Comparing Corneal Variables in Healthy Subjects and Patients with Primary Open-Angle Glaucoma

2011 ◽  
Vol 52 (6) ◽  
pp. 3683 ◽  
Author(s):  
Federico Saenz-Frances ◽  
Julian Garcia-Feijó ◽  
Luis Jañez ◽  
Lara Borrego-Sanz ◽  
Jose M. Martinez de la Casa ◽  
...  
Keyword(s):  
Healthy Subjects ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Open Angle

scholarly journals Diagnostic capability of different morphological parameters for primary open‐angle glaucoma in the Chinese population

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Ruoshi Li ◽  
Xia Wang ◽  
Yahui Wei ◽  
Yuan Fang ◽  
Tian Tian ◽  
...  
Keyword(s):  
Healthy Subjects ◽  
Chinese Population ◽  
Primary Open Angle Glaucoma ◽  
Early Stage ◽  
Open Angle Glaucoma ◽  
Structural Parameters ◽  
Open Angle ◽  
Fiber Layer ◽  
Diagnostic Capability ◽  
Diagnostic Power

Abstract Background To assess the diagnostic capability of novel Bruch’s membrane opening (BMO)-based disc parameters, the BMO-minimum rim width (BMO-MRW) and the BMO-minimum rim area (BMO-MRA) in the Chinese population and compare them to the retinal nerve fiber layer (RNFL) from optical coherence tomography (OCT) and the rim area (RA) from the Heidelberg retinal tomograph-III (HRT-III). Methods In total, 200 eyes of 77 healthy and 123 primary open-angle glaucoma (POAG) subjects were included in this cross-sectional study. All participants underwent the visual field test and structural measurements by OCT and HRT-III. The areas under the receiver operating characteristic curves (AUCs) of different structural parameters were calculated to assess their diagnostic power and compared using the DeLong test. Results In populations with different characteristics, the BMO-MRW and BMO-MRA had better diagnostic power than the RA. In discriminating between all POAG subjects and healthy controls and between early-stage patients and controls, the global BMO-MRW had comparable AUCs with the RNFL, but the BMO-MRA had lower AUCs than the RNFL. In healthy subjects with macrodiscs, both the global and sectoral BMO-MRW were thinner than those in healthy subjects with normal disc size. The AUCs of BMO-MRA, BMO-MRW and RNFL in subjects with macrodiscs were comparable. Additionally, in the myopic population, the BMO-MRA and BMO-MRW had comparable AUCs with the RNFL. Conclusions The BMO-MRW had comparable diagnostic power with the RNFL, and compared with BMO-MRW, the BMO-MRA might have advantages in certain populations, such as macrodiscs. All OCT-derived parameters exceeded the RA in diagnostic capability.

scholarly journals Informative value of biometric indices of iris, clear and cornea in primary open-angle glaucoma diagnosis

2018 ◽  
Vol 11 (1) ◽  
pp. 34-40
Author(s):  
Vladimir V Strakhov ◽  
Victor V Alekseev ◽  
Abdulgavi M Al-Mrrani ◽  
Anastasiya A Popova ◽  
Olga N Klimova
Keyword(s):  
Healthy Subjects ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Control Group ◽  
Open Angle ◽  
Tissue Thickness ◽  
Glaucoma Diagnosis ◽  
Primary Glaucoma ◽  
Positive Direct ◽  
Biometric Indices

Aim: to study the thickness of cornea, iris and scleral tissue, to determine its asymmetry between fellow eyes in healthy subjects and in patients with primary glaucoma. To determine the relationship between changes in biomechanical properties of the cornea and sclera and iris thickness in healthy subjects and in patients with primary glaucoma. Materials and methods. 10 patients (20 eyes) with primary glaucoma were examined. The control group consisted of 10 people (20 eyes). In all patients ultrasound biomicroscopy (Humphrey Instruments (USA), Model 840) was performed. Results and discussion. The article presents a study of the corneoscleral and iris tissue thickness in primary glaucoma, as well as the increase pattern of the revealed asymmetry in corneoscleral and iris tissue thickness from normal state to glaucoma. A positive direct correlation between the indices of cornea, sclera, and iris thickness in the primary glaucoma group and between biometric parameters of sclera and iris and the of corneal hysteresis value in primary open-angle glaucoma. (For citation: Strakhov VV, Alekseev VV, Al'-Mrrani AM, et al. Informative value of biometric indices of iris, clear and cornea in primary open-angle glaucoma diagnosis. Ophthalmology Journal. 2018;11(1):34-40. doi: 10.17816/OV11134-40).

Diurnal fluctuations of macular vessel density in patients with primary open-angle glaucoma and healthy subjects

2020 ◽  
Vol 40 (9) ◽  
pp. 2257-2266
Author(s):  
Xiaojie Wang ◽  
Juanjuan Chen ◽  
Shaodan Zhang ◽  
Xiao Shang ◽  
Kun Zhou ◽  
...  
Keyword(s):  
Healthy Subjects ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Vessel Density ◽  
Open Angle ◽  
Diurnal Fluctuations

scholarly journals Anterior Lamina Cribrosa Insertion in Primary Open-Angle Glaucoma Patients and Healthy Subjects

PLoS ONE ◽  
2014 ◽  
Vol 9 (12) ◽  
pp. e114935 ◽  
Author(s):  
Kyoung Min Lee ◽  
Tae-Woo Kim ◽  
Robert N. Weinreb ◽  
Eun Ji Lee ◽  
Michaël J. A. Girard ◽  
...  
Keyword(s):  
Healthy Subjects ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Lamina Cribrosa ◽  
Open Angle

scholarly journals Native fluorescence of tear fluid as a tool for diagnostics of glaucoma

RSC Advances ◽  
2021 ◽  
Vol 11 (18) ◽  
pp. 10842-10846
Author(s):  
Kristína Krajčíková ◽  
Miriama Skirková ◽  
Monika Moravská ◽  
Anna Birková ◽  
Vladimíra Tomečková
Keyword(s):  
Ocular Hypertension ◽  
Healthy Subjects ◽  
Screening Tool ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Tear Fluid ◽  
Open Angle ◽  
Native Fluorescence

Tear fluid native fluorescence differs among patients with primary open-angle glaucoma, suspected glaucoma, ocular hypertension, and healthy subjects and could serve as a diagnostic or screening tool in future.

scholarly journals Anterior Segment Optical Coherence Tomography Analysis of Iris Morphometric Changes Induced by Prostaglandin Analogues Treatment in Patients with Primary Open Angle Glaucoma or Ocular Hypertension

2018 ◽  
Vol 12 (1) ◽  
pp. 110-120
Author(s):  
R Mancino ◽  
E Di Carlo ◽  
D Napoli ◽  
A Martucci ◽  
A Mauro ◽  
...  
Keyword(s):  
Ocular Hypertension ◽  
Healthy Subjects ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Thickness Reduction ◽  
Secondary Outcome ◽  
Open Angle ◽  
Treatment Length ◽  
Prostaglandin Analogues ◽  
Muscle Region

Background: The study aimed to evaluate iris thickness changes in patients with Primary Open Angle Glaucoma (POAG) or Ocular Hypertension (OHT) under treatment with Prostaglandin Analogues (PG). Objectives: Primary outcome measures were iris thickness at the region of Dilator Muscle Region (DMR) and Sphincter Muscle Region (SMR). DMR/SMR ratio was also evaluated. The secondary outcome was the correlation between PG treatment length and iris parameters. Methods: The charts of patients with POAG or OHT who underwent Visante OCT were retrospectively selected. The patients were divided in a group using PG for at least 6 months and a group using hypotensive drops not including PG or alpha-adrenergic agonists. A third group included healthy subjects. Result: 98 subjects were selected. Patients with POAG or OHT using PG eyedrops showed a significant iris thickness reduction at DMR compared to healthy subjects and to patients using hypotensive eyedrops not containing PG. Significantly higher SMR thickness values were found in PG group compared to both control groups. DMR/SMR ratio significantly reduced in PG group. No correlation was found between PG treatment length and iris parameters. Conclusion: The present data indicate that PG treatment induced DMR thickness reduction and an increase in SMR thickness. These changes were not related to the duration of PG exposure.

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