in GT group were higher than ZZ group and MM group with decreased new bone area in repair area compared to ZZ and MM group (P <0.05), indicating that the area of femoral head necrosis after BMSCs transplantation was improved. The levels of ALP and BGP in GT group were lower than ZZ group (P <0.05) and MM group (P <0.05). Bone marrow mesenchymal stem cell transplantation can effectively repair new bone area, up-regulate ALP and BGP, and have a positive effect on femoral head necrosis, possibly by inhibiting OMGP activity.