Expression and Modulation of RPE Cell Membrane Complement Regulatory Proteins

2009 ◽  
Vol 50 (7) ◽  
pp. 3473 ◽  
Author(s):  
Ping Yang ◽  
Jillian Tyrrell ◽  
Ian Han ◽  
Glenn J. Jaffe
Keyword(s):  
Cell Membrane ◽  
Regulatory Proteins ◽  
Complement Regulatory Proteins

scholarly journals Release of C8 binding protein (C8bp) from the cell membrane by phosphatidylinositol-specific phospholipase C

Blood ◽  
1988 ◽  
Vol 72 (3) ◽  
pp. 1089-1092
Author(s):  
GM Hansch ◽  
PF Weller ◽  
A Nicholson-Weller
Keyword(s):  
Plasma Membrane ◽  
Cell Membrane ◽  
Phospholipase C ◽  
Paroxysmal Nocturnal Hemoglobinuria ◽  
Binding Protein ◽  
Regulatory Proteins ◽  
Membrane Expression ◽  
Normal Cells ◽  
Complement Regulatory Proteins ◽  
Common Defect

Abstract Erythrocytes from patients with paroxysmal nocturnal hemoglobinuria (PNH) are abnormally sensitive to complement. Two membrane proteins, the C8 binding protein (C8bp) and the decay accelerating factor (DAF), which are expressed on normal cells, function to restrict lysis by homologous complement, and both of these proteins are absent from PNH erythrocytes. DAF is anchored to the plasma membrane on normal cells by a phosphatidylinositol linkage. The investigators found that a purified phosphatidylinositol-specific phospholipase C cleaved C8bp from the surface of normal lymphocytes and monocytes. This finding indicates that the abnormal complement sensitivity of PNH erythrocytes arises from a common defect, the inability to attach the phosphatidylinositol- containing anchor that is necessary for the membrane expression of both membrane complement regulatory proteins, the C8bp, and DAF.

scholarly journals Release of C8 binding protein (C8bp) from the cell membrane by phosphatidylinositol-specific phospholipase C

Blood ◽  
1988 ◽  
Vol 72 (3) ◽  
pp. 1089-1092 ◽  
Author(s):  
GM Hansch ◽  
PF Weller ◽  
A Nicholson-Weller
Keyword(s):  
Plasma Membrane ◽  
Cell Membrane ◽  
Phospholipase C ◽  
Paroxysmal Nocturnal Hemoglobinuria ◽  
Binding Protein ◽  
Regulatory Proteins ◽  
Membrane Expression ◽  
Normal Cells ◽  
Complement Regulatory Proteins ◽  
Common Defect

Erythrocytes from patients with paroxysmal nocturnal hemoglobinuria (PNH) are abnormally sensitive to complement. Two membrane proteins, the C8 binding protein (C8bp) and the decay accelerating factor (DAF), which are expressed on normal cells, function to restrict lysis by homologous complement, and both of these proteins are absent from PNH erythrocytes. DAF is anchored to the plasma membrane on normal cells by a phosphatidylinositol linkage. The investigators found that a purified phosphatidylinositol-specific phospholipase C cleaved C8bp from the surface of normal lymphocytes and monocytes. This finding indicates that the abnormal complement sensitivity of PNH erythrocytes arises from a common defect, the inability to attach the phosphatidylinositol- containing anchor that is necessary for the membrane expression of both membrane complement regulatory proteins, the C8bp, and DAF.

The expression of membrane-bound complement regulatory proteins CD46, CD55 and CD59 in oral lichen planus

2021 ◽  
Vol 124 ◽  
pp. 105064
Author(s):  
Lulu Li ◽  
Beibei Cong ◽  
Xixi Yu ◽  
Songsong Deng ◽  
Mengjia Liu ◽  
...  
Keyword(s):  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Regulatory Proteins ◽  
Complement Regulatory Proteins ◽  
Membrane Bound ◽  
Oral Lichen

Application of Protein A-Rosette Assay for Screening of Monoclonal Antibodies to Human Complement Regulatory Proteins

1990 ◽  
Vol 7 (2) ◽  
pp. 78-89 ◽  
Author(s):  
Tsukasa Seya ◽  
Tomoko Hara ◽  
Akiko Uenaka ◽  
Eiichi Nakayama ◽  
Hitoshi Akedo
Keyword(s):  
Monoclonal Antibodies ◽  
Protein A ◽  
Regulatory Proteins ◽  
Human Complement ◽  
Complement Regulatory Proteins

X-Irradiation Does Not Affect the Levels of Complement Regulatory Proteins, CD35 (CR1), CD55 (DAF) and CD59 on Concentrated Red Cells

Vox Sanguinis ◽  
1996 ◽  
Vol 71 (4) ◽  
pp. 243-244
Author(s):  
Yasuo Fukumori ◽  
Tsukasa Seya ◽  
Shiro Ohnoki ◽  
Hirotoshi Shibata ◽  
Hideo Yamaguchi
Keyword(s):  
Red Cells ◽  
Regulatory Proteins ◽  
Complement Regulatory Proteins ◽  
X Irradiation

Role of complement regulatory proteins CD46, CD55 and CD59 in reproduction

2012 ◽  
Vol 61 (1) ◽  
pp. 84-94 ◽  
Author(s):  
Michaela Frolíková ◽  
Romana Stopková ◽  
Jana Antalíková ◽  
Peter M. Johnson ◽  
Pavel Stopka ◽  
...  
Keyword(s):  
Regulatory Proteins ◽  
Complement Regulatory Proteins

scholarly journals Binding of complement regulatory proteins to Group A Streptococcus

Vaccine ◽  
2008 ◽  
Vol 26 ◽  
pp. I75-I78 ◽  
Author(s):  
Maria A. Oliver ◽  
José M. Rojo ◽  
Santiago Rodríguez de Córdoba ◽  
Sebastián Alberti
Keyword(s):  
Group A Streptococcus ◽  
Regulatory Proteins ◽  
Complement Regulatory Proteins ◽  
Group A
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